 | | Vol. 7.13 – 18 April, 2022 |
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| Scientists systematically studied the impact of matrix stiffness and (hemodynamic) pressure on vascular smooth muscle cells (VSMCs). They found that pressure and stiffness individually affected the VSMC phenotype.
[Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that estrogen-related receptors (ERR) signaling was necessary for induction of genes involved in mitochondrial and cardiac-specific contractile processes during human induced pluripotent stem cell-derived cardiomyocyte differentiation.
[Nature Communications] |
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| Inhibition of histone deacetylase 3 (HDAC3) or overexpression of NOL3 ameliorated the promotive effects of ATXN1L on cardiomyocyte apoptosis and pyroptosis.
[Journal of Molecular Medicine] |
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| Investigators compared and optimized protocols for the isolation of cardiomyocytes (CMs) from embryonic to adult stages. They found that the trypsin digestion method was suitable for embryonic mouse CM isolation.
[Journal of Molecular and Cellular Cardiology] |
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| Scientists indicated that CD137 signaling aggravated cardiac ischemia–reperfusion injury by inducing myocardial cell necrosis.
[Journal of Cardiovascular Translational Research] |
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| The authors demonstrated a 3D edible chitosan‑sodium alginate-collagen/gelatin scaffold that could support the adhesion and proliferation of porcine skeletal muscle satellite cells, culminating in the construction of a structured cell cultured meat model.
[International Journal of Biological Macromolecules] |
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| Researchers examined the effects of endoplasmic reticulum (ER) stress on peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) levels in muscle and the potential mechanisms involved. The human skeletal muscle cell line LHCN-M2 and mice exposed to different inducers of ER stress were used.
[Cell Communication and Signaling] |
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| Investigators found that benzopyrene exposure led to the inhibition of C2C12 myoblasts differentiation in a dose-dependent manner and reduced the expression of both early and late myogenic differentiation markers.
[Toxicology in Vitro] |
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| Scientists found that a portion of H2O2-treated vascular smooth muscle cells (VSMCs) underwent senescence, and that conditioned medium of H2O2-treated senescent VSMCs triggered the proliferation of quiescent VSMCs.
[ACS Biomaterials Science & Engineering] |
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| Vascular smooth muscle cells (VSMCs) were treated by oxidized low-density-lipoprotein (oxLDL)-stimulated-macrophages (MФ) with/without GW4869. MiRNA profile in oxLDL-stimulated-MФ and untreated-MФ was detected by microarray, then candidate miRNAs were proposed to RT-qPCR and functional validation in VSMCs.
[Molecular Immunology] |
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| The authors found that chaetocin suppressed the migration of vascular smooth muscle cells (VSMC). Moreover, chaetocin treatment induced a contractile phenotype in VSMCs by increasing α-SMA and SM22α expression.
[Journal of Cardiovascular Translational Research] |
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| Scientists review recent advances, current challenges, and future perspectives to build human skeletal muscle tissue “in a dish”, focusing on the cellular constituents and on applications for in vitro disease modeling.
[Experimental Cell Research] |
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| Addex Therapeutics Ltd announced that patient enrollment has been completed in its Phase IIa clinical study evaluating dipraglurant as a potential treatment for blepharospasm, a type of dystonia characterized by involuntary contractions or spasms of the eyelid muscles.
[Addex Therapeutics Ltd] |
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| AEON Biopharma, Inc. announced the completion of patient enrollment in the Phase II clinical study of ABP-450 for the treatment of cervical dystonia.
[AEON Biopharma, Inc.] |
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| June 19 – 24, 2022
Smithfield, Rhode Island, United States |
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| | Pfizer – Cambridge, Massachusetts, United States |
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| | Harvard University – Cambridge, Massachusetts, United States |
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| | NIH National Heart, Lung, and Blood Institute – Bethesda, Maryland, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | University of California, San Diego – La Jolla, California, United States |
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