Muscle Cell News Volume 6.16 | May 10 2021

May 12, 2022

MUSCN 6.16 | May 10 2021

Muscle Cell News by STEMCELL Technologies

Vol. 6.16 – 10 May, 2021

TOP STORY

Integrin α2β1 Regulates Collagen I Tethering to Modulate Hyperresponsiveness in Reactive Airway Disease Models

Researchers showed that another member of the integrin superfamily, integrin α2β1, was present in airway smooth muscle and capable of regulating force transmission via cellular tethering to the matrix protein collagen I, and to a lesser degree, laminin-111.
[Journal of Clinical Investigation]

Abstract Full Article

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PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

PINK1 Contained in huMSC-Derived Exosomes Prevents Cardiomyocyte Mitochondrial Calcium Overload in Sepsis via Recovery of Mitochondrial Ca²⁺ Efflux

Investigators elucidated the mechanism of sepsis-induced myocardial injury and examined the value of human umbilical cord mesenchymal stem cells (huMSCs) for protecting cardiac function in sepsis.
[Stem Cell Research & Therapy]

Full Article

PSMB4 Inhibits Cardiomyocyte Apoptosis via Activating NF-κB Signaling Pathway during Myocardial Ischemia/Reperfusion Injury

In vitro, neonatal ventricle cardiomyocyte hypoxia/reoxygenation model was constructed to mimic myocardial ischemia/reperfusion. Proteasome subunit beta type-4 (PSMB4) silence promoted cardiomyocyte apoptosis and IκBα expression, inhibited the activation of NF-κB.
[Journal of Molecular Histology]

Abstract

SKELETAL MUSCLE CELLS

Specialized Nutrition Improves Muscle Function and Physical Activity without Affecting Chemotherapy Efficacy in c26 Tumor‐Bearing Mice

Scientists showed that specialized nutritional support could be used to maintain muscle function and physical activity levels during chemotherapy without increasing tumor viability.
[Journal of Cachexia Sarcopenia and Muscle]

Full Article

Autoregulation of Insulin Receptor Signaling through MFGE8 and the αvβ5 Integrin

Investigators showed that acute blockade of the milk fat globule epidermal growth factor like 8 (MFGE8/β5) pathway enhanced while acute augmentation dampened insulin-stimulated glucose uptake.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Three-Dimensional Tissue-Engineered Human Skeletal Muscle Model of Pompe Disease

Researchers reported a 3D primary human skeletal muscle model of infantile-onset Pompe disease that recapitulated hallmark pathological features including reduced GAA enzyme activity, elevated glycogen content and lysosome abundance, and increased sensitivity of muscle contractile function to metabolic stress.
[Communications Biology]

Full Article

The Effects of Exercise Training on Kinesin and GAP-43 Expression in Skeletal Muscle Fibers of STZ-Induced Diabetic Rats

Scientists investigated the beneficial effects of endurance training on growth Associated Protein 43 (GAP-43) and Kinesin Family Member 5B (KIF5B) expression in gastrocnemius muscle of streptozotocin – induced diabetic rats.
[Scientific Reports]

Full Article

SMOOTH MUSCLE CELLS

Acute Cigarette Smoke or Extract Exposure Rapidly Activates TRPA1-Mediated Calcium Influx in Primary Human Airway Smooth Muscle Cells

The authors showed that transient receptor potential ankyrin 1 (TRPA1) was likely an important link between cigarette smoke (CS) /cigarette smoke extract (CSE) exposure and airway hyperresponsiveness, and speculated that acute CS/CSE-induced Ca²⁺ influx could lead to exacerbated airway smooth muscle contraction and potentially initiate further chronic pathological effects of tobacco smoke.
[Scientific Reports]

Full Article

Uraemic Extracellular Vesicles Augment Osteogenic Transdifferentiation of Vascular Smooth Muscle Cells via Enhanced AKT Signaling and PiT-1 Expression

Researchers investigated whether extracellular vesicles derived from uraemic milieu‐stimulated endothelial cells and derived from uraemic rats impacted the osteogenic transdifferentiation/calcification of vascular smooth muscle cells.
[Journal of Cellular and Molecular Medicine]

Full Article

Virtual Conference Exhibition: Pluripotent Stem Cells

REVIEWS

Interplay between Inflammation and Thrombosis in Cardiovascular Pathology

Scientists discuss how the synergy between inflammation and thrombosis drives thrombotic diseases. They focus on the huge potential of anti-inflammatory strategies to target cardiovascular pathologies.
[Nature Reviews Cardiology]

Full Article

Mechanisms of Exercise as a Preventative Measure to Muscle Wasting

The authors focus on the role of exercise in altering the molecular landscape of skeletal muscle in a manner that improves or maintains its health and function in the presence of unloading or disease.
[American Journal of Physiology-Cell Physiology]

Abstract

INDUSTRY AND POLICY NEWS

HeartFlow and MedAxiom Announce Collaboration to Improve Care Delivery for Patients with Coronary Artery Disease

HeartFlow, Inc. announced a collaboration to improve cardiovascular care for patients with coronary artery disease.
[HeartFlow, Inc. (BusinessWire, Inc.)]

Press Release

FEATURED EVENT

Integrin α2β1 Regulates Collagen I Tethering to Modulate Hyperresponsiveness in Reactive Airway Disease Models

PINK1 Contained in huMSC-Derived Exosomes Prevents Cardiomyocyte Mitochondrial Calcium Overload in Sepsis via Recovery of Mitochondrial Ca²⁺ Efflux

PSMB4 Inhibits Cardiomyocyte Apoptosis via Activating NF-κB Signaling Pathway during Myocardial Ischemia/Reperfusion Injury

Specialized Nutrition Improves Muscle Function and Physical Activity without Affecting Chemotherapy Efficacy in c26 Tumor‐Bearing Mice

Autoregulation of Insulin Receptor Signaling through MFGE8 and the αvβ5 Integrin

Three-Dimensional Tissue-Engineered Human Skeletal Muscle Model of Pompe Disease

The Effects of Exercise Training on Kinesin and GAP-43 Expression in Skeletal Muscle Fibers of STZ-Induced Diabetic Rats

Acute Cigarette Smoke or Extract Exposure Rapidly Activates TRPA1-Mediated Calcium Influx in Primary Human Airway Smooth Muscle Cells

Uraemic Extracellular Vesicles Augment Osteogenic Transdifferentiation of Vascular Smooth Muscle Cells via Enhanced AKT Signaling and PiT-1 Expression

Interplay between Inflammation and Thrombosis in Cardiovascular Pathology

Mechanisms of Exercise as a Preventative Measure to Muscle Wasting

HeartFlow and MedAxiom Announce Collaboration to Improve Care Delivery for Patients with Coronary Artery Disease

Precision Oncology: Translating Discovery to the Clinic

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Clinical Research Associate – Clinical Trial Monitor

Postdoctoral Position – Adaptive DNA Hydrogel Materials

Research Scientist – Causes and Prevention of Cardiovascular Disease

Life Sciences Research Professional – Muscle Stem Cell

Professor or Associate Professor – Rheumatology

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