Patient-Derived Microphysiological Model Identifies the Therapeutic Potential of Metformin for Thoracic Aortic Aneurysm

Using patient-derived human aortic smooth muscle cells, scientists tested the biological features of the model and compared them with native aortic tissues. Drug testing was performed on the individualized thoracic aortic aneurysm models, and the potentially effective drug was further tested using β-aminopropionitrile-treated mice and retrospective clinical data.