 | | Vol. 7.01 – 17 January, 2022 |
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| Investigators showed that MyoD functioned as a “genome organizer” that specified 3D genome architecture unique to muscle cell development, and that H3K27ac was insufficient for the establishment of MyoD-induced chromatin loops in muscle cells.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers measured the levels of inflammation, fibrosis, apoptosis, and necrosis in endomyocardial biopsies and sera of nonischemic parvovirus(PV) B19-positive and PVB19-negative dilated cardiomyopathy patients.
[Advances in Experimental Medicine and Biology] |
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| A20 was underexpressed and miR-1a-3p was overexpressed in the myocardium of viral myocarditis mice as well as in Coxsackie virus B3-infected cardiomyocytes.
[BMC Cardiovascular Disorders] |
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| To elucidate the underlying cellular and molecular mechanisms of metabolic reprogramming, researchers chronically treated wild-type mice and several newly developed mutant mouse strains with clenbuterol, a selective β2-adrenergic receptor agonist.
[Nature Communications] |
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| Scientists demonstrated that while two resident stem cell populations, muscle stem cells (MuSCs) and fibro/adipogenic progenitors, had similar proliferation rates after injury, the differentiation potential of mutant MuSCs was compromised.
[NPJ Regenerative Medicine] |
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| Researchers performed metabolic profiling of the C2C12 myoblasts and myotubes in serum-free mediums and compared it with conventional serum supplementation culture.
[Scientific Reports] |
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| Researchers discovered the possible role and mechanism of long coding RNA X-inactivate specific transcript (XIST) in oxidized low-density lipoprotein (ox-LDL) – stimulated vascular smooth muscle cells, which could further help evalute its possible a role in the progression of atherosclerosis.
[Oxidative Medicine and Cellular Longevity] |
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| Evaluation of 2-benzyllawsone against vascular hyporeactivity, hypotension, and sepsis-related inflammation and infection was carried out in the cecal ligation and puncture model in Swiss albino mice and aortic smooth muscle cells in vitro.
[European Journal of Pharmacology] |
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| In endothelial cells and vascular smooth muscle cells, stimulation with high glucose, TNFα or LPS induced a significant upregulation of endogenous G-protein coupled receptor 5B of family C (GPRC5B) mRNA and protein levels.
[Biochemical and Biophysical Research Communications] |
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| Scientists summarize recent advances in tissue transglutaminase and discuss its role and mechanisms in the progression of various cardiovascular disease and its potential as a diagnostic and therapeutic target.
[Pharmacological Research] |
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| Sarepta Therapeutics, Inc. announced topline results from Part II of Study SRP-9001-102, an ongoing, randomized, double-blind, placebo-controlled clinical trial to evaluate the safety, efficacy and tolerability of a single dose of SRP-9001 in 41 patients with Duchenne muscular dystrophy.
[Sarepta Therapeutics, Inc.] |
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| Ksilink – Strasbourg, France |
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| Umeå University – Umeå, Sweden |
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| Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States |
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| RWTH Aachen Medical School – Aachen, Germany |
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| | Cedars-Sinai Regenerative Medicine Institute – Los Angeles, California, United States |
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