Muscle Cell News Volume 7.00 | Jan 10 2022

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    2022-01-10 | MUSCN 7.00


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.00 – 10 January, 2022
    TOP STORY

    Skeletal Muscle Derived Musclin Protects the Heart during Pathological Overload

    Scientists investigated whether the dysregulation of myokine expression from wasting skeletal muscle exaggerated heart failure.
    [Nature Communications]

    Full Article

    New human primary cancer-sourced blood products, immune cell subsets, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    Aligned Human Induced Pluripotent Stem Cell-Derived Cardiac Tissue Improves Contractile Properties through Promoting Unidirectional and Synchronous Cardiomyocyte Contraction

    The authors fabricated aligned human cardiac tissue using a micro-processed fibrin gel with inverted V-shaped ridges and elucidated the effect of alignment control on contractile properties.
    [Biomaterials]

    Abstract

    CRISPR/Cas9 Editing of Directly Reprogrammed Myogenic Progenitors Restores Dystrophin Expression in a Mouse Model of Muscular Dystrophy

    Scientists reported on reprogramming of fibroblasts from two Duchenne muscular dystrophy mouse models into induced myogenic progenitor cells by MyoD overexpression in concert with small molecule treatment.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Comparative Proteomic Analysis of Nuclear and Cytoplasmic Compartments in Human Cardiac Progenitor Cells

    Two proteins significantly upregulated in the human cardiac progenitor cells (hCPC) nuclear compartment, IL1A and IMP3, showed a parallel increase in mRNA expression in hCPC versus human mesenchymal stem cells, and were studied further.
    [Scientific Reports]

    Full Article

    NLK Is Required for Ras/ERK/SRF/ELK Signaling to Tune Skeletal Muscle Development by Phosphorylating SRF and Antagonizing the SRF/MKL Pathway

    Researchers showed that Nemo-like kinase (NLK) was required for the promotion of serum response factor (SRF)/ELK signaling in human and mouse cells.
    [Cell Death Discovery]

    Full Article

    Endothelial Cells Are an Important Source of BDNF in Rat Skeletal Muscle

    Scientists provided a comprehensive analysis of brain-derived neurotrophic factor (BDNF) localization in rat skeletal muscle.
    [Scientific Reports]

    Full Article

    Dysregulation of Interaction between LOXhigh Fibroblast and Smooth Muscle Cells Contributes to the Pathogenesis of Aortic Dissection

    By use of single-cell RNA-sequencing and multi-color staining, scientists delineated the cellular composition and spatial characterization of human aorta with or without aortic dissection.
    [Theranostics]

    Full ArticleGraphical Abstract

    Epigallocatechin Gallate Facilitates Extracellular Elastin Fiber Formation in Induced Pluripotent Stem Cell Derived Vascular Smooth Muscle Cells for Tissue Engineering

    Researchers established the ability of the polyphenol compound epigallocatechin gallate, a principal component of green tea, to facilitate the extracellular formation of elastin fibers in vascular smooth muscle cells derived from human induced pluripotent stem cells.
    [Journal of Molecular and Cellular Cardiology]

    AbstractGraphical Abstract

    Endothelial-Derived Extracellular microRNA-92a Promotes Arterial Stiffness by Regulating Phenotype Changes of Vascular Smooth Muscle Cells

    Scientists investigated the role of endothelial-derived extracellular microRNA-92a in promoting arterial stiffness by regulating endothelial cell–vascular smooth muscle cell communication.
    [Scientific Reports]

    Full Article

    Inhibitors of the MAPK/ NF-κB Pathway Attenuate the Upregulation of the ETB Receptor Mediated by High Glucose in Vascular Smooth Muscle Cells

    Researchers investigated the mechanism of high glucose-induced endothelin type B (ETB) receptors in vascular smooth muscle cell.
    [Peptides]

    AbstractGraphical Abstract

    Facts above claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    REVIEWS

    Transforming Growth Factor-β in Myocardial Disease

    The authors summarize the current evidence on the role of transforming growth factor-β signaling in myocardial diseases, focusing on cellular targets and molecular mechanisms, and discuss challenges and opportunities for therapeutic translation.
    [Nature Reviews Cardiology]

    Abstract

    Skeletal Muscle Alterations in Patients with Acute COVID-19 and Post-acute Sequelae of COVID-19

    Scientists discuss cellular and molecular pathways that are affected by acute Covid-19 and post-acute sequelae of Covid-19 and consider these in regard to skeletal muscle involvement in other conditions, such as acute respiratory distress syndrome, critical illness myopathy, and post-viral fatigue syndrome.
    [Journal of Cachexia Sarcopenia and Muscle]

    Full Article

    INDUSTRY AND POLICY NEWS

    LianBio Announces First Patient Dosed in Registrational Phase III EXPLORER-CN Trial of Mavacamten in Chinese Patients with Obstructive Hypertrophic Cardiomyopathy

    LianBio announced the first patient has been dosed in the Phase III EXPLORER-CN clinical trial of mavacamten in Chinese patients with symptomatic obstructive hypertrophic cardiomyopathy.
    [LianBio]

    Press Release

    FEATURED EVENT

    Lorne Cancer 2022

    February 10 – 12, 2022
    Lorne, Victoria, Australia

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Molecular Medicine

    Ume̴ University РUme̴, Sweden

    Faculty Position – Molecular Therapeutics

    Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States

    Postdoctoral or Master’s Researcher – Aging

    Buck Institute for Research on Aging – Novato, California, United States

    Research Associate – Cardiovascular Disease Modeling

    Cedars-Sinai Regenerative Medicine Institute – Los Angeles, California, United States

    Postdoctoral Position – Cardiovascular, Respiratory and Metabolic Research

    University of California, Los Angeles – Los Angeles, California, United States

    > See All Jobs

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