 | | Vol. 6.39 – 15 November, 2021 |
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| Investigators reported that cardiac fibroblasts and mesenchymal progenitors were more hypoxic than other cardiac interstitial populations, expressed more hypoxia-inducible factor 1α (HIF-1α), and exhibited increased glycolytic metabolism.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Spatiotemporal features of contraction were analyzed in human induced pluripotent stem cell-derived cardiomyocytes monolayers attached to glass or plastic, detached, and attached to a flexible collagen hydrogel.
[Journal of Physiology] |
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| Scientists obtained data on the localization of Connexin 26 at the subcellular level. Transmission electron microscopy immunogold analyses were performed on rat heart ventricles and differentiated H9c2 cardiac cell sections as well as on differentiated H9c2 derived extracellular vesicles.
[Molecules] |
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| Investigators identified proteins that were distinctly modulated by different types of atrophy, such as the myokine CCN1/Cyr61, which regulated myofiber type switching during sarcopenia
[Cell Reports] |
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| Researchers used fibrodysplasia ossificans progressiva, a disease of progressive heterotopic ossification caused by activin receptor type-1 (ACVR1R206H) receptor mutation, to elucidate how ACVR1 affected skeletal muscle repair.
[eLife] |
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| Scientists created a single-cell transcriptomic dataset of mouse skeletal muscle by integration, consensus annotation, and analysis of 23 newly collected single cell RNA sequencing datasets and 88 publicly available single-cell and single-nucleus RNA-sequencing datasets.
[Communications Biology] |
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| Researchers analyzed the gene expression landscape on the level of the RNA transcription start sites in mouse skeletal muscles under various metabolic states to identify torpor-specific transcribed regulatory patterns.
[Communications Biology] |
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| Investigators described for the first time, voltage-dependent sodium currents in mouse corpus cavernosum smooth muscle and investigated their function.
[British Journal of Pharmacology] |
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| Researchers examined the potential stimulatory effects of U46619 and five prostanoids on the contractile activities of urinary bladder smooth muscle, focusing on the role of the TP receptor and its associated Ca2+ influx routes to understand the roles of prostanoids in the regulation of urinary bladder contractile activity.
[Life Sciences] |
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| Scientists discuss recent advancements that have led to improvement of bioprinting strategies to construct large muscle structures, boost myogenesis in vitro and in vivo, and enhance tissue integration.
[Advanced Materials] |
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| Pluristem Therapeutics Inc. announced that its multinational Phase III study, designed to determine the efficacy, safety, and tolerability of intramuscular administration of allogeneic PLX-PAD cells for the treatment of muscle injury following arthroplasty for hip fracture, is fully enrolled with 240 patients.
[Pluristem Therapeutics Inc.] |
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| November 22 – 24, 2021
Virtual |
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| Nestlé S.A. – Lausanne, Switzerland |
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| The Victor Chang Cardiac Research Institute – Darlinghurst, Australia |
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| | Saint Louis University – St. Louis, Missouri, United States |
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| | Columbia University – New York, New York, United States |
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| Sarepta Therapeutics, Inc. – Columbus, Ohio, United States |
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