| Vol. 6.40 – 22 November, 2021 |
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| Sirtuin 6 (SIRT6)-transgenic mice showed alleviated vascular calcification (VC), while vascular smooth muscle cells-specific, SIRT6 knocked down mice showed severe VC, in chronic kidney disease. [Journal of Clinical Investigation] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| The authors fabricated a unique cantilever-based device, whose surface was structured with stress-assisted micro-wrinkles. [Colloids and Surfaces B-Biointerfaces] |
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| Researchers investigated the protective effects of Metoprolol against arginine vasopressin-induced cellular senescence in cultured cardiomyocytes. [Cardiovascular Toxicology] |
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| Scientists investigated the effects of idarubicin (IDA) on the HL-1 cardiac muscle cell. Different concentrations of IDA were used at different time periods, and the Cell Counting Kit-8; 2,7-dichlorodihydrofluorescein diacetate probe method; and ELISA were used to detect the oxidative stress level. [Human & Experimental Toxicology] |
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| To investigate the preservative effects of vascular endothelial growth factor sensitization on ceramide-mediated programmed cell death of cardiomyocytes, palmitate-induced injury in H9c2 cells was established as an in vitro model. [Animal] |
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| In vitro data on C2C12 cells showed that TNF-related apoptosis-inducing ligand (TRAIL) treatment significantly increased myogenin and MyHC and other hallmarks of myogenic differentiation, which were reduced by Dr5 silencing. [Cell Death & Disease] |
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| ATP release occurred in two peaks, the first around 15 s after electrical stimulation (ES) and a second around 300 s after ES. Researchers used apyrase to hydrolyze ATP 60 s after ES, maintaining the first peak and eliminating the second peak. [Journal of General Physiology] |
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| Skeletal muscle regeneration is a highly orchestrated process that requires many steps, including proper cell division to achieve functional recovery. The role of septin-7 was investigated in this complex process. [Journal of General Physiology] |
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| Scientists showed that smooth muscle cells might be the dominant suppliers of BMP antagonists, which are niche factors essential for intestinal stem cell maintenance. [Nature Communications] |
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| Researchers defined the role of long noncoding RNA growth-arrest-specific transcript 5 (GAS5) in growth of smooth muscle cells and progression of abdominal aortic aneurysm. [Journal of Translational Medicine] |
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| Scientists review the roles and behaviors of muscle satellite cells, characteristics of new myonuclei in muscle hypertrophy, and their relevance to sarcopenia. [Experimental Cell Research] |
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| REGENXBIO, Inc. announced that the US FDA granted Orphan Drug Designation for RGX-202, a potential one-time gene therapy for the treatment of Duchenne muscular dystrophy. [REGENXBIO, Inc.] |
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| Sarepta Therapeutics Inc. – Columbus, Ohio, United States |
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| Nestlé S.A. – Lausanne, Switzerland |
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| The Victor Chang Cardiac Research Institute – Darlinghurst, Australia |
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| Saint Louis University – St. Louis, Missouri, United States |
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| Columbia University – New York, New York, United States |
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