Muscle Cell News Volume 6.40 | Nov 22 2021

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    2021-11-22 | MUSCN 6.40


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.40 – 22 November, 2021
    TOP STORY

    SIRT6 Protects Vascular Smooth Muscle Cell from Osteogenic Transdifferentiation via Runx2 in Chronic Kidney Disease

    Sirtuin 6 (SIRT6)-transgenic mice showed alleviated vascular calcification (VC), while vascular smooth muscle cells-specific, SIRT6 knocked down mice showed severe VC, in chronic kidney disease.
    [Journal of Clinical Investigation]

    AbstractFull ArticleGraphical Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Stress-Assisted Gold Micro-Wrinkles on a Polymer Cantilever for Cardiac Tissue Engineering

    The authors fabricated a unique cantilever-based device, whose surface was structured with stress-assisted micro-wrinkles.
    [Colloids and Surfaces B-Biointerfaces]

    AbstractGraphical Abstract

    Metoprolol Protects against Arginine Vasopressin-Induced Cellular Senescence in H9C2 Cardiomyocytes by Regulating the Sirt1/p53/p21 Axis

    Researchers investigated the protective effects of Metoprolol against arginine vasopressin-induced cellular senescence in cultured cardiomyocytes.
    [Cardiovascular Toxicology]

    Full Article

    Idarubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes: An In Vitro Molecular Approach

    Scientists investigated the effects of idarubicin (IDA) on the HL-1 cardiac muscle cell. Different concentrations of IDA were used at different time periods, and the Cell Counting Kit-8; 2,7-dichlorodihydrofluorescein diacetate probe method; and ELISA were used to detect the oxidative stress level.
    [Human & Experimental Toxicology]

    Abstract

    Vascular Endothelial Growth Factor Ameliorated Palmitate-Induced Cardiomyocyte Injury via JNK Pathway

    To investigate the preservative effects of vascular endothelial growth factor sensitization on ceramide-mediated programmed cell death of cardiomyocytes, palmitate-induced injury in H9c2 cells was established as an in vitro model.
    [Animal]

    Full Article

    TRAIL/DR5 Pathway Promotes AKT Phosphorylation, Skeletal Muscle Differentiation, and Glucose Uptake

    In vitro data on C2C12 cells showed that TNF-related apoptosis-inducing ligand (TRAIL) treatment significantly increased myogenin and MyHC and other hallmarks of myogenic differentiation, which were reduced by Dr5 silencing.
    [Cell Death & Disease]

    Full Article

    On the Molecular Mechanism of Excitation–Transcription Coupling in Skeletal Muscle: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle

    ATP release occurred in two peaks, the first around 15 s after electrical stimulation (ES) and a second around 300 s after ES. Researchers used apyrase to hydrolyze ATP 60 s after ES, maintaining the first peak and eliminating the second peak.
    [Journal of General Physiology]

    Abstract

    Septin-7 Is Indispensable in Skeletal Muscle Regeneration: Calcium Signaling and Excitation–Contraction in Cardiac, Skeletal and Smooth Muscle

    Skeletal muscle regeneration is a highly orchestrated process that requires many steps, including proper cell division to achieve functional recovery. The role of septin-7 was investigated in this complex process.
    [Journal of General Physiology]

    Abstract

    Smooth Muscle-Specific MMP17 (MT4-MMP) Regulates the Intestinal Stem Cell Niche and Regeneration after Damage

    Scientists showed that smooth muscle cells might be the dominant suppliers of BMP antagonists, which are niche factors essential for intestinal stem cell maintenance.
    [Nature Communications]

    Full Article

    Knockdown of Long Noncoding RNA GAS5 Reduces Vascular Smooth Muscle Cell Apoptosis by Inactivating EZH2-Mediated RIG-I Signaling Pathway in Abdominal Aortic Aneurysm

    Researchers defined the role of long noncoding RNA growth-arrest-specific transcript 5 (GAS5) in growth of smooth muscle cells and progression of abdominal aortic aneurysm.
    [Journal of Translational Medicine]

    Full Article

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    REVIEWS

    Regulation of Muscle Hypertrophy: Involvement of the Akt-Independent Pathway and Satellite Cells in Muscle Hypertrophy

    Scientists review the roles and behaviors of muscle satellite cells, characteristics of new myonuclei in muscle hypertrophy, and their relevance to sarcopenia.
    [Experimental Cell Research]

    Abstract

    INDUSTRY AND POLICY NEWS

    REGENXBIO Announces Orphan Drug Designation Granted to RGX-202, a Novel Gene Therapy Candidate for the Treatment of Duchenne Muscular Dystrophy

    REGENXBIO, Inc. announced that the US FDA granted Orphan Drug Designation for RGX-202, a potential one-time gene therapy for the treatment of Duchenne muscular dystrophy.
    [REGENXBIO, Inc.]

    Press Release

    FEATURED EVENT

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    December 2, 2021
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    JOB OPPORTUNITIES

    Research Associate I : Histology & Morphometrics

    Sarepta Therapeutics Inc. – Columbus, Ohio, United States

    PhD – Translational Skeletal Muscle Stem Cell biology

    Nestl̩ S.A. РLausanne, Switzerland

    Postdoctoral Scientist – Development and Regeneration

    The Victor Chang Cardiac Research Institute – Darlinghurst, Australia

    Vice President – Medical Affairs and Dean of the School of Medicine

    Saint Louis University – St. Louis, Missouri, United States

    Scientist – iPSC Derived Cardiac Tissues

    Columbia University – New York, New York, United States

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