 | | Vol. 7.08 – 14 March, 2022 |
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| Researchers proposed an in situ-crosslinking gellan gum-based hydrogel tethered with a skeletal muscle-inspired laminin-derived peptide RKRLQVQLSIRTC(Q) and encapsulated with skeletal muscle cells.
[Acta Biomaterialia] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported that SIRT1, the most conserved NAD+-dependent protein deacetylase highly expressed in perinatal heart, played an important role in regulating cardiomyocyte remodeling during development.
[Journal of Cell Science] |
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| Researchers showed that glucocorticoids suppressed cardiomyocyte (CM) proliferation in vitro and in vivo, decreased the total number of CMs, and increased the cross-sectional area of CMs.
[Molecular and Cellular Endocrinology] |
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| The authors investigated the mechanism of the long noncoding RNA Rian in myocardial ischemia–reperfusion injury-induced cardiomyocyte pyroptosis.
[Hypertension Research] |
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| Scientists investigated the efficacy of recombinant human endostatin combined with radiation on rat cardiomyocyte apoptosis and the regulatory mechanism of transforming growth factor beta1 /Sma and Mad-related protein 3/connective tissue growth factor signaling.
[BMC Cardiovascular Disorders] |
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| Steady-state and stable isotope flux analyses demonstrated increased rates of glycolysis, acetyl-CoA production, acetylcholine levels and density of neuromuscular synaptic junction clusters with enhanced acetylcholine release.
[eLife] |
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| RGMa expression patterns and signaling pathways via Neogenin and/or as BMP coreceptors indicated that this axon guidance molecule could also be working in other processes and diseases, including during myogenesis.
[BMC Genomics] |
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| The authors hypothesized that vascular smooth muscle cell undergoes dysregulation in advanced type 2 diabetes mellitus which was associated with vascular hyperacetylation.
[Molecular Medicine] |
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| Researchers investigated whether aortic stiffness was modulated by a shorter duration of autophagy deficiency.
[Journal of Physiological Sciences] |
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| Scientists provide knowledge of the regulatory mechanisms that control substrate partitioning to coordinate biosynthesis with energy provision could be leveraged to prompt or augment cardiomyocyte division and to promote cardiac repair.
[Stem Cells] |
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| Investigators summarize the changes in active and passive mechanical properties at the single muscle cell level in older skeletal muscles.
[European Journal of Applied Physiology] |
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| BridgeBio Pharma, Inc. announced positive data from the Phase II study of BBP-418 in patients with lgmd2i.
[BridgeBio Pharma, Inc.] |
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| April 7 – April 9
Rome, Italy & Virtual |
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| NIH National Institute on Aging – Baltimore, Maryland, United States |
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| Sarepta Therapeutics Inc. – Columbus, Ohio, United States |
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| Institute of Molecular Biology and Genetics – Valladolid, Spain |
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| Ksilink – Strasbourg, France |
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| Institut National de la Sant̩ et de la Recherche M̩dicale РLyon, France |
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