Muscle Cell News Volume 7.05 | Feb 14 2022

May 12, 2022

2022-02-14 | MUSCN 7.05

Muscle Cell News by STEMCELL Technologies

Vol. 7.05 – 14 February, 2022

TOP STORY

Human Pancreatic Tumor Organoid-Derived Factors Enhance Myogenic Differentiation

Scientists investigated the effect of pancreatic tumor organoid-derived factors on processes that determined skeletal muscle mass, including the regulation of muscle protein turnover and myogenesis.
[Journal of Cachexia Sarcopenia and Muscle]

Full Article

Request your free copy of the 'Cell-Reprogramming Technology and Neuroscience' Wallchart

PUBLICATIONSRanked by the impact factor of the journal

CARDIAC MUSCLE CELLS

A Human Cell Atlas of the Pressure-Induced Hypertrophic Heart

Researchers presented the transcriptional response of human cardiomyocytes to pressure overload caused by aortic valve stenosis and described major alterations in cardiac cellular crosstalk.
[Nature Cardiovascular Research]

Full Article

PHLPP1 Deficiency Ameliorates Cardiomyocyte Death and Cardiac Dysfunction through Inhibiting Mcl-1 Degradation

Investigators found that pleckstrin homology domain leucine-rich repeat protein phosphatase1 (PHLPP1) deficiency enhanced Thr163 phosphorylation of myeloid cell leukemia sequence (Mcl-1), inhibited Mcl-1 degradation and maintained Mcl-1 protein expression level in myocardium and cardiomyocytes.
[Cellular Signalling]

Abstract

SKELETAL MUSCLE CELLS

ERK3-MK5 Signaling Regulates Myogenic Differentiation and Muscle Regeneration by Promoting FoxO3 Degradation

Researchers showed that genetic inactivation of extracellular signal-regulated kinase 3 (ERK3) impaired postnatal skeletal muscle growth and adult muscle regeneration after injury.
[Journal of Cellular Physiology]

Abstract

Widespread Mislocalization of FUS Is Associated with Mitochondrial Abnormalities in Skeletal Muscle in Amyotrophic Lateral Sclerosis with FUS Mutations

Scientists investigated fused in sarcoma (FUS) protein distribution in skeletal muscle fibers in amyotrophic lateral sclerosis-FUS.
[Journal of Neuropathology and Experimental Neurology]

Abstract

SMOOTH MUSCLE CELLS

STIM1-Dependent Peripheral Coupling Governs the Contractility of Vascular Smooth Muscle Cells

The authors found that the number and size of sarcoplasmic reticulum (SR)-plasma membrane interacting sites were decreased, and SR-dependent Ca²⁺ signaling processes were disrupted in freshly isolated cerebral artery SMCs from tamoxifen-inducible, SMC-specific STIM1-knockout mice.
[eLife]

Abstract

Myocardin/microRNA-30a/Beclin1 Signaling Controls the Phenotypic Modulation of Vascular Smooth Muscle Cells by Regulating Autophagy

Knockdown of myocardin (MYOCD) in human aortic vascular smooth muscle cells (VSMCs) triggered autophagy and diminished the expression of SMC contractile proteins. Inhibition of autophagy in MYOCD-knockdown cells restored the expression of contractile proteins.
[Cell Death & Disease]

Full Article

BRD4770 Functions as a Novel Ferroptosis Inhibitor to Protect against Aortic Dissection

Scientists found that the iron level, ferroptosis-related molecules TFR, HOMX1, ferritin and the lipid peroxidation product 4-hydroxynonenal were increased in the aorta of aortic dissection.
[Pharmacological Research]

Full Article Graphical Abstract

LncPTSR Triggers Vascular Remodeling in Pulmonary Hypertension by Regulating [Ca²⁺]i in Pulmonary Arterial Smooth Muscle Cells

A long non-coding RNA attenuated by platelet-derived growth factor BB was identified and its functional roles were investigated in vitro and in vivo.
[American Journal of Respiratory Cell and Molecular Biology]

Abstract

BRCC36 Prevents Vascular Calcification in Chronic Kidney Disease through the β-Catenin Signaling Pathway

Researchers established an ^{in vitro} vascular calcification model of vascular smooth muscle cells and an adenine-induced chronic kidney disease mouse model.
[Experimental Cell Research]

Abstract

Virtual Conference Exhibition: Pluripotent Stem Cells

REVIEWS

Muscle Stem Cell Adaptations to Cellular and Environmental Stress

Scientists proposed a cellular stress test model whereby the prolonged state of quiescence and the microenvironment serve as selective pressures to maintain muscle stem cell fitness, to safeguard the lifelong regeneration of the muscle.
[Skeletal Muscle]

Full Article

INDUSTRY AND POLICY NEWS

Alkem Licenses Technology from Harvard University, Aiming to Treat Ischemic Injury and Vascular Diseases

Alkem Laboratories Limited has signed a license agreement with Harvard University’s Office of Technology Development enabling Alkem to develop and commercialize a novel technology that may help meet the dire need for effective treatment of diabetic neuropathy, and other injuries caused by vascular disease.
[Alkem Laboratories Limited (GlobeNewswire, Inc.)]

Press Release

enGene Announces Positive Preliminary Phase I/II Data with EG-70 in BCG-Unresponsive Non-Muscle Invasive Bladder Cancer

enGene, Inc. announced positive results from its LEGEND study, a first-in-human Phase I/II clinical trial of EG-70 for the treatment of high-grade non-muscle Invasive bladder cancer in patients with carcinoma in situ that are BCG-unresponsive.
[enGene Inc. (PR Newswire, Inc.)]

Press Release

FEATURED EVENT

Human Pancreatic Tumor Organoid-Derived Factors Enhance Myogenic Differentiation

A Human Cell Atlas of the Pressure-Induced Hypertrophic Heart

PHLPP1 Deficiency Ameliorates Cardiomyocyte Death and Cardiac Dysfunction through Inhibiting Mcl-1 Degradation

ERK3-MK5 Signaling Regulates Myogenic Differentiation and Muscle Regeneration by Promoting FoxO3 Degradation

Widespread Mislocalization of FUS Is Associated with Mitochondrial Abnormalities in Skeletal Muscle in Amyotrophic Lateral Sclerosis with FUS Mutations

STIM1-Dependent Peripheral Coupling Governs the Contractility of Vascular Smooth Muscle Cells

Myocardin/microRNA-30a/Beclin1 Signaling Controls the Phenotypic Modulation of Vascular Smooth Muscle Cells by Regulating Autophagy

BRD4770 Functions as a Novel Ferroptosis Inhibitor to Protect against Aortic Dissection

LncPTSR Triggers Vascular Remodeling in Pulmonary Hypertension by Regulating [Ca²⁺]i in Pulmonary Arterial Smooth Muscle Cells

BRCC36 Prevents Vascular Calcification in Chronic Kidney Disease through the β-Catenin Signaling Pathway

Muscle Stem Cell Adaptations to Cellular and Environmental Stress

Alkem Licenses Technology from Harvard University, Aiming to Treat Ischemic Injury and Vascular Diseases

enGene Announces Positive Preliminary Phase I/II Data with EG-70 in BCG-Unresponsive Non-Muscle Invasive Bladder Cancer

The 37^th Annual Congress of the European Association of Urology – Amsterdam

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Postdoctoral Fellow – Neurodegeneration

Professor – Skeletal Muscle Metabolism and Disorder

Research Scientist – Cardiobiology

Postdoctoral Fellow – Molecular Medicine

Faculty Position – Molecular Therapeutics

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