Muscle Cell News Volume 6.17 | May 17 2021

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    2021-05-17 | MUSCN 6.17


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.17 – 17 May, 2021
    TOP STORY

    Cardiac Cell Type–Specific Gene Regulatory Programs and Disease Risk Association

    Investigators defined more than 287,000 candidate cis-regulatory elements (cCREs) in the four chambers of the human heart, which revealed cCREs and candidate transcription factors associated with cardiac cell types in a region-dependent manner and during heart failure.
    [Science Advances]

    Full Article
    Daniel Grey investigates cell death modification as a potential therapy for immune disorders. View his profile.
    PUBLICATIONSRanked by the impact factor of the journal

    Impairment of the ER/Mitochondria Compartment in Human Cardiomyocytes with PLN p.Arg14del Mutation

    Researchers identified impairment of the endoplasmic reticulum/mitochondria compartment without sarcoplasmic dysfunction as a novel disease mechanism underlying phospholamban (PLN) p.Arg14del cardiomyopathy.
    [EMBO Molecular Medicine]

    Full Article

    Identification of Dynamic RNA-Binding Proteins Uncovers a Cpeb4-Controlled Regulatory Cascade during Pathological Cell Growth of Cardiomyocytes

    Scientists identified mRNAs bound to and regulated by cytoplasmic polyadenylation element-binding protein 4 (Cpeb4) in cardiomyocytes. Cpeb4 regulated cardiac remodeling by differential expression of transcription factors.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Circular RNA circACSL1 Aggravated Myocardial Inflammation and Myocardial Injury by Sponging miR-8055 and Regulating MAPK14 Expression

    Investigators determined a novel circRNA, circACSL1, which was significantly upregulated in the acute phase of myocarditis, by using lipopolysaccharide to induce inflammatory responses in the human cardiomyocytes line.
    [Cell Death & Disease]

    Full Article

    Puerarin Protects Cardiomyocytes from Ischemia–Reperfusion Injury by Upregulating LncRNA ANRIL and Inhibiting Autophagy

    Researchers analyzed the roles of puerarin and LncRNA ANRIL in myocardial ischemia–reperfusion injury. After cell transfection, the effects of overexpressed and knockdown of ANRIL on cardiomyocytes and hypoxia/reperfusion-injured cardiomyocytes were examined by rescue experiments.
    [Cell and Tissue Research]

    Abstract

    Decreased YAP Activity Reduces Proliferative Ability in Human Induced Pluripotent Stem Cell of Duchenne Muscular Dystrophy Derived Cardiomyocytes

    Scientists investigated yes-associated protein (YAP) activity using disease-specific induced pluripotent stem cell derived cardiomyocytes in Duchenne muscular dystrophy.
    [Scientific Reports]

    Full Article

    A Predictive In Vitro Risk Assessment Platform for Pro-Arrhythmic Toxicity Using Human 3D Cardiac Microtissues

    The authors used human induced pluripotent stem cell-derived cardiomyocytes and human cardiac fibroblasts in 3D microtissues to create an improved in vitro platform for assessing pro-arrhythmic cardiotoxicity.
    [Scientific Reports]

    Full Article

    Bioinspired Electrospun dECM Scaffolds Guide Cell Growth and Control the Formation of Myotubes

    Researchers assessed the potential for electrospun decellularized skeletal muscle extracellular matrix (dECM) with tunable physicochemical properties to control mouse myoblast growth and myotube formation.
    [Science Advances]

    Full Article

    Direct Contribution of Skeletal Muscle Mesenchymal Progenitors to Bone Repair

    The authors showed that mesenchymal progenitors residing in skeletal muscle mediated the initial fibrotic response to bone injury and also participated in cartilage and bone formation.
    [Nature Communications]

    Full Article

    Persistent NF-κB Activation in Muscle Stem Cells Induces Proliferation-Independent Telomere Shortening

    Scientists demonstrated that the distinct early telomere shortening of diseased muscle stem cell in both mice and young Duchenne muscular dystrophy patients was associated with aberrant NF-κB activation.
    [Cell Reports]

    Full ArticleGraphical Abstract

    PDGF-PDGFR Network Differentially Regulates, Myogenic Cell Fate, Migration, Proliferation, and Cell Cycle Progression

    The authors explored the platelet-derived growth factor-platelet-derived growth factor receptor (PDGF-PDGFR) gene expression changes and their involvement in skeletal muscle myogenesis and myogenic fate.
    [Cellular Signalling]

    Abstract

    Spermidine Inhibits Vascular Calcification in Chronic Kidney Disease through Modulation of SIRT1 Signaling Pathway

    Alizarin red staining and quantification of calcium content showed that spermidine treatment markedly reduced mineral deposition in both rat and human vascular smooth muscle cells (VSMCs) under osteogenic conditions.
    [Aging Cell]

    Full Article

    Circ_CHFR Promotes PDGF-BB-Induced Proliferation, Invasion and Migration in VSMCs via miR-149-5p/NRP2 Axis

    Researchers exposed human vascular smooth muscle cells to platelet-derived growth factor (PDGF)-bb in vitro to investigate the mechanism of VSMC dysfunction during atherosclerosis.
    [Journal of Cardiovascular Pharmacology]

    Abstract
    Learn how to keep your lab stockroom and cold reagents organized.
    REVIEWS

    Therapeutic Modulation of RNA Splicing in Malignant and Non-Malignant Disease

    Researchers discuss the therapeutic modulation of RNA splicing using Duchenne muscular dystrophy, Becker muscular dystrophy, and spinal muscular atrophy as primary studies.
    [Trends in Molecular Medicine]

    Full Article

    Skeletal Muscle Fibers Count on Nuclear Numbers for Growth

    The authors review recent advances that elucidate the relationship between myonuclear numbers and establishment of myofiber size, and discuss how this new information refines the understanding of the concept of myonuclear domains, the cytoplasmic volumes that each resident myonucleus can support.
    [Seminars in Cell & Developmental Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    ACC 2021: With Amgen Out of the Picture, Cytokinetics Imagines Supporting Role for Omecamtiv in Heart Failure

    Despite the end of their partnership with Amgen, Cytokinetics Inc. will be filing Omecamtiv mecarbil, a selective cardiac myosin activator designed to target the contractile mechanisms of the heart and boost contraction.
    [Cytokinetics, Inc. (Questex, LLC.)]

    Full Article
    FEATURED EVENT

    Society for Developmental Biology 80th Annual Meeting

    July 12 – 16, 2021
    Virtual
    JOB OPPORTUNITIES

    Postdoctoral Fellow – Developmental and Reproductive Biology

    University of Maryland School of Medicine – Baltimore, Maryland, United States

    Postdoctoral Researcher – Cell Fate Engineering

    German Cancer Research Center – Heidelberg, Germany

    Research Scientist – Causes and Prevention of Cardiovascular Disease

    Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States

    Postdoctoral Position – Adaptive DNA Hydrogel Materials

    Johannes Gutenberg University Mainz – Mainz, Germany

    Clinical Research Associate – Clinical Trial Monitor

    National University of Ireland Galway – Galway, Ireland

    > See All Jobs

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