 | | Vol. 6.31 – 13 September, 2021 |
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| The authors showed that postnatal osteoblasts arose primarily from chondrocytes before adolescence and from Lepr+ bone marrow stromal cells after adolescence. Thus, short-term developmental skeletal progenitors generated the long-term adult skeletal progenitors.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers revealed an intrinsic glutamatergic transmitter system directly modulating excitability and conductivity of atrial cardiomyocytes through controlling ionotropic glutamate receptor-gated currents.
[Cell Research] |
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| Scientists directly assessed the frequency of DNA damage of the murine myocardium during natural aging and in hearts from four mouse models of premature aging.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators co-delivered CRISPR-Cas9 and a donor DNA sequence to insert the missing human exon 52 into its corresponding position within the Duchenne muscular dystrophy gene and achieved full-length dystrophin correction in skeletal and cardiac muscle.
[Molecular Therapy] |
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| Researchers found that a dietary saturated fatty acid, palmitate increased intracellular cAMP synthesis through the palmitoylation of soluble adenylyl cyclase in cardiomyocytes.
[Cell Death & Disease] |
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| Rat cardiomyocyte cell line H9C2 and primary rat cardiac fibroblasts were cultured in conditioned media generated from epicardial adipose tissue (EAT) of rats in the myocardial infarction four-week group (EAT-CM). Functionally, EAT-CM enlarged the cell surface area of H9C2 cells and reinforced cardiac fibroblast activation into myofibroblasts by elevating intracellular reactive oxygen species levels.
[Cell Death & Disease] |
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| Scientists generated a monoclonal human anti-latent transforming growth factor β binding protein 4 (LTBP4) antibody directed toward LTBP4’s hinge region. In vitro, anti-LTBP4 bound LTBP4 protein and reduced LTBP4 proteolytic cleavage. In isolated myofibers, the LTBP4 antibody stabilized the sarcolemma from injury.
[Science Translational Medicine] |
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| The authors combined transcriptome analysis and modeling of Duchenne muscular dystrophy (DMD) patient-derived neuromuscular circuits with CRISPR-corrected isogenic controls in compartmentalized microdevices and showed that neuromuscular junction volumes and optogenetic motor neuron–stimulated myofiber contraction were compromised in DMD neuromuscular circuits.
[Science Advances] |
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| Human induced pluripotent stem-derived skeletal muscle cells from a healthy donor and Becker Muscular Dystrophy patients were utilized to study dystrophin in muscular dystrophy post-translational modifications and associated proteins.
[Genome Medicine] |
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| Investigators established a simple method to convert human pluripotent stem cells into skeletal muscle cells by using temperature-sensitive Sendai virus vector encoding myoblast determination protein, a myogenic master transcription factor.
[Journal of Cellular and Molecular Medicine] |
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| Researchers developed a robust multi-cell type 3D vessel-on-chip model based entirely on human induced pluripotent stem cells (hiPSCs). Within a fibrin hydrogel microenvironment, the hiPSC-derived vascular cells self-organized to form stable microvascular networks reproducibly, in which the vessels were lumenized and functional, responding as expected to vasoactive stimulation.
[Stem Cell Reports] |
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| Scientists determined vascular aging due to DNA damage in vascular smooth muscle cells, as achieved by smooth muscle-selective genetic removal of ERCC1 DNA repair in mice.
[Oxidative Medicine and Cellular Longevity] |
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| Researchers aimed to identify the differential expression of intracellular and exosomal miRNA in human VSMCs (hVSMCs) during replicative senescence by isolating intracellular and exosomal miRNAs from hVSMCs and subsequently subjecting them to whole-genome small RNA next-generation sequencing, bioinformatics analysis and qPCR validation.
[American Journal of Physiology-Heart and Circulatory Physiology] |
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| Scientists summarize the role of autophagy in the pathogenesis of metabolic diseases associated with or occurring in the context of aging, including insulin resistance, type 2 diabetes mellitus and sarcopenic obesity, and describes its potential as a therapeutic target.
[Nature Reviews Endocrinology] |
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| The authors discuss evidence of the role of senescent cells in the maintenance of bone homeostasis during childhood and their contribution to the pathogenesis of chronic musculoskeletal disorders, including osteoporosis, osteoarthritis, and sarcopenia.
[Bone Research] |
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| Investigators discuss major factors to consider for the development of cardiovascular tissues from stem cell derived cardiomyocytes, examine important considerations in undertaking a cardiovascular tissue engineering project, and present, interpret, and summarize some of the recent advancements in this field.
[Tissue Engineering Part B-Reviews] |
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| Satellos Bioscience, Inc., and Jesse’s Journey, Canada’s leader in Duchenne muscular dystrophy funded research, announced a research partnership and infrastructure grant to support the development of Satellos’ novel approach to treating Duchenne.
[Satellos Bioscience, Inc.] |
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| October 19 – 20, 2021
Virtual |
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| | Queen’s University Belfast – Belfast, Ireland |
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| | Sanford Burnham Prebys Medical Discovery Institute – San Diego, California, United States |
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| | European Centre Study Diabetes – Strasbourg, France |
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| | Stanford University – La Jolla, California, United States |
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| The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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