 | | Vol. 6.36 – 25 October, 2021 |
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| Researchers developed a platform of micron-scale cardiac muscle bundles to control biomechanics in arrays of thousands of purified, independently contracting cardiac muscle strips on two-dimensional elastomer substrates with far greater throughput than single cell methods.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists infected human induced pluripotent stem cells-derived cardiomyocytes, from healthy human subjects, with SARS-CoV-2 in the absence and presence of IL-6 and IL-1β. Infection resulted in increased numbers of multinucleated cells.
[Journal of Virology] |
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| Researchers demonstrated that fortilin sustained cardiomyocyte survival at least partly through inhibition of p53 and p53-dependent apoptosis.
[Cell Death Discovery] |
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| hsa_circ_105039 was underexpressed in the heart tissue of patients with congenital heart disease. Investigators found that hsa_circ_105039 overexpression promoted cell differentiation, viability and migration; whereas apoptosis was simultaneously repressed.
[Molecular Medicine Reports] |
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| Researchers reported that TUG1 expression was induced in mouse heart following myocardial ischemia/reperfusion injury as well as in cardiomyocytes subjected to simulated ischemia/reperfusion in vitro.
[Histology and Histopathology] |
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| The authors showed that skeletal muscle of type 2 diabetes mellitus patients exhibited degenerative remodeling of the ECM that was associated with a selective increase of a subpopulation of fibro-adipogenic progenitors (FAPs) marked by expression of THY1 (CD90)—the FAPCD90+.
[Cell Metabolism] |
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| Scientists identified a role for the muscle-specific component, Cavin4, in skeletal muscle T-tubule development by analyzing two vertebrate systems, mouse and zebrafish.
[Journal of Cell Biology] |
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| Researchers investigated the role and mechanism of circSOD2 in smooth muscle cell proliferation and neointima formation.
[Arteriosclerosis Thrombosis and Vascular Biology] |
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| The authors found a potential association between the deletion of smooth muscle 22α and deregulated nuclear receptors liver X receptors /retinoid X receptor signaling in mice.
[Cell Death & Disease] |
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| Subarachnoid hemorrhage grade, neurological scores, brain water content and brain swelling were measured to study the mechanisms of PPARβ/δ on vascular smooth muscle phenotypic transformation.
[Molecular Medicine Reports] |
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| Investigators analyze sex-related properties of the heart muscle in the context of health and disease, and discuss a framework for including sex-based differences in human cardiac tissue engineering.
[Nature Reviews Materials] |
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| CANbridge Pharmaceuticals, Inc. announced that it has entered into a research collaboration and license agreement with Scriptr Global, Inc., for the development of a gene therapy treatment targeting dystrophinopathies.
[CANbridge Pharmaceuticals, Inc.] |
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| November 6 – 7, 2021
Waterville Valley, New Hampshire, United States |
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| Sarepta Therapeutics Inc. – Columbus, Ohio, United States |
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| Baylor College of Medicine – Houston, Texas, United States |
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| Radboud University Medical Centre – Nijmegen, Netherlands |
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| Harvard Medical School – Boston, Massachusetts, United States |
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| | Sanford Burnham Prebys Medical Discovery Institute – San Diego, California, United States |
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