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Vol. 6.35 – 18 October, 2021
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Scientists found that localized injuries, as experienced through exercise, activated a myofiber self-repair mechanism that was independent of satellite cells in mice and humans.
[Science]
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PUBLICATIONSRanked by the impact factor of the journal
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Researchers demonstrated that suppression of FGFR1 and OSMR by miR-1/133a was instrumental to prevent cardiomyocyte dedifferentiation and cell cycle entry in the adult heart.
[Science Advances]
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Due to the role of methyltransferase-like 3 (METTL3) in the physiological proliferation of cardiomyocytes, investigators aimed to determine whether METTL3 could also promote cardiomyocyte proliferation under pathological conditions and to elucidate the underlying mechanism.
[Cell Death Discovery]
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Rat primary cardiac fibroblasts were isolated and transformed into myofibroblasts using 5 ng/ml TGF-β1. Transformation of cells to myofibroblasts was confirmed with the presence of α-smooth muscle actin using Western blot.
[Scientific Reports]
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Scientists described a mechanism by which mitochondrial-localized transcriptional co-repressor p107 regulated progenitors proliferation. They showed p107 directly interacted with the mitochondrial DNA, repressing mitochondrial-encoded gene transcription.
[Nature Communications]
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Researchers showed that overexpression of miR-19b-3p in human skeletal muscle cells increased insulin signaling, glucose uptake, and maximal oxygen consumption, recapitulating the adaptive response to aerobic exercise training.
[Nature Communications]
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Investigators reported that satellite cells, the stem cell population of adult skeletal muscle necessary for its growth and regeneration, expressed uniquely the longer NF-YA isoform, majorly associated with cell differentiation.
[Nature Communications]
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Scientists used the YAC128 murine model of Huntington’s disease to examine the effects of mutant huntingtin on mitochondrial parameters related to aging in brain and skeletal muscle.
[npj Aging and Mechanisms of Disease]
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Researchers showed a new method for automated engineering of 3D human skeletal muscle models in microplates and functional compound screening to address the lack of muscle wasting disease medication.
[Communications Biology]
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Using human airway smooth muscle cells in culture as a model, the authors reported that activation of the cell surface β2-adrenoceptor, a Gs-coupled G protein-coupled receptor, evoked cAMP egress to the extracellular space.
[American Journal of Respiratory and Critical Care Medicine]
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Researchers explored the effect of acetazolamide on various calcium-handling pathways in pulmonary arterial smooth muscle cells.
[Pulmonary Circulation]
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Skeletal muscle contains a designated population of adult stem cells, called satellite cells, which are generally quiescent. The authors discuss the role and regulation of satellite cells in skeletal muscle homeostasis and regeneration.
[Nature Reviews Molecular Cell Biology]
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Scientists summarize gene-editing, immunological and induced pluripotent stem cell based therapeutics for muscular dystrophy treatment.
[European Journal of Pharmacology]
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Avidity Biosciences, Inc. announced that the US FDA has granted Fast Track Designation to its lead program, AOC 1001, for the treatment of myotonic dystrophy type 1.
[Avidity Biosciences, Inc. (BioSpace, Inc.)]
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November 1 – 3, 2021
Virtual
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Baylor College of Medicine – Houston, Texas, United States
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Radboud University Medical Centre – Nijmegen, Netherlands
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Harvard Medical School – Boston, Massachusetts, United States
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Sanford Burnham Prebys Medical Discovery Institute – San Diego, California, United States
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European Centre Study Diabetes – Strasbourg, France
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
