Muscle Cell News Volume 6.21 | Jun 21, 2021

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    2021-06-21 | MUSCN 6.21


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.21 – 21 June, 2021
    TOP STORY

    ERRγ Enhances Cardiac Maturation with T-Tubule Formation in Human iPSC-Derived Cardiomyocytes

    Scientists generated human induced pluripotent stem cells (hiPSCs) carrying a TNNI1EmGFP and TNNI3mCherry double reporter to monitor and isolate mature sub-populations during cardiac differentiation, and showed that ERRγ-treated hiPSC-cardiomyocytes (CMs) had a mature cellular property consistent with neonatal CMs.
    [Nature Communications]

    Full Article

    Derive and expand human skeletal muscle progenitors in a serum-free setting using MyoCult™-SF Expansion Supplement Kit (Human)
    PUBLICATIONSRanked by the impact factor of the journal

    Osteocrin, a Novel Myokine, Prevents Diabetic Cardiomyopathy via Restoring Proteasomal Activity

    The authors investigated the role and underlying molecular basis of osteocrin (OSTN) in diabetic cardiomyopathy. Neonatal rat cardiomyocytes were isolated and stimulated with high glucose to verify the role of OSTN in vitro.
    [Cell Death & Disease]

    Full Article

    Emodin Alleviates LPS-Induced Myocardial Injury through Inhibition of NLRP3 Inflammasome Activation

    Researchers investigated the protective effect of emodin on septic myocardial injury and the underlying mechanism. Lipopolysaccharide (LPS)-induced C57BL/6 mice and cardiomyocytes were used as models of sepsis in vivo and in vitro, respectively.
    [Phytotherapy Research]

    Abstract

    Survival Motor Neuron Deficiency Slows Myoblast Fusion through Reduced Myomaker and Myomixer Expression

    Investigators showed that survival motor neuron (SMN)-deficient myoblasts readily fused with wild-type myoblasts, demonstrating fusion competency. Conditioned media from wild type differentiating myoblasts did not rescue the fusion deficit of SMN-deficient cells, suggesting that compromised fusion may have primarily been a result of altered membrane dynamics at the cell surface.
    [Journal of Cachexia Sarcopenia and Muscle]

    Full Article

    CRISPR Mediated Targeting of DUX4 Distal Regulatory Element Represses DUX4 Target Genes Dysregulated in Facioscapulohumeral Muscular Dystrophy

    In an immortalized patient myoblast cell line, researchers demonstrated that targeting DUX4 led to substantial downregulation of not only pathogenic DUX4 transcripts, but also a subset of its target genes that are known biomarkers of facioscapulohumeral muscular dystrophy.
    [Scientific Reports]

    Full Article

    The LIM Domain Protein nTRIP6 Modulates the Dynamics of Myogenic Differentiation

    In an in vitro model of myogenesis, the expression of nTRIP6 was transiently up-regulated at the transition between proliferation and differentiation, whereas that of the cytosolic isoform TRIP6 was not altered.
    [Scientific Reports]

    Full Article

    The Erythropoietin Receptor Expressed in Skeletal Muscle Is Essential for Mitochondrial Biogenesis and Physiological Exercise

    The authors investigated the contribution of the tissue-specific erythropoietin (EPO)-receptor (EpoR) to exercise-induced remodeling of cardiac and skeletal muscle and indicated that the endogenous EPO-EpoR system controlled mitochondrial biogenesis in skeletal muscle.
    [Pflugers Archiv-European Journal of Physiology]

    Full Article

    miR-141-5p Suppresses Vascular Smooth Muscle Cell Inflammation, Proliferation, and Migration via Inhibiting the HMGB1/NF-κB Pathway

    Using human vascular smooth muscle cells (VSMCs) treated by oxidized low-density lipoprotein to establish an atherosclerosis cell model, scientists explored the functional roles and molecular mechanisms of miR-141-5p in VSMCs dysfunction.
    [Journal of Biochemical and Molecular Toxicology]

    Full Article

    Atypical Antipsychotic Olanzapine Inhibits Voltage-Dependent K+ Channels in Coronary Arterial Smooth Muscle Cells

    Electrophysiological recordings were performed in freshly isolated coronary arterial smooth muscle cells to investigate the inhibitory effect of olanzapine on voltage-dependent K+ channels.
    [Pharmacological Reports]

    Abstract

    High Fluid Shear Stress Prevents Atherosclerotic Plaque Formation by Promoting Endothelium Denudation and Synthetic Phenotype of Vascular Smooth Muscle Cells

    Researchers investigated the role of high shear stress (HSS) in atherosclerotic plaque formation. In vitro modeling used human umbilical vein endothelial cells and vascular smooth muscle cells exposed to HSS using a parallel‑plate flow system.
    [Molecular Medicine Reports]

    AbstractFull Article

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    REVIEWS

    Control of Cardiomyocyte Differentiation Timing by Intercellular Signaling Pathways

    The authors discuss the action of signaling pathways in the control of cardiomyocyte differentiation timing, including the Wnt, Fibroblast Growth Factor, Hedgehog, Bone Morphogenetic Protein, Insulin-like Growth Factor, Thyroid Hormone and Hippo pathways.
    [Seminars in Cell & Developmental Biology]

    Abstract

    Inflammation during Post-Injury Skeletal Muscle Regeneration

    Scientists present the interactions that leukocytes develop with the cells present in their vicinity, such as the activation of muscle stem cells and the maturation of newly formed myofibers, and the impact they have on skeletal muscle regeneration.
    [Seminars in Cell & Developmental Biology]

    Full Article

    Signaling Pathways Regulating the Fate of Fibro/Adipogenic Progenitors (FAPs) in Skeletal Muscle Regeneration and Disease

    Investigators provide a detailed overview of the pathways and metabolic routes that can be modulated to halt and redirect their fibro/adipogenic potential while favoring their supportive role in muscle regeneration.
    [FEBS Journal]

    Full Article

    INDUSTRY AND POLICY NEWS

    Five VP&S Teams Awarded Vagelos Precision Medicine Grants

    The annual Vagelos Precision Medicine Pilot Grants have been awarded to five teams of VP&S researchers conducting innovative basic science, translational, and clinical research across multiple diseases, from novel cancer therapeutics to health disparities research.
    [Columbia University Irving Medical Center]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Vascular Malformations: From Fundamental Biology to Therapeutic Opportunities

    October 6 – 8, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cardiac Fibrosis and Valvular Diseases

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Postdoctoral Position – Cardiopulmonary Molecular Biology

    Hannover Medical School – Hannover, Germany

    Postdoctoral Research Associate – Cardiac Remodeling

    University of Nebraska Medical Center – Omaha, Nebraska, United States

    Research Scientist – Causes and Prevention of Cardiovascular Disease

    Harvard T.H. Chan School of Public Health – Boston, Massachusetts, United States

    Postdoctoral Position – Adaptive DNA Hydrogel Materials

    Johannes Gutenberg University Mainz – Mainz, Germany

    > See All Jobs

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