 | | Vol. 7.09 – 21 March, 2022 |
| |
|
|
| Researchers demonstrated that quiescent muscle stem cells were morphologically heterogeneous and exhibited different patterns of cellular protrusions.
[Science Advances] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| To examine the effects of chronic 4-hydroxytamoxifen treatment, investigators used state-of-the-art human-induced pluripotent stem cell-derived cardiomyocytes and a bioengineered platform to model duchenne muscular dystrophy.
[NPJ Regenerative Medicine] |
|
|
|
| Scientists analyzed whole-genome sequencing data in a discovery cohort of 209 pediatric cardiomyopathy patients and 1953 independent replication genomes and exomes and searched for protein-coding variants and non-coding variants predicted to affect the function or expression of genes.
[NPJ Genomic Medicine] |
|
|
|
| Catalpol promoted the viability and reduced cell apoptosis of human cardiomyocyte AC16 cells and repressed the release of inflammatory cytokines TNF-α, IL-6, and IL-1β, while inhibiting the leakage of myocardial injury markers lactate dehydrogenase and creatine kinase.
[Journal of Biochemical and Molecular Toxicology] |
|
|
|
| The authors identified cell-specific transcriptional signatures associated with age and heart failure and revealed the emergence of disease-associated cell states.
[Nature Cardiovascular Research] |
| |
|
|
| Investigators found that the ability of muscle stem cells to regenerate was regulated by the primary cilium, a cellular protrusion that served as a sensitive sensory organelle.
[Nature Communications] |
|
|
|
| To determine whether skeletal muscle miR-486 was functionally similar in dystrophies and cancer, the authors performed functional limitations and biochemical studies of skeletal muscles of MMTV-Neu mice that mimicked HER2+ breast cancer and MMTV-PyMT mice that mimicked luminal subtype B breast cancer.
[Molecular Therapy-Nucleic Acids] |
|
|
|
| Researchers investigated whether sotagliflozin, an anti-hyperglycemia SGLT2 inhibitor, exerted therapeutic angiogenesis effects in diabetic hindlimb ischemia in vitro and in vivo.
[Acta Pharmacologica Sinica] |
| |
|
|
| Scientists analyzed the role of galectin-1, a β-galactoside–binding protein, as a therapeutic target for atherosclerosis and abdominal aortic aneurysm.
[Science Advances] |
|
|
|
| The authors showed that extracellular vesicles derived from aged bone matrix during bone resorption favored bone marrow mesenchymal stem cell adipogenesis rather than osteogenesis and augmented calcification of vascular smooth muscle cells.
[Nature Communications] |
|
|
|
| Investigators focused on how miR-98-5p functioned in the proliferation and migration of human airway smooth muscle cells treated with interleukin-13 (IL-13).
[Inflammation] |
|
|
|
|
| The authors discuss the therapeutic strategies to alter sarcomere contractile activity and summarize the data indicating that targeting one protein in the sarcomere can be effective in treating patients with genetic variants in other sarcomeric proteins, as well as in patients with non-sarcomere-based disease.
[Nature Reviews Cardiology] |
|
|
|
| Scientists review various modalities to evaluate the function of human stem cell-derived cardiac tissues and introduce heart-on-a-chip systems that can recapitulate physiological parameters of human pluripotent stem cell-derived cardiac tissues.
[Stem Cells] |
|
|
|
| Involvement of the cardiovascular system in COVID-19 has important consequences during recovery from infection and the development of long COVID.
[Nature Cardiovascular Research] |
|
|
|
|
| PepGen, Inc. announced approval by Health Canada of PepGen’s Clinical Trial Application (CTA) authorizing initiation of first-in-human trials of PepGen’s lead Enhanced Delivery Oligonucleotide (EDO) candidate, PGN-EDO51, to treat individuals with Duchenne muscular dystrophy.
[PepGen, Inc.] |
|
|
|
|
| April 8 – 13, 2022
New Orleans, Louisiana, United States |
|
|
|
|
|
| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
|
|
|
| | Genentech, Inc. – South San Francisco, California, United States |
|
|
|
| | Gilead Sciences – Foster City, California, United States |
|
|
|
| NIH National Institute on Aging – Baltimore, Maryland, United States |
|
|
|
| University of Ottawa – Ottawa, Ontario, Canada |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
