Muscle Cell News Volume 6.42 | Dec 6 2021

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    2021-12-06 | MUSCN 6.42


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.42 – 6 December, 2021
    TOP STORY

    LncRNA HSPA7 in Human Atherosclerotic Plaques Sponges miR-223 and Promotes the Proinflammatory Vascular Smooth Muscle Cell Transition

    Scientists identified and functionally validated a lncRNA using human atherosclerotic plaques. Human aortic samples were obtained from patients who underwent aortic surgery, and tissues were classified according to atherosclerotic plaques.
    [Experimental and Molecular Medicine]

    Full Article

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    Dapagliflozin Attenuates Pressure Overload-Induced Myocardial Remodeling in Mice via Activating SIRT1 and Inhibiting Endoplasmic Reticulum Stress

    In vitro, researchers found that dapagliflozin (DAPA) inhibited the expression of cleaved caspase 3, Bax, C/EBP homologous protein, and glucose-regulated protein78 and upregulated the cardiomyoprotective protein Bcl-2 in angiotensin II-treated cardiomyocytes.
    [Acta Pharmacologica Sinica]

    Abstract

    AIFM1, Negatively Regulated by miR-145-5p, Aggravates Hypoxia-Induced Cardiomyocyte Injury

    Scientists probed into the role and the underlying regulatory mechanism of apoptosis-inducing factor mitochondria associated 1 (AIFM1) in myocardial injury.
    [Biomedical Journal]

    Full Article

    TAZ Exhibits Phase Separation Properties and Interacts with Smad7 and β-Catenin to Repress Skeletal Myogenesis

    The authors assessed the potential role of WW domain-containing transcription regulator protein 1 (TAZ) on theSmad7/β-catenin complex in muscle cells. They documented functional interactions between Smad7, TAZ and β-catenin in myogenic cells.
    [Journal of Cell Science]

    Abstract

    Nano-Sized Graphene Oxide Coated Nanopillars on Microgroove Polymer Arrays That Enhance Skeletal Muscle Cell Differentiation

    Scientists reported a nano-sized graphene oxide-modified nanopillar on microgroove hybrid polymer array that effectively controlled skeletal muscle cell differentiation.
    [Nano Convergence]

    Full Article

    Angptl2 Gene Knockdown Is Critical for Abolishing Angiotensin II-Induced Vascular Smooth Muscle Cell Proliferation and Migration

    Wistar-Kyoto rats and spontaneously hypertensive rats were used to detect the expression of Angptl2. Angiotensin II stimulated vascular smooth muscle cells to mimic hypertension in vitro.
    [Biochemistry and Cell Biology]

    Abstract

    A Machine Learning Pipeline Revealing Heterogeneous Responses to Drug Perturbations on Vascular Smooth Muscle Cell Spheroid Morphology and Formation

    To identify the heterogeneous responses of drug treatments, scientists created an in vitro experimental model system using vascular smooth muscle cell spheroids and developed a machine learning-based computational method called HETEROID.
    [Scientific Reports]

    Full Article

    Protective Effects of Progesterone on Pulmonary Artery Smooth Muscle Cells Stimulated with Interleukin 6 via Blocking the Shuttling and Transcriptional Function of STAT3

    Investigators revealed that interleukin-6 (IL-6) promoted the proliferation of pulmonary artery smooth muscle cells, but progesterone could reverse the adverse effect of IL-6.
    [International Immunopharmacology]

    Abstract

    miR-222-5p Promotes Dysfunction of Human Vascular Smooth Muscle Cells by Targeting RB1

    The viability and migration of vascular smooth muscle cells were detected by Cell Counting Kit-8 and Transwell assays. Protein levels of proliferation and migration-related factors were evaluated by western blotting.
    [Environmental Toxicology]

    Abstract

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    REVIEWS

    From Quiescence to Repair: C/EBPβ as a Regulator of Muscle Stem Cell Function in Health and Disease

    Scientists describe a role for CCAAT/enhancer binding protein beta (C/EBPβ) in muscle stem cells and propose a functional intersection between C/EBPβ and NF-kB action in the regulation of cancer cachexia.
    [FEBS Journal]

    Abstract

    Long Noncoding RNAs Involved in Cardiomyocyte Apoptosis Triggered by Different Stressors

    Understanding the molecular mechanisms that regulate cardiomyocyte apoptosis is of great significance for the prevention and treatment of cardiovascular diseases.
    [Journal of Cardiovascular Translational Research]

    Full ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Catalyst Pharmaceuticals Announces DyDo Pharma Initiation of a Phase III Study for FIRDAPSE® (Amifampridine) in Japan

    Catalyst Pharmaceuticals, Inc. announced that its collaboration partner DyDo Pharma has initiated a Phase III registrational study in Japan to evaluate the efficacy and safety of Catalyst’s FIRDAPSE® 10 mg tablets for the treatment of Lambert-Eaton myasthenic syndrome.
    [Catalyst Pharmaceuticals, Inc. (GlobenewsWire, Inc.)]

    Press Release

    FEATURED EVENT

    AACR: Cancer Metastasis

    January 9 – 12, 2022
    Portland, Oregon, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Scientist – Cardiovascular Disease

    Columbia University – New York, New York, United States

    Postdoctoral Position – Cardiovascular, Respiratory and Metabolic Research

    University of California, Los Angeles – Los Angeles, California, United States

    Research Associate I : Histology & Morphometrics

    Sarepta Therapeutics Inc. – Columbus, Ohio, United States

    Postdoctoral Scientist – Development and Regeneration

    The Victor Chang Cardiac Research Institute – Darlinghurst, Australia

    Vice President – Medical Affairs and Dean of the School of Medicine

    Saint Louis University – St. Louis, Missouri, United States

    > See All Jobs

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