Muscle Cell News Volume 6.33 | Sep 27 2021

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    2021-09-27 | MUSCN 6.33


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.33 – 27 September, 2021
    TOP STORY

    Role of PDE10A in Vascular Smooth Muscle Cell Hyperplasia and Pathological Vascular Remodeling

    Intimal hyperplasia is a common feature of vascular remodeling disorders. Accumulation of synthetic smooth muscle cell-like cells is the main underlying cause. Researchers investigated the function of PDE10A in smooth muscle cell proliferation and intimal hyperplasia both in vitro and in vivo.
    [Cardiovascular Research]

    Abstract

    Daniel Grey investigates cell death modification as a potential therapy for immune disorders. View his profile.
    PUBLICATIONSRanked by the impact factor of the journal

    Cardiomyocyte microRNA-150 Confers Cardiac Protection and Directly Represses Proapoptotic Small Proline–Rich Protein 1A

    Scientists demonstrated that potentially novel conditional cardiomyocyte–specific miR-150 knock out in mice worsened maladaptive cardiac remodeling after myocardial infarction.
    [JCI Insight]

    Full Article

    Chronic Ethanol Exposure Induces Deleterious Changes in Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells

    Understanding biological mechanisms involved in the long-term alcohol exposure-induced cardiotoxicity is pivotal to the discovery of therapeutic strategies. Cardiomyocytes derived from human pluripotent stem cells were treated with clinically relevant doses of ethanol for various durations up to five weeks.
    [Stem Cell Reviews and Reports]

    Abstract

    LncRNA-6395 Promotes Myocardial Ischemia-Reperfusion Injury in Mice through Increasing p53 Pathway

    Scientists investigated the role of lncRNAs in myocardial ischemia-reperfusion injury. Overexpression of p53 canceled the inhibitory effects of lncRNA-6395 knockdown on cardiomyocyte apoptosis, whereas knockdown of p53 counteracted the apoptotic effects of lncRNA-6395 in cardiomyocytes.
    [Acta Pharmacologica Sinica]

    Abstract

    Histone Deacetylase HDAC4 Participates in the Pathological Process of Myocardial Ischemia-Reperfusion Injury via MEKK1/JNK Pathway by Binding to miR-206

    Investigators defined the underlying role of histone deacetylase 4 (HDAC4) and miR-206 in the pathological process of myocardial ischemia-reperfusion injury (MIRI). Up-regulation of HDAC4 and down-regulation of miR-206 occurred in rat myocardial tissues and cardiomyocytes in MIRI.
    [Cell Death Discovery]

    Full Article

    Methyltransferase-Like 3 (METTL3) Attenuates Cardiomyocyte Apoptosis with Myocardial Ischemia-Reperfusion (I/R) Injury through miR-25-3p and miR-873-5p

    Researchers showed that methyltransferase-like 3 (METTL3) was downregulated in mice ischemia-reperfusion (I/R) myocardial tissues and hypoxic/re-oxygenated (H/R) cardiomyocytes, and upregulation of METTL3 attenuated I/R and H/R-induced cell apoptosis.
    [Cell Biology International]

    Abstract

    Bioactive Compounds from Artemisia dracunculus L. Activate AMPK Signaling in Skeletal Muscle

    Scientists examined PMI-5011 activation of AMP-activated protein kinase (AMPK) signaling using murine C2C12 muscle cell culture and skeletal muscle tissue.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract

    Reduced Mitochondrial Fission and Impaired Energy Metabolism in Human Primary Skeletal Muscle Cells of Megaconial Congenital Muscular Dystrophy

    The authors investigated whether imbalanced mitochondrial dynamics affected mitochondrial function and bioenergetic efficiency in skeletal muscle cells of megaconial congenital muscular dystrophy.
    [Scientific Reports]

    Full Article

    The Actin Depolymerizing Factor, Destrin, Serves as a Negative Feedback Inhibitor of Smooth Muscle Cell Differentiation

    Scientists identified several regulatory regions that control DSTN expression including a SMC-selective enhancer that was activated by the MRTF/SRF, Notch/RBPJ, and SMAD transcription factors.
    [American Journal of Physiology-Heart and Circulatory Physiology]

    Abstract

    Increased β-Adrenergic Stimulation Augments Vascular Smooth Muscle Cell Calcification via PKA/CREB Signaling

    Researchers explored the effects of β2-adrenergic stimulation by isoproterenol on vascular smooth muscle cells (VSMC) calcification. Experiments were performed in primary human aortic VSMCs treated with isoproterenol during control or high phosphate conditions.
    [Pflugers Archiv-European Journal of Physiology]

    Abstract

    Learn how to keep your lab stockroom and cold reagents organized.
    REVIEWS

    Cellular and Molecular Modulation of Rotator Cuff Muscle Pathophysiology

    Scientists highlight the current understanding of the cellular processes that coordinate muscle regeneration, and the roles of muscle resident cells, including immune cells, fibroadipogenic progenitors, and muscle satellite cells in the pathophysiologic regulation of rotator cuff muscles following injury.
    [Journal of Orthopaedic Research]

    Abstract

    INDUSTRY AND POLICY NEWS

    Sarepta Therapeutics to Initiate Part B of MOMENTUM Study of SRP-5051 in Patients with Duchenne Muscular Dystrophy Amenable to Exon 51 Skipping Following Positive Interactions with FDA

    Sarepta Therapeutics, Inc. announced that following positive interactions with the US FDA, the Company plans to initiate Part B of the MOMENTUM study, in the fourth quarter. MOMENTUM is a global trial investigating the use of SRP-5051, the Company’s next-generation peptide-conjugated phosphorodiamidate morpholino oligomer to treat patients with Duchenne muscular dystrophy who are amenable to exon 51 skipping.
    [Sarepta Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Cell-NCI Symposium: Beyond Cancer Genomics Toward Precision Oncology

    October 4 – 6, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Assistant Professor – Pediatric Heart Disease

    Harvard Medical School – Boston, Massachusetts, United States

    Research Fellow – Cardiovascular Research

    Queen’s University Belfast – Belfast, Ireland

    Postdoctoral Associate – Cardiovascular Biology and Disease Modeling

    Sanford Burnham Prebys Medical Discovery Institute – San Diego, California, United States

    Postdoctoral Positions – Organ Cross-Talk and Metabolic Disorders

    European Centre Study Diabetes – Strasbourg, France

    Postdoctoral Research Fellow – Cardiac and Endothelial Cell Function

    Stanford University – La Jolla, California, United States

    > See All Jobs

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