Muscle Cell News Volume 7.06 | Feb 28 2022

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    2022-02-28 | MUSCN 7.06


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.06 – 28 February, 2022
    TOP STORY

    A Fast Myosin Super Enhancer Dictates Muscle Fiber Phenotype through Competitive Interactions with Myosin Genes

    Researchers identified by snATAC-seq a 42 kb super-enhancer at the locus regrouping the fast Myosin genes.
    [Nature Communications]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Direct Cardio-Protection of Dapagliflozin against Obesity-Related Cardiomyopathy via NHE1/MAPK Signaling

    Scientists investigated the protective effect of Dapagliflozin against cardiomyopathy caused by high fat diet-induced obesity in vitro and in vivo.
    [Acta Pharmacologica Sinica]

    Abstract

    MBNL1 Drives Dynamic Transitions between Fibroblasts and Myofibroblasts in Cardiac Wound Healing

    Investigators investigated whether tactical control of muscle blind-like 1 (MBNL1) activity could alter myofibroblast activity and fibrotic outcomes.
    [Bmb Reports]

    AbstractGraphical Abstract

    Anti-Diabetic Drug Canagliflozin Hinders Skeletal Muscle Regeneration in Mice

    In vivo muscle contractile properties recovery in mice ischemic lower limbs following gliflozins treatment was evaluated. The C2C12 myoblast differentiation after gliflozins treatment was also assessed in vitro.
    [Acta Pharmacologica Sinica]

    Abstract

    Muscle Stem Cell Polarity Requires QKI-Mediated Alternative Splicing of Integrin Alpha-7 (Itga7)

    Scientists defined the RNA-binding protein quaking as a major regulator alternative splicing of key muscle stem cells polarity factors including Dmd, Itga7, Mark2, and Numb.
    [Life Science Alliance]

    Full Article

    The Endothelial Dll4–Muscular Notch2 Axis Regulates Skeletal Muscle Mass

    Researchers revealed that multinucleated myofibres express Notch2, which played a crucial role in disuse- or diabetes-induced muscle atrophy.
    [Nature Metabolism]

    Abstract

    Development of a High-Yield Isolation Protocol Optimized for the Retrieval of Active Muscle Satellite Cells from Mouse Skeletal Muscle Tissue

    The authors reported an effective isolation protocol to economically and conveniently retrieve active mesenchymal stem cells from skeletal muscle tissues in mice.
    [International Journal of Stem Cells]

    Abstract

    Uhrf1 Governs the Proliferation and Differentiation of Muscle Satellite Cells

    Scientists demonstrated that a key epigenetic regulator, ubiquitin like with PHD and RING finger domains 1 (Uhrf1), was activated in proliferating myogenic cells but not expressed in quiescent satellite cells or differentiated myogenic cells in mice.
    [iScience]

    AbstractGraphical Abstract

    A Fast Myosin Super Enhancer Dictates Muscle Fiber Phenotype through Competitive Interactions with Myosin Genes

    Researchers identified by snATAC-seq a 42 kb super-enhancer at the locus regrouping the fast Myosin genes.
    [Nature Communications]

    Full Article

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    REVIEWS

    Interleukin 6 as an Energy Allocator in Muscle Tissue

    Scientists combined an evolutionary perspective with physiological data to propose that IL-6’s context-dependent effects on metabolism reflect its adaptive role for short-term energy allocation.
    [Nature Metabolism]

    Abstract

    INDUSTRY AND POLICY NEWS

    Cytokinetics Announces Start of SEQUOIA-HCM, a Phase III Clinical Trial of Aficamten in Patients with Symptomatic Obstructive Hypertrophic Cardiomyopathy

    Cytokinetics, Inc. announced that SEQUOIA-HCM (Safety, Efficacy, and Quantitative Understanding of Obstruction Impact of Aficamten in HCM), a Phase III clinical trial of aficamten in patients with symptomatic obstructive hypertrophic cardiomyopathy, is open to enrollment.
    [Cytokinetics, Inc.]

    Press Release

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