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| Researchers investigated an adeno-associated virus 9–based gene therapy to locally knock down the Hippo pathway gene Salvador in border zone cardiomyocytes in a pig model of ischemia/reperfusion-induced myocardial infarction.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors used in situ cryo-electron tomography to unveil sarcomere contraction in frozen-hydrated neonatal rat cardiomyocytes.
[Nature Communications] |
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| Scientists employed 15- to 16-month-old female and male Ahnak1-knockout and wild-type mice and performed morphometric, biochemical, and bioenergetics assays to evaluate the effects of Ahnak1 on exercise capacity and mitochondrial morphology and function in cardiomyocytes and tibialis anterior muscle.
[Journal of Cachexia Sarcopenia and Muscle] |
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| Investigators demonstrated that deficiency of SIRT1 and SIRT3 in aged mice hearts led to the exacerbated cardiac dysfunction in terms of cardiac systolic dysfunction, cardiomyocytes contractile defection, and abnormal cardiomyocyte calcium flux during ischemia/reperfusion stress.
[Aging Cell] |
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| Researchers demonstrated that cardiomyocyte proliferation greatly contributed to heart regeneration in adult Xenopus tropicalis upon apex resection.
[NPJ Regenerative Medicine] |
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| Ischemia/reperfusion (IR) injury mice with myocardial overexpression GDF11 exhibited a significantly smaller myocardial infarct size, less cardiac remodeling and dysfunction, fewer apoptotic cardiomyocytes, higher telomerase activity, longer telomeres, and higher ATP generation than IR mice treated with an adenovirus carrying a negative control plasmid.
[Cell Death & Disease] |
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| The authors showed that α-actinin-3 played a key role in the regulation of protein synthesis and breakdown signaling in skeletal muscle and influenced muscle mass from early postnatal development.
[Science Advances] |
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| Muscle specific deletion of β-catenin induced in adult mice impaired both exercise and contraction (isolated muscle) induced glucose uptake without affecting running performance or canonical exercise signaling pathways.
[Journal of Physiology] |
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| Investigators elucidated the effects of glutamine (Gln) supplementation on the cellular muscle development of low birth weight and normal birth weight piglets. Cell culture experiments indicated that Gln promoted cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered.
[Scientific Reports] |
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| Scientists examined the influence of endothelial progenitor cells on features of smooth muscle cells pivotal for their impact on injury-induced neointima formation including proliferation, migration, and phenotype switch.
[Thrombosis and Haemostasis] |
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| Researchers investigated the effect of all-trans-retinoic acid, a modulator of smooth muscle cell functions, on coronary artery stenosis in a mouse model of Kawasaki disease.
[Scientific Reports] |
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| Investigators constructed a cell-based luciferase assay system for HIF-1 inhibitors and used this system to identify six HIF-1 inhibitors. Among these inhibitors, the effect of tagitinin C (1) on pulmonary arterial smooth muscle cells was investigated.
[Chembiochem] |
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| Scientists investigated the roles of microRNA‑199a‑5p in varicose veins and in the phenotypic transition of vascular smooth muscle cells.
[Molecular Medicine Reports] |
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| Over the last decade, remarkable progresses have been made on cardiac reprogramming, particularly focusing on how to enhance conversion of fibroblasts to induced cardiomyocyte-like cells in vitro. The author discusses progresses and challenges of cardiac reprogramming in the translational context.
[Seminars in Cell & Developmental Biology] |
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| Investigators provide new cellular and molecular insights in comprehending the origins, definitions, markers, fate, and plasticity of murine and human fibro-adipogenic progenitors in muscle development, homeostasis, regeneration, and repair.
[Skeletal Muscle] |
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| Asklepios BioPharmaceutical, Inc. announced that the US FDA has granted Fast Track Designation for the LION-101 gene therapy program. LION-101 is a novel recombinant adeno-associated virus (AAV) based vector being developed as a one-time intravenous infusion for the treatment of patients with Limb-Girdle Muscular Dystrophy Type 2I/R9.
[Asklepios BioPharmaceutical, Inc.] |
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| Abcuro, Inc. and ImaginAb shared initial results of a study demonstrating the use of ImmunoPET technology to image T cell infiltration of skeletal muscle in patients with inclusion body myositis, an autoimmune disease in which cytotoxic CD8+ T cells chronically attack muscle cells, leading to progressive weakness and severe disability.
[Abcuro, Inc.] |
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| February 27 – March 4, 2022
Ventura, California, United States |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | Stanford University – Palo Alto, California, United States |
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| | University Hospital of Muenster – Münster, Germany |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | Hannover Medical School – Hannover, Germany |
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