Muscle Cell News Volume 7.30 | Aug 29 2022

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    2022-08-29 | MUSCN 7.30


    Muscle Cell News by STEMCELL Technologies
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    Vol. 7.30 – 29 August, 2022

    Single-Cell Analysis and Functional Characterization Uncover the Stem Cell Hierarchies and Developmental Origins of Rhabdomyosarcoma

    Fusion-negative rhabdomyosarcoma (RMS) cells resembled early myogenic cells found in embryonic and fetal development, while fusion-positive RMS cells expressed a highly specific gene program found in muscle cells transiting from embryonic to fetal development at 7-7.75 weeks of age.
    [Nature Cancer]

    Abstract
    Five tips for returning to the lab after time off
    PUBLICATIONSRanked by the impact factor of the journal

    Bioinspired Two-in-One Nanotransistor Sensor for the Simultaneous Measurements of Electrical and Mechanical Cellular Responses

    The authors demonstrated integrated nanoelectronic sensors capable of simultaneously probing electrical and mechanical cellular responses.
    [Science Advances]

    Full ArticlePress Release

    Sphingosine-1-Phosphate Attenuates Endoplasmic Reticulum Stress-Induced Cardiomyocyte Apoptosis through Sphingosine-1-Phosphate Receptor 1

    Researchers investigated the regulatory role of sphingosine-1-phosphate in endoplasmic reticulum stress-induced apoptosis in cardiomyocytes.
    [Archives of Medical Research]

    AbstractGraphical Abstract

    Testosterone Protects Cardiomyocytes Against Hydrogen Peroxide-Induced Aging by Upregulating IGF1 and SIRT1 Pathways

    Scientists investigated the role of IGF1 and SIRT1 pathways in protection of hydrogen peroxide-induced aging in H9c2 rat cardiomyocyte cells by testosterone.
    [Physiology International]

    Abstract

    Mitochondrial Dynamics Maintain Muscle Stem Cell Regenerative Competence throughout Adult Life by Regulating Metabolism and Mitophagy

    Researchers showed that mitochondrial dynamics were essential for the successful regenerative capacity of satellite cells.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract

    The Mitochondrial Protein OPA1 Regulates the Quiescent State of Adult Muscle Stem Cells

    Investigators showed that muscle stem cells mitochondria rapidly fragmented upon an activation stimulus, via systemic HGF/mTOR, to drive the exit from deep quiescence.
    [Cell Stem Cell]

    Full ArticleGraphical Abstract

    Cellular Mechanisms of Oligoclonal Vascular Smooth Muscle Cell Expansion in Cardiovascular Disease

    The authors investigated the dynamics of vascular smooth muscle cells (VSMCs) clone formation using confocal microscopy and single cell transcriptomics in VSMC-lineage-traced animal models.
    [Cardiovascular Research]

    Abstract
    Graphical Abstract

    Phosphodiesterase 4D Contributes to Angiotensin II-Induced Abdominal Aortic Aneurysm through Smooth Muscle Cell Apoptosis

    Scientists showed that phosphodiesterase 4D expression was upregulated in human and angiotensin II-induced mouse abdominal aortic aneurysm tissues using RT-PCR, western blotting, and immunohistochemical staining.
    [Experimental & Molecular Medicine]

    Full Article
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    REVIEWS

    Muscle and Bone Defects in Metastatic Disease

    Investigators address most recently identified mechanisms implicated in metastasis-induced bone resorption and muscle-wasting syndrome, known as cachexia.
    [Current Osteoporosis Reports]

    Full Article
    INDUSTRY AND POLICY NEWS

    Baylor College of Medicine Recognizes Research Excellence with DeBakey Awards

    Each year, Baylor College of Medicine faculty are recognized for their outstanding published scientific contributions to clinical and basic science research over the past three years through the Michael E. DeBakey MD Award for Excellence in Research.
    [Baylor College of Medicine]

    Press Release
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    Emerging Cellular Therapies at the Forefront of Cancer Immunotherapy

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    JOB OPPORTUNITIES

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    Duke University – Durham, North Carolina, United States

    Postdoctoral Fellowship – Translational Cardiovascular Medicine

    University of Alberta – Edmonton, Alberta, Canada

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