Muscle Cell News Volume 6.43 | Dec 13 2021

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    2021-12-13 | MUSCN 6.43


    Muscle Cell News by STEMCELL Technologies
    Vol. 6.43 – 13 December, 2021
    TOP STORY

    Human miRNA miR-675 Inhibits DUX4 Expression and May Be Exploited as a Potential Treatment for Facioscapulohumeral Muscular Dystrophy

    Researchers reported a strategy to direct RNA interference against DUX4 using the natural microRNA miR-675, which was derived from the lncRNA H19.
    [Nature Communications]

    Full Article

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    Stage-Specific Regulation of DNA Methylation by TET Enzymes during Human Cardiac Differentiation

    Scientists characterized stage-specific methylation dynamics and the function of ten-eleven translocation (TETs) during human cardiomyocyte differentiation.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Hippo Pathway Effector Tead1 Induces Cardiac Fibroblast to Cardiomyocyte Reprogramming

    The conversion of fibroblasts into induced cardiomyocytes might regenerate myocardial tissue from cardiac scar through in situ cell transdifferentiation. Investigators explored the leveraging of Hippo pathway intermediates to enhance induced cardiomyocyte generation.
    [Journal of the American Heart Association]

    Full Article

    IRF2 Contributes to Myocardial Infarction via Regulation of GSDMD Induced Pyroptosis

    The authors investigated the involvement of Interferon regulatory factor (IRF) 2 in myocardial infarction and the underlying mechanism of IRF2 in pyroptosis.
    [Molecular Medicine Reports]

    Abstract

    Low-Level Laser Prevents Doxorubicin-Induced Skeletal Muscle Atrophy by Modulating AMPK/SIRT1/PCG-1α-Mediated Mitochondrial Function, Apoptosis and Up-Regulation of Pro-Inflammatory Responses

    Researchers tested whether low-level laser irradiation protected skeletal muscles against Dox-induced muscle wasting by using both animal and C2C12 myoblast cell models.
    [Cell & Bioscience]

    Full Article

    Taurine Stimulates Protein Synthesis and Proliferation of C2C12 Myoblast Cells through the PI3K-ARID4B-mTOR Pathway

    Scientists investigated the role and underlying molecular mechanism of Tau on protein synthesis and proliferation of C2C12 myoblast cells.
    [British Journal of Nutrition]

    Abstract

    Polygonatum sibiricum Polysaccharides (PSP) Improve the Palmitic Acid (PA)-Induced Inhibition of Survival, Inflammation, and Glucose Uptake in Skeletal Muscle Cells

    The underlying molecular mechanisms of PSP in improving insulin resistance (IR) in skeletal muscle remain unclear. PA induced an IR model in L6 myotubes. After treatment, cell proliferation was measured using the CCK8.
    [Bioengineered]

    Full Article

    Endothelial Cell–Derived Exosomal circHIPK3 Promotes the Proliferation of Vascular Smooth Muscle Cells Induced by High Glucose via the miR-106a-5p/Foxo1/Vcam1 Pathway

    The authors explored the roles and underlying mechanism of exosomes derived from endothelial cells (ECs) in the crosstalk between ECs and vascular smooth muscle cells.
    [Aging]

    Full Article

    Nuclear Paraspeckle Assembly Transcript 1 Enhances Hydrogen Peroxide-Induced Human Vascular Smooth Muscle Cell Injury by Regulating miR-30d-5p/a Disintegrin and Metalloprotease 10

    The expression of nuclear paraspeckle assembly transcript 1, miR-30d-5p and A disintegrin and metalloprotease 10 was measured by qRT-PCR and western blot. Functional experiments were conducted by using a CCK-8 assay, EDU assay, flow cytometry, western blot, ELISA, and commercial kits.
    [Circulation Journal]

    Abstract

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    REVIEWS

    Fibro-Adipogenic Progenitors in Skeletal Muscle Homeostasis, Regeneration and Diseases

    Scientists summarize the current knowledge on fibro-adipogenic progenitors cell characteristics, heterogeneity and the cellular crosstalk during skeletal muscle homeostasis and regeneration.
    [Open Biology]

    Full Article

    Therapeutic Approaches to Preserve the Musculature in Duchenne Muscular Dystrophy: The Importance of the Secondary Therapies

    The authors outline the most interesting and recent studies addressing the secondary outcomes of duchenne muscular dystrophy and how to better deliver the therapeutic agents.
    [Experimental Cell Research]

    Abstract

    INDUSTRY AND POLICY NEWS

    electroCore Announces New Patent for Stroke and TIA Treatment

    electroCore, Inc. announced that the United States Patent and Trademark Office has issued US Patent No. 11,191,953 to the company, relating to the treatment of stroke symptoms. The newly issued patent is related to methods for treating the acute symptoms of stroke or transient ischemic attack (TIA).
    [electroCore, Inc.]

    Press Release

    FEATURED EVENT

    Immunometabolism at the Crossroads of Obesity and Cancer

    January 16 – 20, 2022
    Banff, Alberta, Canada

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    JOB OPPORTUNITIES

    Postdoctoral or Master’s Researcher – Aging

    Buck Institute for Research on Aging – Novato, California, United States

    Postdoctoral Research Scientist – Cardiovascular Disease

    Columbia University – New York, New York, United States

    Postdoctoral Position – Cardiovascular, Respiratory and Metabolic Research

    University of California, Los Angeles – Los Angeles, California, United States

    Research Associate I – Histology & Morphometrics

    Sarepta Therapeutics Inc. – Columbus, Ohio, United States

    Postdoctoral Scientist – Development and Regeneration

    The Victor Chang Cardiac Research Institute – Darlinghurst, Australia

    > See All Jobs

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