 | | Vol. 7.21 – 20 June, 2022 |
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| Scientists deleted Hdac3 in the developing murine epicardium, and mutant hearts showed ventricular myocardial wall hypoplasia with reduction of epicardium-derived cells.
[Circulation Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that the activation of the growth hormone-releasing hormone receptor signaling pathway within the myocardium both prevented and reversed diastolic dysfunction and pathophysiologic features consistent with heart failure with preserved ejection fraction (HFpEF).
[Cardiovascular Research] |
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| Investigators evaluated the potential of 4 epigenetic drugs, including the recently developed histone deacetylase 6 inhibitor JS28, to prevent endothelin‐1 induced pathological gene expression in cardiac myocytes and analyzed the chromatin binding profile of the respective inhibitor targets.
[Journal of the American Heart Association] |
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| Scientists investigated whether SSEA4+CD34– cells constituted immature cycling cardiomyocytes in the adult failing and non-failing human heart.
[PLoS One] |
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| Single-cell RNA-sequencing of regenerating Mus musculus skeletal muscle revealed that RNA-binding protein (RBP) expression, including the expression of many neuromuscular disease-associated RBPs, was temporally regulated in skeletal muscle stem cells and correlated with specific stages of myogenic differentiation.
[Stem Cells and Regenerative Medicine] |
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| Data revealed cross talk between dystrophin and FAs, as the expression of wild-type or I232M dystrophin increased focal adhesions tension compared to dystrophin-less nontransgenic myoblasts.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors showed that the CLOCK-interacting protein circadian (CIPC) a negative-feedback regulator of the circadian clock, was up-regulated during myoblast differentiation.
[Cell Reports] |
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| Researchers investigated the effects of lysyl oxidase-like 2 inhibitor on D-galactose-induced skeletal muscle fibroblast cells and mice.
[Aging Cell] |
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| Scientists investigated the mechanism of methyltransferase-like 3 (METTL3) in atherosclerosis plaques via modulating the phenotypic transformation of vascular smooth muscle cells.
[Cardiovascular Drugs and Therapy] |
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| The role of mitofusin 2 in the physical and functional couplings between sarcoplasmic reticulum and mitochondria was examined in rat aortic smooth muscle cells by confocal and electron microscope imaging.
[American Journal of Physiology-Cell Physiology] |
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| Investigators explored the potential of tRNA-derived small RNAs (tsRNAs) in human aortic smooth muscle cell proliferation. High-throughput sequencing was performed to analyze the tsRNA expression profile of proliferative and quiescent HASMCs.
[Cellular & Molecular Biology Letters] |
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| Scientists determined the role of Yes-associated protein (YAP) in abdominal aortic aneurysm formation and the underlying mechanism.
[Journal of Cardiovascular Translational Research] |
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| The authors investigated the spatial and molecular compositional associations of renal Schwann cells (SC) supporting the nerve terminals in male rats.
[Journal of Histochemistry & Cytochemistry] |
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| Scientists discuss different mechanisms involving both cardiomyocytes and non-myocyte alterations for the transition of cardiac hypertrophy to heart failure as well as for the progression of heart failure.
[Canadian Journal of Physiology and Pharmacology] |
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| The authors review advances in understanding of sepsis‑induced cardiomyocyte death pathways, including apoptosis, necroptosis, mitochondria‑mediated necrosis, pyroptosis, ferroptosis and autophagy.
[Molecular Medicine Reports] |
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| The National Cancer Institute, part of the National Institutes of Health, announced that four international research teams had been selected to receive a total of $100 million as part of the Cancer Grand Challenges program.
[Forbes] |
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| December 8 – 10, 2022
Los Angeles, California, United States |
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| | Aarhus University – Aarhus C, Denmark |
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| | Washington University School of Medicine – St. Louis, Missouri, United States |
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| | University of California, San Diego – La Jolla, California, United States |
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| | Electrophysiology and Heart Modeling Institute – Bordeaux, France |
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| | Norwegian University of Science and Technology -Trondheim, Norway |
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