| Vol. 6.29 – 23 August, 2021 |
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| Investigators reported the reprogramming of mouse tail-tip fibroblasts simultaneously into cells resembling cardiomyocytes, endothelial cells or smooth muscle cells using the microRNA mimic miR-208b-3p, ascorbic acid and bone morphogenetic protein 4, as well as the formation of tissue-like structures formed by the directly reprogrammed cells. [Nature Biomedical Engineering] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that differentiating human iPSC-derived lateral plate mesoderm with BMP4, RA and VEGF could generate a premature form of epicardial cells expressing WT1, TBX18, SEMA3D, and SCX within seven days. [Nature Communications] |
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| The authors indicated that CMDL-1 may have played an anti-apoptotic role in doxorubicin (DOX) cardiotoxicity by regulating Drp1 S637 phosphorylation. Thus, CMDL-1 may have served as a potential therapeutic target in DOX cardiotoxicity. [Molecular Therapy-Nucleic Acids] |
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| Scientists screened for targets for the treatment of ischemia-reperfusion injury using a combination of shRNA and drug library analyses in HL-1 mouse cardiomyocytes subjected to hypoxia and reoxygenation. [Scientific Reports] |
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| Researchers found that bisphenol A (BPA) exposure altered cardiac function in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Acute BPA exposure in hiPSC-CMs resulted in reduced field potential, as measured by multielectrode array [Toxicology and Applied Pharmacology] |
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| Investigators showed that DHX36, a helicase that unwinds RNA G-quadruplex structures, was essential for muscle regeneration by regulating satellite cells expansion. [Nature Communications] |
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| Scientists dissected the transcriptional and epigenetic dynamics of mouse fibroblasts undergoing reprogramming to either myotubes or induced myogenic progenitor cells using a MyoD-inducible transgenic model. [Genes & Development] |
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| Using gene silencing strategies, and the small molecule Musashi-2 (MSI2)-inhibitor Ro 08-2750, the authors demonstrated that reducing MSI2 levels or activity boosted miR-7 expression, repressed excessive autophagy, and downregulated atrophy-related genes of the UPS system. [Molecular Therapy-Nucleic Acids] |
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| Researchers described a method that allowed the use of frozen human skeletal muscle biopsies to simultaneously isolate and grow satellite cells and fibroadipogenic progenitors cells from healthy or dystrophic patients. [FASEB Journal] |
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| To investigate the role of R349P Des in mechanical loading, scientists stimulated the sciatic nerve of wild-type littermates and animals carrying the mutation causing a lengthening contraction of the dorsi flexor muscles. [FASEB Journal] |
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| The authors showed a xanthene derivative, DS20060511, induced glucose transporter 4 (GLUT4) translocation to the skeletal muscle cell surface, thereby stimulating glucose uptake into the tissue. [Communications Biology] |
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| Investigators showed that vascular smooth muscle cells (VSMCs) in brains of Alzheimer’s disease patients and animal models of the disease were deficient in multiple VSMC-contractile markers which correlated with the Tau accumulation in brain arterioles. [iScience] |
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| As opposed to symptomatic uropathogenic E. coli-infected mice, treated mice showed reduced myosin light chain-2 phosphorylation, a marker of prostate smooth muscle contraction. [American Journal of Physiology-Renal Physiology] |
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| Scientists examine the evidence for altered mitochondrial dynamics as a mechanism in age and obesity-associated loss of skeletal muscle function, with a particular focus on the available human data. [Trends in Molecular Medicine] |
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| AB Science SA announced that it has received the first authorization to resume patient enrollment in the confirmatory Phase III study of masitinib in amyotrophic lateral sclerosis (ALS). Masitinib is a orally administered tyrosine kinase inhibitor that targets mast cells and macrophages, important cells for immunity, through inhibiting a limited number of kinases. [AB Science SA] |
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| Kezar Life Sciences, Inc. announced that PRESIDIO, its Phase II clinical trial to evaluate the safety and efficacy of KZR-616 for the treatment of polymyositis and dermatomyositis completed the target enrollment of 24 subjects. [Kezar Life Sciences, Inc. (BusinessWire, Inc.)] |
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| October 14, 2021 Wädenswil, Switzerland |
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| Stanford University – La Jolla, California, United States |
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| The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| The Scripps Research Institute – La Jolla, California, United States |
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| Buck Institute for Research on Aging – Novato, California, United States |
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| Weill Cornell Medicine – New York, New York, United States |
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