Muscle Cell News Volume 6.27 | Aug 9 2021

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    2021-08-09 | MUSCN 6.27


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.27 – 9 August, 2021
    TOP STORY

    Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling

    To explore the key extracellular matrix (ECM) proteins in the maintenance of the contractile phenotype of vascular smooth muscle cells (VSMCs), researchers applied protein-protein interaction network analysis to explore novel ECM proteins associated with the VSMC phenotype.
    [Circulation]

    Abstract


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    PUBLICATIONSRanked by the impact factor of the journal

    Human Sensorimotor Organoids Derived from Healthy and Amyotrophic Lateral Sclerosis Stem Cells Form Neuromuscular Junctions

    Scientists generated sensorimotor organoids containing physiologically functional neuromuscular junctions and applied the model to different subgroups of amyotrophic lateral sclerosis.
    [Nature Communications]

    Full Article

    Responsiveness to Perturbations Is a Hallmark of Transcription Factors That Maintain Cell Identity In Vitro

    The authors developed perturbation panel profiling as a framework for perturbing cells across many conditions and measuring gene expression responsiveness transcriptome-wide.
    [Cell Systems]

    AbstractGraphical Abstract

    Deep Learning Detects Cardiotoxicity in a High-Content Screen with Induced Pluripotent Stem Cell-Derived Cardiomyocytes

    Investigators screened a library of 1280 bioactive compounds and identified those with potential cardiotoxic liabilities in induced pluripotent stem cell-cardiomyocytes using a single-parameter score based on deep learning.
    [eLife]

    Abstract

    HiPS-Endothelial Cells Acquire Cardiac Endothelial Phenotype in Co-Culture With hiPS-Cardiomyocytes

    Single-cell RNA sequencing was performed with human induced pluripotent stem cell-derived cardiomyocytes and endothelial cells in mono- and co-culture.
    [Frontiers in Cell and Developmental Biology]

    Full Article

    Preclinical Characterization of AntagomiR-218 as a Potential Treatment for Myotonic Dystrophy

    Researchers provided preclinical characterization of an antagomiR-218 molecule using the HSALR mouse model and patient-derived myotubes.
    [Molecular Therapy-Nucleic Acids]

    AbstractGraphical Abstract

    CRISPR Gene Editing in Pluripotent Stem Cells Reveals the Function of MBNL Proteins during Human In Vitro Myogenesis

    Scientists generated human-induced pluripotent stem cells depleted in MBNL proteins and evaluated the consequences of their losses on the generation of skeletal muscle cells.
    [Human Molecular Genetics]

    AbstractFull Article

    AUF1 Gene Transfer Increases Exercise Performance and Improves Skeletal Muscle Deficit in Adult Mice

    Using wild type, AUF1 knockout mice and cultured myoblasts, AUF1 supplementation of muscle fibers was found to increase expression of PGC1α, a major effector of skeletal muscle mitochondrial oxidative metabolism.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    Circulating Skeletal Muscle Related microRNAs Profile in Piedmontese Cattle during Different Age

    Comparing new-born with the other age groups, miR-10b, miR-126-5p, miR-143 and miR-146b were significantly up-regulated, whereas miR-21-5p, miR-221, miR-223 and miR-30b-5p were significantly down-regulated.
    [Scientific Reports]

    Full Article

    Probing Tissue Transglutaminase Mediated Vascular Smooth Muscle Cell Aging Using a Novel Transamidation-Deficient Tgm2-C277S Mouse Model

    The authors harnessed CRISPR-Cas9 gene editing technology to introduce a mutation at cysteine 277 in the active site of the mouse Tgm2 gene. In vitro, a remodeling stimulus led to the significant loss of vascular compliance in wild-type mice, but not in the Tgm2-C277S or TG2−/− mice.
    [Cell Death Discovery]

    Full Article

    Extracellular NLRP3 Inflammasome Particles Are Internalized by Human Coronary Artery Smooth Muscle Cells and Induce Pro-Atherogenic Effects

    Fluorescently labeled NLRP3 inflammasome particles were isolated from a mutant NLRP3-YFP cell line and used to treat primary human coronary artery smooth muscle cells for 4 and 24 hours.
    [Scientific Reports]

    Full Article

    AMOTL2 Restrains Transforming Growth Factor-β1-Induced Proliferation and Extracellular Matrix Deposition of Airway Smooth Muscle Cells via the Down-Regulation of YAP1 Activation

    Researchers studied the possible role and mechanism of AMOTL2 in regulating transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells.
    [Environmental Toxicology]

    Abstract

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    REVIEWS

    Nrf2 for Cardiac Protection: Pharmacological Options against Oxidative Stress

    Myocardial ischemia or reperfusion increases the generation of reactive oxygen species from damaged mitochondria, NADPH oxidases, xanthine oxidase, and inflammation.
    [Trends in Pharmacological Sciences]

    Abstract

    Fibro-Adipogenic Progenitors: Versatile Keepers of Skeletal Muscle Homeostasis, beyond the Response to Myotrauma

    The authors review the emerging contribution of fibro-adipogenic progenitors to skeletal muscle responses to motor neuron injuries and to systemic physiological or pathological metabolic perturbations.
    [Seminars in Cell & Developmental Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Avidity Biosciences Receives IND Clearance from FDA to Proceed with the Phase I/II MARINAâ„¢ Trial of AOC 1001 in Adults with Myotonic Dystrophy (DM1)

    Avidity Biosciences, Inc. announced that the US FDA cleared the company to proceed with the Phase I/II MARINAâ„¢ clinical trial of AOC 1001 in adults with DM1. AOC 1001 is designed to address the root cause of DM1 by reducing levels of DMPK, the disease-related mRNA.
    [Avidity Biosciences, Inc.]

    Press Release

    PharmaTher Granted FDA Orphan Drug Designation For Ketamine To Treat Amyotrophic Lateral Sclerosis

    PharmaTher Holdings Ltd. announced that the FDA has granted orphan drug designation for ketamine in the treatment of Amyotrophic Lateral Sclerosis, also known as Lou Gehrig’s disease.
    [PharmaTher Holdings Ltd.]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Cancer Immunometabolism

    November 29 – December 1, 2021
    Barcelona, Spain

    > See All Events

    JOB OPPORTUNITIES

    Postdocotral Fellow – Liquid Chromatography-Mass Spectrometry

    Buck Institute for Research on Aging – Novato, California, United States

    Postdoctoral Associate – Extracellular Matrix and Inflammation

    Baylor College of Medicine – Houston, Texas, United States

    Manager – Organoid Core Facility

    Weill Cornell Medicine – New York, New York, United States

    Research Assistant – Pharmacology

    The Scripps Research Institute – La Jolla, California, United States

    Postdoctoral Fellow – Skeletal Muscle Aging

    Pompeu Fabra University – Barcelona, Spain

    > See All Jobs

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