Muscle Cell News Volume 6.29 | Aug 23 2021

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    2021-08-23 | MUSCN 6.29


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.29 – 23 August, 2021
    TOP STORY

    Regeneration of Infarcted Mouse Hearts by Cardiovascular Tissue Formed via the Direct Reprogramming of Mouse Fibroblasts

    Investigators reported the reprogramming of mouse tail-tip fibroblasts simultaneously into cells resembling cardiomyocytes, endothelial cells or smooth muscle cells using the microRNA mimic miR-208b-3p, ascorbic acid and bone morphogenetic protein 4, as well as the formation of tissue-like structures formed by the directly reprogrammed cells.
    [Nature Biomedical Engineering]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Human iPS-Derived Pre-Epicardial Cells Direct Cardiomyocyte Aggregation Expansion and Organization In Vitro

    Researchers showed that differentiating human iPSC-derived lateral plate mesoderm with BMP4, RA and VEGF could generate a premature form of epicardial cells expressing WT1, TBX18, SEMA3D, and SCX within seven days.
    [Nature Communications]

    Full Article

    Cardiomyocyte Mitochondrial Dynamic-Related lncRNA 1 (CMDL-1) May Serve as a Potential Therapeutic Target in Doxorubicin Cardiotoxicity

    The authors indicated that CMDL-1 may have played an anti-apoptotic role in doxorubicin (DOX) cardiotoxicity by regulating Drp1 S637 phosphorylation. Thus, CMDL-1 may have served as a potential therapeutic target in DOX cardiotoxicity.
    [Molecular Therapy-Nucleic Acids]

    Full ArticleGraphical Abstract

    Combined Genetic and Chemical Screens Indicate Protective Potential for EGFR Inhibition to Cardiomyocytes under Hypoxia

    Scientists screened for targets for the treatment of ischemia-reperfusion injury using a combination of shRNA and drug library analyses in HL-1 mouse cardiomyocytes subjected to hypoxia and reoxygenation.
    [Scientific Reports]

    Full Article

    Cardiac Toxicity from Bisphenol A Exposure in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

    Researchers found that bisphenol A (BPA) exposure altered cardiac function in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Acute BPA exposure in hiPSC-CMs resulted in reduced field potential, as measured by multielectrode array
    [Toxicology and Applied Pharmacology]

    Abstract

    Translational Control by DHX36 Binding to 5′UTR G-Quadruplex Is Essential for Muscle Stem-Cell Regenerative Functions

    Investigators showed that DHX36, a helicase that unwinds RNA G-quadruplex structures, was essential for muscle regeneration by regulating satellite cells expansion.
    [Nature Communications]

    Full Article

    Dissecting Dual Roles of MyoD during Lineage Conversion to Mature Myocytes and Myogenic Stem Cells

    Scientists dissected the transcriptional and epigenetic dynamics of mouse fibroblasts undergoing reprogramming to either myotubes or induced myogenic progenitor cells using a MyoD-inducible transgenic model.
    [Genes & Development]

    AbstractPress Release

    Musashi-2 Contributes to Myotonic Dystrophy Muscle Dysfunction by Promoting Excessive Autophagy through Repression of miR-7 Biogenesis

    Using gene silencing strategies, and the small molecule Musashi-2 (MSI2)-inhibitor Ro 08-2750, the authors demonstrated that reducing MSI2 levels or activity boosted miR-7 expression, repressed excessive autophagy, and downregulated atrophy-related genes of the UPS system.
    [Molecular Therapy-Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    Isolation of Human Fibroadipogenic Progenitors and Satellite Cells from Frozen Muscle Biopsies

    Researchers described a method that allowed the use of frozen human skeletal muscle biopsies to simultaneously isolate and grow satellite cells and fibroadipogenic progenitors cells from healthy or dystrophic patients.
    [FASEB Journal]

    AbstractFull Article

    A Mutation in Desmin Makes Skeletal Muscle Less Vulnerable to Acute Muscle Damage after Eccentric Loading in Rats

    To investigate the role of R349P Des in mechanical loading, scientists stimulated the sciatic nerve of wild-type littermates and animals carrying the mutation causing a lengthening contraction of the dorsi flexor muscles.
    [FASEB Journal]

    AbstractFull Article

    A Xanthene Derivative, DS20060511, Attenuates Glucose Intolerance by Inducing Skeletal Muscle-Specific GLUT4 Translocation in Mice

    The authors showed a xanthene derivative, DS20060511, induced glucose transporter 4 (GLUT4) translocation to the skeletal muscle cell surface, thereby stimulating glucose uptake into the tissue.
    [Communications Biology]

    Full Article

    Dysfunctional Vascular Smooth Muscle Cells Contribute to Neuroinflammation and Tau Hyperphosphorylation in Alzheimer’s Disease

    Investigators showed that vascular smooth muscle cells (VSMCs) in brains of Alzheimer’s disease patients and animal models of the disease were deficient in multiple VSMC-contractile markers which correlated with the Tau accumulation in brain arterioles.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Mast Cell Function in Prostate Inflammation, Fibrosis, and Smooth Muscle Cell Dysfunction

    As opposed to symptomatic uropathogenic E. coli-infected mice, treated mice showed reduced myosin light chain-2 phosphorylation, a marker of prostate smooth muscle contraction.
    [American Journal of Physiology-Renal Physiology]

    Abstract

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    REVIEWS

    Skeletal Muscle Mitochondrial Network Dynamics in Metabolic Disorders and Aging

    Scientists examine the evidence for altered mitochondrial dynamics as a mechanism in age and obesity-associated loss of skeletal muscle function, with a particular focus on the available human data.
    [Trends in Molecular Medicine]

    Abstract

    INDUSTRY AND POLICY NEWS

    AB Science Announces That It Has Received the First Authorization to Resume Patient Enrollment in the Confirmatory Phase III Study of Masitinib (AB19001) in ALS

    AB Science SA announced that it has received the first authorization to resume patient enrollment in the confirmatory Phase III study of masitinib in amyotrophic lateral sclerosis (ALS). Masitinib is a orally administered tyrosine kinase inhibitor that targets mast cells and macrophages, important cells for immunity, through inhibiting a limited number of kinases.
    [AB Science SA]

    Press Release

    Kezar Life Sciences Announces Completion of Enrollment of Its Phase II PRESIDIO Clinical Trial of KZR-616 in Polymyositis and Dermatomyositis

    Kezar Life Sciences, Inc. announced that PRESIDIO, its Phase II clinical trial to evaluate the safety and efficacy of KZR-616 for the treatment of polymyositis and dermatomyositis completed the target enrollment of 24 subjects.
    [Kezar Life Sciences, Inc. (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    TEDD Annual Meeting: Cross-Industrial Applications of Organotypic Models

    October 14, 2021
    Wädenswil, Switzerland

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    JOB OPPORTUNITIES

    Postdoctoral Research Fellow – Cardiac and Endothelial Cell Function

    Stanford University – La Jolla, California, United States

    Postdoctoral Fellow – Physiology

    The University of Tennessee Health Science Center – Memphis, Tennessee, United States

    Research Assistant – Pharmacology

    The Scripps Research Institute – La Jolla, California, United States

    Postdoctoral Fellow – Liquid Chromatography-Mass Spectrometry

    Buck Institute for Research on Aging – Novato, California, United States

    Manager – Organoid Core Facility

    Weill Cornell Medicine – New York, New York, United States

    > See All Jobs

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