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| Researchers presented how the detyrosination of microtubules in cardiomyocytes was finely tuned by microtubule-affinity regulating kinase 4 (MARK4) to regulate cardiac inotropy and identified MARK4 as a promising therapeutic target for improving cardiac function after myocardial infarction.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators established self-organizing cardioids from human pluripotent stem cells that intrinsically specified, patterned, and morphed into chamber-like structures containing a cavity.
[Cell] |
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| A di-Fmoc-based hydrogelator containing the cell-adhesive Arg–Gly–Asp fragment that formed a mechanically stable, self-healing hydrogel was designed.
[Advanced Materials] |
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| The authors presented a rapid and ultrahigh-resolution methodology for the fundamental study of cardiomyocyte behavior at the cell or subcellular level.
[Science Advances] |
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| Using mass spectrometry, scientists characterized the myofilament chaperone-assisted selective autophagy interactome in the human heart and identified eight clients of BAG3-mediated protein turnover.
[Nature Communications] |
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| The role of human fibronectin impairment in muscle cell pathology was investigated in patient-derived fukutin-related protein (FKRP)-deficient primary myoblast cells.
[Nature Communications] |
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| Scientists showed that proper myoblast differentiation and muscle regeneration were regulated by the circadian master regulators Per1 and Per2. Their depletion suppressed myoblast differentiation in vitro and muscle regeneration in vivo.
[Journal of Cell Biology] |
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| Investigators presented evidence that during intramembranous bone formation osteoprogenitor cell proliferation was controlled by Notch signaling, while differentiation was initiated by activation of canonical Wnt signaling.
[npj Regenerative Medicine] |
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| Researchers aimed to characterize the functions of Tet proteins in muscle regeneration, and found that Tet2 regulated myoblast differentiation and fusion, while its loss led to severe muscle regeneration defects.
[Cell Death & Disease] |
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| The authors investigated the role of furin, a proprotein convertase that regulated the activation and inactivation of multiple proteins, in regulating inflammation in isolated canine airway smooth muscle tissues.
[American Journal of Physiology-Lung Cellular and Molecular Physiology] |
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| Researchers found that stress-induced premature senescence and stable expression of a telomeric repeat-binding factor 2 protein mutant induced senescence of human vascular smooth muscle cells, associated with persistent telomeric DNA damage.
[Communications Biology] |
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| Investigators uncovered a novel mechanism whereby the miR-378c-Sterile Alpha Motif Domain Contraining 1 (Samd1) circuit participated in two key elements of atherosclerosis: vascular smooth muscle cells phenotypic transition and low-density lipoprotein oxidation.
[Scientific Reports] |
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| The authors investigated how progerin affected smooth muscle cell contractility and found that reduced arterial contractility correlated with a decrease in smooth muscle myosin heavy chain mRNA and protein expression.
[Scientific Reports] |
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| Researchers summarize technical and conceptual advancements derived from several publications that, collectively, illuminate new research directions to further explore the role of vascular smooth muscle cells in atherosclerotic disease.
[Circulation] |
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| The authors discuss various spaceflight experiments conducted by the Japan Aerospace Exploration Agency that are gradually revealing the molecular and physiological mechanisms of muscle and bone atrophy under unloaded conditions.
[NPJ Microgravity] |
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| Scientists report the significant progresses that have been made in recent years to engineer muscle tissue-like structures, which aim to increase our understanding of the involvement of the different cell types present in the formation of skeletal muscle and their interactions.
[Veterinary Research] |
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| Scholar Rock, a clinical-stage biopharmaceutical company, announced that the US FDA has granted Fast Track designation for apitegromab, a selective inhibitor of myostatin activation, for the treatment of patients with Spinal Muscular Atrophy.
[Scholar Rock (Business Wire, Inc.)] |
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| June 21 – 22, 2021
Virtual |
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| | NYU Langone Medical Center – New York, New York, United States |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States |
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| | Johannes Gutenberg University Mainz – Mainz, Germany |
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| | University of Maryland School of Medicine – Baltimore, Maryland , United States |
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