Muscle Cell News Volume 6.28 | Aug 16 2021

May 12, 2022

2021-08-16 | MUSCN 6.28

Muscle Cell News by STEMCELL Technologies

Vol. 6.28 – 16 August, 2021

TOP STORY

A MicroRNA Program Regulates the Balance between Cardiomyocyte Hyperplasia and Hypertrophy and Stimulates Cardiac Regeneration

Researchers reported that the miR-106b~25 cluster was higher expressed in the early postnatal myocardium and decreased in expression towards adulthood, especially under conditions of overload, and orchestrated the transition of cardiomyocyte hyperplasia towards cell cycle arrest and hypertrophy by virtue of its targetome.
[Nature Communications]

Abstract

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PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

Myocardial Fibrosis Reversion via rhACE2-Electrospun Fibrous Patch for Ventricular Remodeling Prevention

By multiple in vitro studies, the rhACE2 patch demonstrated effectiveness in reducing cardiomyocyte apoptosis under hypoxia stress and inhibiting cardiac fibroblasts proliferation, which gave evidence for its in vivo efficacy.
[NPJ Regenerative Medicine]

Abstract

Cardiomyocyte Peroxisome Proliferator-Activated Receptor α Is Essential for Energy Metabolism and Extracellular Matrix Homeostasis during Pressure Overload-Induced Cardiac Remodeling

Transcriptome analysis showed that genes related to fatty acid metabolism were dramatically downregulated, but genes critical for glycolysis were markedly upregulated in PparaΔCM hearts.
[Acta Pharmacologica Sinica]

Abstract

A Comprehensive Analysis of Gene Expression Changes in a High Replicate and Open-Source Dataset of Differentiating hiPSC-Derived Cardiomyocytes

Researchers performed a comprehensive analysis of the transcriptional changes occurring during human iPSC (hiPSC) differentiation to cardiomyocytes. Using single cell RNA-seq, they sequenced > 20,000 single cells from 55 independent samples representing two differentiation protocols and multiple hiPSC lines.
[Scientific Reports]

Full Article

Carbonic Anhydrase III Attenuates Hypoxia-Induced Apoptosis and Activates PI3K/Akt/mTOR Pathway in H9c2 Cardiomyocyte Cell Line

To investigate the role of carbonic anhydrase III in the apoptosis of myocytes under hypoxic conditions and facilitate the strategy for treating hypoxia-induced damage, in vitro experiments in H9c2 were employed.
[Cardiovascular Toxicology]

Abstract

SKELETAL MUSCLE CELLS

Sestrins Regulate Muscle Stem Cell Metabolic Homeostasis

Investigators showed that SESTRIN1,2 loss resulted in hyperactivation of the mTORC1 complex, increased propensity to enter the cell cycle, and shifted in metabolic flux. Aged SESTRIN1,2 knockout mice exhibited loss of muscle stem cells and a reduced ability to regenerate injured muscle.
[Stem Cell Reports]

Full Article

MyD88-Mediated Signaling Intercedes in Neurogenic Muscle Atrophy through Multiple Mechanisms

Researchers found that specific inhibition of MyD88 reduced the activation of canonical nuclear factor-kappa pathway and expression of receptors for inflammatory cytokines in denervated muscle.
[FASEB Journal]

Abstract

SMOOTH MUSCLE CELLS

Soft Robotic Constrictor for In Vitro Modeling of Dynamic Tissue Compression

Scientists demonstrated cyclic compression of primary human endothelial cells, fibroblasts, and smooth muscle cells to show physiological changes in their morphology due to applied forces.
[Scientific Reports]

Full Article

Investigation into the Role of Stmn2 in Vascular Smooth Muscle Phenotype Transformation during Vascular Injury via RNA Sequencing and Experimental Validation

Researchers examined the effects of Stmn2 on phenotype transformation of vascular smooth muscle in vascular injury via RNA sequencing and experimental validation.
[Environmental Science and Pollution Research]

Abstract

Metformin Inhibits Cholesterol-Induced Adhesion Molecule Expression via Activating the AMPK Signaling Pathway in Vascular Smooth Muscle Cells

Human vascular smooth muscle cells were loaded with cholesterol and different concentrations of metformin. The expression levels of adhesion molecules were assessed via reverse transcription‑quantitative PCR and western blotting.
[Molecular Medicine Reports]

Abstract

miR-125a-5p and miR-7 Inhibits the Proliferation, Migration and Invasion of Vascular Smooth Muscle Cell by Targeting EGFR

Scientists elucidated the functions of miR‑125a‑5p and miR‑7 in vascular smooth muscle cells and investigated the associated molecular mechanisms.
[Molecular Medicine Reports]

Abstract

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REVIEWS

Skeletal Muscle Atrophy: From Mechanisms to Treatments

Skeletal muscle atrophy is characterized by weakening, shrinking, and decreasing muscle mass and fiber cross-sectional area at the histological level. The authors review the mechanisms and treatment strategies for skeletal muscle atrophy.
[Pharmacological Research]

Abstract Graphical Abstract

INDUSTRY AND POLICY NEWS

Edgewise Receives US FDA Fast Track Designation for EDG-5506 for the Treatment of Individuals with Becker Muscular Dystrophy (BMD)

Edgewise Therapeutics, Inc. announced that the US FDA has granted Fast Track designation for EDG-5506 for the treatment of individuals with BMD. EDG-5506, a selective, small molecule myosin inhibitor designed to protect injury-susceptible fast skeletal muscle fibers in DMD and BMD, is advancing in a Phase I clinical trial.
[Edgewise Therapeutics, Inc.]

Press Release

FEATURED EVENT

A MicroRNA Program Regulates the Balance between Cardiomyocyte Hyperplasia and Hypertrophy and Stimulates Cardiac Regeneration

Myocardial Fibrosis Reversion via rhACE2-Electrospun Fibrous Patch for Ventricular Remodeling Prevention

Cardiomyocyte Peroxisome Proliferator-Activated Receptor α Is Essential for Energy Metabolism and Extracellular Matrix Homeostasis during Pressure Overload-Induced Cardiac Remodeling

A Comprehensive Analysis of Gene Expression Changes in a High Replicate and Open-Source Dataset of Differentiating hiPSC-Derived Cardiomyocytes

Carbonic Anhydrase III Attenuates Hypoxia-Induced Apoptosis and Activates PI3K/Akt/mTOR Pathway in H9c2 Cardiomyocyte Cell Line

Sestrins Regulate Muscle Stem Cell Metabolic Homeostasis

MyD88-Mediated Signaling Intercedes in Neurogenic Muscle Atrophy through Multiple Mechanisms

Soft Robotic Constrictor for In Vitro Modeling of Dynamic Tissue Compression

Investigation into the Role of Stmn2 in Vascular Smooth Muscle Phenotype Transformation during Vascular Injury via RNA Sequencing and Experimental Validation

Metformin Inhibits Cholesterol-Induced Adhesion Molecule Expression via Activating the AMPK Signaling Pathway in Vascular Smooth Muscle Cells

miR-125a-5p and miR-7 Inhibits the Proliferation, Migration and Invasion of Vascular Smooth Muscle Cell by Targeting EGFR

Skeletal Muscle Atrophy: From Mechanisms to Treatments

Edgewise Receives US FDA Fast Track Designation for EDG-5506 for the Treatment of Individuals with Becker Muscular Dystrophy (BMD)

ISSCR: Stem Cells – From Basic Science to Clinical Translation

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Postdoctoral Associate – Extracellular Matrix and Inflammation

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