Muscle Cell News Volume 7.04 | Feb 7 2022

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    2022-02-07 | MUSCN 7.04


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.04 – 7 February, 2022
    TOP STORY

    Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival

    Scientists investigated the roles and mechanisms of the action of mammalian Ste20-like kinases (MST) 1 and MST2 in pulmonary arterial hypertension.
    [Circulation Research]

    Abstract

    Explore tools and resources for your return to the lab
    PUBLICATIONSRanked by the impact factor of the journal

    Apelin-13/APJ Induces Cardiomyocyte Hypertrophy by Activating the Pannexin-1/P2X7 Axis and FAM134B-Dependent Reticulophagy

    The authors observed that apelin-13-induced cardiomyocyte hypertrophy by activating FAM134B-dependent reticulophagy via the Pannexin-1/P2X7 signal pathway.
    [Journal of Cellular Physiology]

    Abstract

    Targeting ACSL1 Promotes Cardiomyocyte Proliferation and Cardiac Regeneration

    Investigators identified the role of acyl coA synthase long chain family member 1 (ACSL1) in the regeneration of cardiomyocytes.
    [Life Sciences]

    Abstract

    Cardiac Fibroblasts Secrete Exosome microRNA to Suppress Cardiomyocyte Pyroptosis in Myocardial Ischemia/Reperfusion Injury

    Scientists showed that cardiac fibroblasts protected cardiomyocytes against myocardial ischemia/reperfusion-induced injury through suppression of pyroptosis.
    [Molecular and Cellular Biochemistry]

    Full Article

    The Effect of Hypoxia on Myogenic Differentiation and Multipotency of the Skeletal Muscle-Derived Stem Cells in Mice

    Researchers examined the effect of low oxygen tension on myogenic differentiation protocols of the myoblasts cell line C2C12.
    [Stem Cell Research & Therapy]

    Full Article

    Construction of Adenovirus Vector Expressing Duck Sclerostin and Its Induction Effect on Myogenic Proliferation and Differentiation In Vitro

    Scientists used a bird model to illustrate the potential roles of sclerostin (SOST) on duck myoblasts to verify the hypothesis that SOST might play functions in coordinating the development of bones and muscles.
    [Molecular Biology Reports]

    Abstract

    Interleukin-4-Induced FABP4 Promotes Lipogenesis in Human Skeletal Muscle Cells by Activating the PPAR γ Signaling Pathway

    The authors investigated the effect of fatty acid binding protein 4 (FABP4) on lipogenesis in human skeletal muscle cells stimulated by interleukin-4 and explored the mechanistic basis.
    [Cell Biochemistry and Biophysics]

    Abstract

    Old Blood from Heterochronic Parabionts Accelerates Vascular Aging in Young Mice: Transcriptomic Signature of Pathologic Smooth Muscle Remodeling

    Researchers reanalyzed existing RNA-seq data, comparing the transcriptome in the aorta arch samples isolated from isochronic parabiont aged C57BL/6 mice.
    [GeroScience]

    Abstract

    Lipopolysaccharide Acting via Toll-Like Receptor 4 Transactivates the TGF-β Receptor in Vascular Smooth Muscle Cells

    The in vitro model used human aortic vascular smooth muscle cells to assess the implications of toll-like receptor 4 transactivation of the transforming growth factor-β receptor 1 in vascular pathophysiology.
    [Cellular and Molecular Life Sciences]

    Full Article

    Explore Antibodies for Epithelial Cell Markers
    REVIEWS

    The Importance of Mitochondrial Quality Control for Maintaining Skeletal Muscle Function across Healthspan

    Knowledge regarding the role and regulation of mitochondrial quality control in skeletal muscle and the influence of aging in this process have rapidly advanced in the last decade.
    [American Journal of Physiology-Cell Physiology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Cytokinetics Announces FDA Acceptance of New Drug Application for Omecamtiv Mecarbil for the Treatment of Heart Failure with Reduced Ejection Fraction

    Cytokinetics, Incorporated announced that the US FDA has accepted and filed the company’s New Drug Application for omecamtiv mecarbil, an investigational, selective, small molecule cardiac myosin activator, for the treatment of heart failure with reduced ejection fraction.
    [Cytokinetics, Inc.]

    Press Release

    FEATURED EVENT

    Danish Stem Cell Society (DASCS) 2022

    Sep 19 – 20 2022
    Vejle, Denmark

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    JOB OPPORTUNITIES

    Professor – Skeletal Muscle Metabolism and Disorder

    KU Leuven – Leuven, Belgium

    Research Scientist – Cardiobiology

    Ksilink – Strasbourg, France

    Postdoctoral Fellow – Molecular Medicine

    Ume̴ University РUme̴, Sweden

    Faculty Position – Molecular Therapeutics

    Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States

    Scientist – Epigenetics of Aging

    RWTH Aachen Medical School – Aachen, Germany

    > See All Jobs

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