Muscle Cell News Volume 6.15 | Apr 26 2021

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    2021-04-26 | MUSCN 6.15


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.15 – 26 April, 2021
    TOP STORY

    VPS39-Deficiency Observed in Type 2 Diabetes Impairs Muscle Stem Cell Differentiation via Altered Autophagy and Epigenetics

    Scientists discovered a pathway connecting VPS39-deficiency in human myoblasts to impaired autophagy, abnormal epigenetic reprogramming, dysregulation of myogenic regulators, and perturbed differentiation.
    [Nature Communications]

    Full Article

    Derive and expand human skeletal muscle progenitors in a serum-free setting using MyoCult™-SF Expansion Supplement Kit (Human).
    PUBLICATIONSRanked by the impact factor of the journal

    Assessment of Arrhythmia Mechanism and Burden of the Infarcted Ventricles Following Remuscularization with Pluripotent Stem Cell-Derived Cardiomyocyte Patches Using Patient-Derived Models

    Researchers investigated two possible mechanisms of arrhythmogenesis—focal vs reentrant—arising from direct remuscularization with pluripotent stem cell-derived cardiomyocyte patches in two personalized, human ventricular computer models of post-myocardial infarction.
    [Cardiovascular Research]

    AbstractGraphical Abstract

    Overexpression of circRNA SNRK Targets miR-103-3p to Reduce Apoptosis and Promote Cardiac Repair Through GSK3β/β-Catenin Pathway in Rats with Myocardial Infarction

    circRNA regulated cardiomyocyte apoptosis and proliferation by acting as a miR-103-3p sponge and inducing increased expression of SNRK which could bind GSK3β to regulate its phosphorylated activity.
    [Cell Death Discovery]

    Full Article

    GLUT1 Overexpression Enhances Glucose Metabolism and Promotes Neonatal Heart Regeneration

    Researchers suggested that the increase in glucose metabolism promotes cardiac regeneration in neonatal mouse heart.
    [Scientific Reports]

    Full Article

    Aligned and Electrically Conductive 3D Collagen Scaffolds for Skeletal Muscle Tissue Engineering

    Biomaterial-based tissue engineering approaches to repair skeletal muscle are limited due to difficulties combining 3D structural alignment and electrical conductivity. Here, scientists successfully produced aligned and electrically conductive 3D collagen scaffolds using a freeze-drying approach.
    [Biomaterials Science]

    AbstractGraphical Abstract

    Differential Regulation of Autophagy by STAU1 in Alveolar Rhabdomyosarcoma and Non‐Transformed Skeletal Muscle Cells

    The authors assessed the impact of Staufen1 (STAU1) expression modulation in ARMS cell lines, non-transformed skeletal muscle cells and STAU1-transgenic mice using complementary techniques.
    [Cellular Oncology]

    Abstract

    The Regulation of Polyamine Pathway Proteins in Models of Skeletal Muscle Hypertrophy and Atrophy – a Potential Role for mTORC1

    Scientists showed that polyamine pathway enzymes were differentially regulated in models of altered mechanical and metabolic stress, and that Amd1 and SpdSyn were, in part, regulated in a mTORC1-dependent manner.
    [American Journal of Physiology-Cell Physiology]

    Abstract

    circACTA2 Mediates Ang II-Induced VSMC Senescence by Modulation of the Interaction of ILF3 with CDK4 mRNA

    A model of Ang II-induced vascular smooth muscle cell (VSMC) senescence and the renal artery of hypertensive patients were used to investigate the roles and mechanisms of circACTA2 and ILF3 in VSMC senescence. Investigators showed that circACTA2 expression was elevated in Ang II-stimulated VSMCs and in the vascular walls of hypertensive patients.
    [Aging]

    Full Article

    PDGF-Mediated Activation of CREB in Vascular Smooth Muscle Cells Alters Cell Cycling Via Rb, FoxO1 and p27kip1

    Researchers show CREB phosphorylation was required for smooth muscle cell proliferation in response to platelet-derived growth factor (PDGF). This phenotypic change required CBP and was mediated by Cyclin D1 and p27kip as a result of changes in FoxO1 activity.
    [Experimental Cell Research]

    AbstractGraphical Abstract

    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    REVIEWS

    Evolving Roles of Muscle-Resident Fibro-Adipogenic Progenitors in Health, Regeneration, Neuromuscular Disorders, and Aging

    The authors review the current knowledge of fibro-adipogenic progenitor function on muscle homeostatic integrity, regeneration, repair, and aging. They also discuss how scar-forming pathologies and disorders lead to dysregulations in their behavior and plasticity and how these stromal cells can control the onset and severity of muscle loss in disease.
    [Frontiers in Physiology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Arrowhead Announces ARO-DUX4 as First Muscle Targeted RNAi Candidate Using TRiMTM Platform

    Arrowhead Pharmaceuticals, Inc. announced ARO-human double homeobox 4 (DUX4) as Arrowhead’s first muscle targeted investigational RNAi therapeutic candidate to utilize its proprietary Targeted RNAi Molecule (TRIMTM) platform. ARO-DUX4 is designed to target the gene that encodes human DUX4 protein as a potential treatment for patients with facioscapulohumeral muscular dystrophy .
    [Arrowhead Pharmaceuticals]

    Press Release

    FEATURED EVENT

    6th World Congress of the Tissue Engineering and Regenerative Medicine International Society

    November 15 – 19, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Scientist – Muscle Tissue Engineering

    Aspect Biosystems – Vancouver, British Columbia, Canada

    Research Laboratory Tech Associate – Muscular Dystrophies

    University of Michigan – Ann Arbor, Michigan, United States

    Associate Researcher – Developmental and Regenerative Biology

    Mount Sinai Health System – New York, New York, United States

    Life Sciences Research Professional – Muscle Stem Cell

    Stanford University – Stanford, California, United States

    Professor or Associate Professor – Rheumatology

    The University of Utah School of Medicine – Salt Lake City, Utah, United States

    > See All Jobs

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