 | | Vol. 6.38 – 8 November, 2021 |
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| Investigators presented a simple strategy for using optical media discs with nanogrooves and other polymer-based substrates nanomolded from the discs to directly culture muscle cells to study their response to the effect of biophysical cues such as nanotopography and substrate stiffness.
[Microsystems & Nanoengineering] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that mt-clipping enables enhanced detection of cytoplasmic mRNAs, among them genes involved in heart development and pathogenesis.
[Journal of Molecular and Cellular Cardiology] |
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| Researchers established a protocol to induce human induced pluripotent stem cell differentiation into cardiomyocytes using a defined culture medium and an initial low cell density to minimize the hidden factors.
[Scientific Reports] |
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| Scientists proposed that cardiomyocyte-driven paracrine signaling, which likely involved Notch1, directed subsequent trans-differentiation of endo- and epicardial cells.
[Scientific Reports] |
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| The authors examined the immunohistochemical expression of heme oxygenase-1 in the heart samples to discuss their forensic significance to determine acute cardiac ischemia.
[Scientific Reports] |
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| Scientists examined changes in neuromuscular junction morphology, fiber cross-sectional area and fiber type, accumulation of severely atrophied myofibers, and expression of a marker of denervation in four muscles that exhibited differences in the degree of age-related atrophy.
[Experimental Gerontology] |
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| The authors demonstrated the validation and application of a novel peptide immunoaffinity liquid chromatography–tandem mass spectrometry assay.
[Gene Therapy] |
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| Researchers presented a computer vision model to classify and segmented cells containing alpha-smooth muscle actin stress fibers into two classes, with a high degree of accuracy.
[Scientific Reports] |
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| Scientists investigated the effects of PCI-34051-induced human bronchial epithelial cells-derived exosomes on human bronchial smooth muscle cells and the key exosomal miRNAs involved in this process.
[Pulmonary Pharmacology & Therapeutics] |
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| The authors highlight the key questions that need to be addressed to advance the field’s understanding of cellular senescence as a mediator of skeletal muscle aging and the potential for emerging senescent cell-targeting therapies to counter age-related deficits in muscle mass, strength, and function.
[Mechanisms of Ageing and Development] |
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| Scientists consider the impact of metabolic disorders, such as obesity and type 2 diabetes, on the regulation of calcium in skeletal muscle.
[Frontiers in Physiology] |
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| Cytokinetics, Inc. announced the completion of patient enrollment in METEORIC-HF, the second Phase III clinical trial of omecamtiv mecarbil.
[Cytokinetics, Inc. (BioSpace)] |
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| November 8 – 10, 2021
Virtual |
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| The Victor Chang Cardiac Research Institute – Darlinghurst, Australia |
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| | Saint Louis University – St. Louis, Missouri, United States |
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| | Columbia University – New York, New York, United States |
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| Sarepta Therapeutics Inc. – Columbus, Ohio, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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