Muscle Cell News Volume 7.07 | Mar 7 2022

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    2022-03-06 | MUSCN 7.07


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.07 – 7 March, 2022
    TOP STORY

    Platelet-Derived TGF (Transforming Growth Factor)-β1 Enhances the Aerobic Glycolysis of Pulmonary Arterial Smooth Muscle Cells by PKM2 Upregulation

    Researchers investigated pulmonary arterial smooth muscle cell aerobic glycolysis after being treated with platelet supernatant. TGF-βRI, PKM2, and other antagonists were applied to identify the underlying mechanism
    [Hypertension]

    Abstract

    PUBLICATIONSRanked by the impact factor of the journal

    MYOCD Is Required for Cardiomyocyte-Like Cells Induction from Human Urine Cells and Fibroblasts through Remodeling Chromatin

    Researchers reported human urine cells could be converted into CM-like cells from different donors and the related chromatin accessibility dynamics by assay for transposase accessible chromatin-seq.
    [Stem Cell Reviews and Reports]

    Abstract

    Forensic and Clinical Applications of Biomarkers of Cardiovascular Disease

    Ferroptosis may be involved in the occurrence and development of Ischemic heart disease (IHD). Primary cardiomyocytes were treated with H2O2 to simulate the IHD in vitro model.
    [Disease Markers]

    Full Article

    Nicotinic Acid Riboside Regulates Nrf-2/P62-Related Oxidative Stress and Autophagy to Attenuate Doxorubicin-Induced Cardiomyocyte Injury

    Researchers studied the protective effects of nicotinic acid riboside on Dox-induced cardiotoxicity in vivo and in vitro.
    [Biomed Research International]

    Full Article

    Sox9 Promotes Cardiomyocyte Apoptosis after Acute Myocardial Infarction by Promoting miR-223-3p and Inhibiting MEF2C

    Researchers probe the role of Sox9 in cardiomyocyte apoptosis after acute myocardial infarction (AMI). AMI cell model was established in AC16 cells by hypoxia treatment.
    [Molecular Biotechnology]

    Abstract

    MicroRNA-24-3p Promotes Skeletal Muscle Differentiation and Regeneration by Regulating HMGA1

    Researchers reported on the role and mechanism of miR-24-3p in skeletal muscle differentiation and regeneration.
    [Cellular and Molecular Life Sciences]

    Abstract

    Muscle Stem Cell Function Is Impaired in β2-Adrenoceptor Knockout Mice

    Quiescent satellite cells were isolated by fluorescence-activated cell sorting, and cell cycle entry was assessed by EdU incorporation.
    [Stem Cell Reviews and Reports]

    Abstract

    Myoblast 3D Bioprinting to Burst In Vitro Skeletal Muscle Differentiation

    Scientists assessed the impact of different hydrogels on the viability, proliferation, and differentiation of murine myoblasts encapsulated in 3D bioprinted constructs aided to muscle regeneration.
    [Tissue Engineering and Regenerative Medicine]

    Full Article

    Human Pulmonary Artery Smooth Muscle Cell Dysfunction Is Regulated by miR-509-5p in Hypoxic Environment

    The role of miR-509-5p in hypoxia-induced pulmonary arterial smooth muscle cells (PASMCs) and the underlying mechanism were explored. PASMCs were cultured under both normoxia and hypoxia conditions.
    [Cell Cycle]

    Abstract

    Apolipoprotein J Attenuates Vascular Restenosis by Promoting Autophagy and Inhibiting the Proliferation and Migration of Vascular Smooth Muscle Cells

    The interaction between ATG and LC3 was analyzed, followed by validation of the role of autophagy in CLU’s regulation on the proliferation and migration of VSMCs.
    [Journal of Cardiovascular Translational Research]

    AbstractGraphical Abstract

    Curcumin Alleviates Lipopolysaccharides-Induced Inflammation and Apoptosis in Vascular Smooth Muscle Cells via Inhibition of the NF-κB and JNK Signaling Pathways

    Researchers investigated the effect of curcumin on vascular smooth muscle cells inflammation induced by lipopolysaccharide and its mechanism.
    [inflammopharmacology]

    Abstract

    REVIEWS

    Mitochondrial-Apoptotic Signaling Involvement in Remodeling during Myogenesis and Skeletal Muscle Atrophy

    Scientists review the role of mitochondrial apoptotic signaling in skeletal muscle remodeling during myogenic differentiation and skeletal muscle pathological states, including aging, disuse, and muscular dystrophy.
    [Seminars in Cell & Developmental Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Fulcrum Therapeutics® Announces REACH, a Phase 3 Clinical Trial of Losmapimod in Facioscapulohumeral Muscular Dystrophy (FSHD)

    Fulcrum Therapeutics, Inc. announced its plans to initiate REACH, a Phase III clinical trial of losmapimod in people with facioscapulohumeral muscular dystrophy, in the second quarter of 2022.
    [Fulcrum Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Metabolites in Signaling and Disease

    April 3 – April 5, 2022
    Lisbon, Portugal

    > See All Events

    JOB OPPORTUNITIES

    Assistant/Associate Professor – Pharmacogenetics

    University of Ottawa – Ottawa, Ontario, Canada

    Histologist – Immunofluorescence and Immunohistochemistry

    Sarepta Therapeutics Inc. – Columbus, Ohio, United States

    Postdoctoral Fellow – Neurodegeneration

    Institute of Molecular Biology and Genetics – Valladolid, Spain

    Research Scientist – Cardiobiology

    Ksilink – Strasbourg, France

    Postdoctoral Position – Skeletal Muscle Stem Cells

    Institut National de la Santé et de la Recherche Médicale – Lyon, France

    > See All Jobs

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