Muscle Cell News Volume 7.27 | Aug 8 2022

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    2022-08-08 | MUSCN 7.27


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.27 – 8 August, 2022
    TOP STORY

    Modulating Lysine Crotonylation in Cardiomyocytes Improves Myocardial Outcomes

    Investigators clarified the pathophysiological significance of lysine crotonylation in cardiac injury and explored the underlying mechanism.
    [Circulation Research]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Functional Isolation, Culture and Cryopreservation of Adult Human Primary Cardiomyocytes

    Scientists established a full set of methodologies for the efficient isolation and prolonged maintenance of functional primary adult human cardiomyocytes in vitro.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Targeting Transcription in Heart Failure via CDK7/12/13 Inhibition

    Researchers demonstrated that CDK7/12/13 were critical regulators of transcription activation in the heart that could be pharmacologically inhibited to improve heart failure with reduced ejection fraction.
    [Nature Communications]

    Full Article

    Substantial Impact of 3-Iodothyronamine (T1AM) on the Regulations of Fluorescent Thermoprobe-Measured Cellular Temperature and Natriuretic Peptide Expression in Cardiomyocytes

    Scientists explored the direct impact of T1AM on cardiomyocytes with a focus on the regulation of the intracellular temperature and natriuretic peptide expression.
    [Scientific Reports]

    Full Article

    ZAKβ Is Activated by Cellular Compression and Mediates Contraction-Induced MAP Kinase Signaling in Skeletal Muscle

    Investigators showed that the upstream MAP3K ZAKβ was activated by cellular compression induced by osmotic shock and cyclic compression in vitro, and muscle contraction in vivo.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Ribonucleotide Reductase M2B in the Myofibers Modulates Stem Cell Fate in Skeletal Muscle

    The balance among quiescence, differentiation, and self-renewal of skeletal muscle stem cells (MuSCs) was tightly regulated by their intrinsic and extrinsic properties from the niche. Researchers investigated how the niche controls MuSC fate.
    [NPJ Regenerative Medicine]

    Full Article

    R-spondin3 Is a Myokine That Differentiates Myoblasts to Type I Fibres

    To examine whether R-spondin (Rspo3) induced type I fibres, primary myoblasts prepared from mouse soleus muscles were exposed to a differentiation medium containing the mouse recombinant Rspo3 protein.
    [Scientific Reports]

    Full Article

    Dysregulation of Tweak and Fn14 in Skeletal Muscle of Spinal Muscular Atrophy Mice

    The authors investigated the potential role of the tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 pathway in spinal muscular atrophy muscle pathology.
    [Skeletal Muscle]

    Full Article

    Unbiased Proteomic Analysis of Extracellular Vesicles Secreted by Senescent Human Vascular Smooth Muscle Cells Reveals Their Ability To Modulate Immune Cell Functions

    Investigators demonstrated that senescent vascular smooth muscle cells secrete increased number of extracellular vesicles.
    [GeroScience]

    Full Article

    Myocardin Regulates Exon Usage in Smooth Muscle Cells Through Induction of Splicing Regulatory Factors

    Researchers identified four splicing factors (MBNL1, RBPMS, RBPMS2, and RBFOX2) that correlated with myocardin across human smooth muscle cell tissues.
    [Cellular and Molecular Life Sciences]

    Full Article

    The Crosstalk Between Endothelial Cells and Vascular Smooth Muscle Cells Aggravates High Phosphorus-Induced Arterial Calcification

    The osteogenic differentiation of vascular smooth muscle cells (VSMCs) was the critical process for the development of arterial calcification, highly prevalent in patients with end-stage renal disease. Scientists eludicated the detailed mechanism of VSMCs calcification.
    [Cell Death & Disease]

    Full Article
    An ISSCR 2022 COREdinates Webinar: Differentiation of High-Quality hPSCs Using STEMdiff â„¢ and TeSR â„¢-AOF, presented by Kim Snyder. Click to Watch Now.
    REVIEWS

    Transcriptional Regulation of Vascular Smooth Muscle Cell Proliferation, Differentiation and Senescence: Novel Targets for Therapy

    The authors review recent advances in their understanding of regulatory mechanisms governing smooth muscle cell phenotypic modulation.
    [Vascular Pharmacology]

    AbstractGraphical Abstract

    P2Y1R and P2Y2R: Potential Molecular Triggers in Muscle Regeneration

    Scientists summarize muscle regeneration via P2Y1R and P2Y2R and speculated that P2Y1R and P2Y2R might be potential molecular triggers for muscle stem cells’ activation and proliferation via the p-ERK1/2 and phospholipase C pathways.
    [Purinergic Signalling]

    Full Article
    INDUSTRY AND POLICY NEWS

    Entrada Therapeutics Announces Collaboration with the Myotonic Dystrophy Clinical Research Network to Study the Natural History of Myotonic Dystrophy Type 1

    Entrada Therapeutics, Inc. announced a new collaboration with the Myotonic Dystrophy Clinical Research Network supporting Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1.
    [Entrada Therapeutics, Inc.]

    Press Release

    UK Charity Gives $36 Million Boost to Gene Editing for Inherited Heart Diseases

    In the biggest research grant ever from the research charity, the British Heart Foundation announced an award of £30 million over five years to an international team to develop gene-editing treatments for deadly heart conditions.
    [ScienceInsider]

    Press Release

    FEATURED EVENT

    The Matrix in Development

    September 12 – 14, 2022
    Liverpool, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Research Scientist – Cardiovascular & Heart Research

    Nationwide Children’s Hospital – Columbus, Ohio, United States

    Research Scientist – Inflammation

    Gilead Sciences, Inc. – Foster City, California, United States

    Research Assistant Professor – Cardiovascular and Regenerative Medicine

    Ohio State University Wexner Medical Center – Columbus, Ohio, United States

    Postdoctoral Research Fellow – Muscle Biology

    Cincinnati Children’s Hospital Medical Center – Cincinnati, Ohio, United States

    Histologist – Muscle & Nerve Tissue

    Sarepta Therapeutics, Inc. – Columbus, Ohio, United States

    > See All Jobs

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