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| Researchers assessed HAPLN1 expression in published single-cell RNA sequencing data sets from different stages and injury states of murine and human hearts and performed molecular genetics to determine the requirements for hapln1-expressing cells and functions of each hapln1 paralog.
[Circulation] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists performed single-cell RNA-Seq in postnatal rat hearts in order to identify the important factors for cardiomyocyte maturation.
[Cardiovascular Research] |
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| The authors reported the development of a standardized method that allowed for rapid isolation and purification of high-quality cardiomyocytes from individual neonatal through to adult C57BL/6 J murine hearts.
[Journal of Molecular and Cellular Cardiology] |
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| Protein/pathway alterations for skeletal muscle development were identified comparing proteomic profiles of C2C12 cells differentiated on poly(vinylidene fluoride), with similar cells differentiated on a polystyrene plate, using label-free liquid chromatography–tandem mass spectrometry.
[ACS Applied Materials & interfaces] |
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| Investigators characterized a microphysiological system in which engineered skeletal muscle myobundles derived from donor-specific satellite cells that model aged phenotypes were encapsulated in a perfused tissue chip platform containing platinum electrodes.
[Aging Cell] |
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| The authors reported that the fibro-adipogenic progenitor subpopulation expressing Dpp4 was required for the neuromuscular system.
[JCI Insight] |
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| In vitro experiments found that the water extract of safflower could significantly increase myosin heavy chain I (MyHC I), myoglobin, and troponin I mRNA expression while downregulating MyHC IIb mRNA expression.
[Food & Function] |
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| Using combined genetic fate tracing with confocal imaging and single-cell RNA sequencing of the cardiac vascular niche in homeostasis and during heart failure, investigators unraveled cell type-specific transcriptomic changes in fibroblast, endothelial, pericyte, and vascular smooth muscle cell subtypes.
[Nature Communications] |
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| Scientists reported a patient with a heterozygous 22q11.2 deletion/DiGeorge syndrome who developed a unique, broad, and lethal susceptibility to Epstein–Barr virus (EBV) characterized by EBV-infected T and B cells and disseminated EBV+ smooth muscle cell tumor.
[Journal of Experimental Medicine] |
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| Researchers used miR-22 as balloon-loaded drugs and polyelectrolyte complexes polyethyleneimine/polyacrylic acid as balloon coatings to establish a new drug-coated balloon system through the ultrasonic spray method.
[Biomaterials Science] |
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| Investigators developed a dynamic, rhythmically stretching, 3D microphysiological model and used patient-derived human aortic smooth muscle cells to test its biological features.
[Ebiomedicine] |
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| The advent of induced pluripotent stem cells has paved the way for new in vitro models of human cardiomyopathy. The authors review existing models of disease as well as the strengths and limitations of the system.
[Current Cardiology Reports] |
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| Roche announced that the US FDA has approved a label extension for Evrysdi® (risdiplam) to include babies under two months old with SMA.
[Roche] |
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| September 11 – 16, 2022
Ventura, California, United States |
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| | Electrophysiology and Heart Modeling Institute – Bordeaux, France |
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| | Norwegian University of Science and Technology -Trondheim, Norway |
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| | Utrecht University – Utrecht, Netherlands |
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| | Shenzhen Institute of Advanced Technology Chinese Academy of Sciences – Shenzhen, Guangdong, China |
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