 | | Vol. 7.34 – 3 October, 2022 |
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| Investigators studied the expression and function of Orai1 in human pulmonary artery smooth muscle cells (hPASMCs) isolated from patients with pulmonary arterial hypertension (PAH). They discovered that Orai1 contributed to pathological phenotypes in PAH-hPASMCs, as well as pulmonary remodeling.
[Circulation Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists proposed a novel strategy to engineer highly-aligned 3D cardiac constructs by co-culturing cardiomyocytes and rat aortic endothelial cells along with extracellular matrix-derived fibrin within electrohydrodynamic-printed microfibrous architectures.
[Biofabrication] |
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| Investigators presented that ablation of Rbl2 increased cardiomyocyte apoptosis following acute myocardial ischemia and reperfusion injury, leading to diminished cardiac function and exaggerated ventricular remodeling.
[Journal of the American Heart Association] |
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| Scientists investigated the global landscape of syndecan-3 (SDC3)-mediated regulation of myogenesis with a rapid downregulation of SDC3 and regulation of signal transduction in muscle stem cells to restrain proliferation response and premature differentiation.
[Matrix Biology] |
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| Researchers made the first discovery of convergent abnormalities in primary mouse and human dystrophic myoblasts. They found satellite cell defects in Duchenne muscular dystrophy with myoblast dysfunction affecting muscle regeneration due to myofiber instability.
[eLife] |
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| Scientists investigated muscle regeneration in Marfan syndrome mouse models by analyzing the influence of the fibrotic niche on satellite cell function, as well as evaluated the effect of the pharmacological inhibition of fibrosis on regenerating skeletal muscles.
[Acta Physiologica] |
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| Researchers demonstrated a theophylline-responsive RNA-based regulatory system that provided conditional modulation of muscle myofiber differentiation in C2C12 myoblasts.
[PLoS One] |
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| By utilizing smooth muscle NCOR1 knockout mice, scientists demonstrated that NCOR1 deficiency decreased expression of contractile genes, impaired stress fibre formation, and reduced synthesis of elastin and collagens, manifesting a degradative phenotype of vascular smooth muscle cells.
[Cell Death & Differentiation] |
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| Investigators studied lung tissues from elderly asthmatics to explore whether senescent airway muscle cells contributed to airway structural or functional changes.
[American Journal of Physiology-Lung Cellular and Molecular Physiology] |
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| Researchers investigated whether DN200434 inhibited proliferation and migration of vascular smooth muscle cells, mitochondrial oxidative phosphorylation, and subsequently suppressed neointima formation in a mouse carotid artery ligation model.
[Endocrinology and Metabolism] |
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| The authors provide an up-to-date perspective on the dystrophin-glycoprotein complex (DGC). They discuss the relationship between muscle cell mechanics and function, as well as the role of the DGC in mechanotransduction and maintaining biomechanical integrity of muscle cells.
[Communications Biology] |
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| PepGen, Inc. announced results from its completed Phase I healthy normal volunteer trial of PGN-EDO51, the company’s lead product candidate for the treatment of Duchenne muscular dystrophy patients whose mutations were amenable to an exon 51 skipping approach.
[PepGen, Inc.] |
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| NMD Pharma A/S announced that the FDA has granted orphan-drug designation for NMD670, its lead product candidate in development for the treatment of myasthenia gravis.
[NMD Pharma A/S] |
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| November 12 – 16, 2022
San Diego, California, United States |
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| | East Carolina University – Greenville, North Carolina, United States |
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| | Mount Sinai Health System – New York, New York, United States |
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| | Yale University – New Haven, Connecticut, United States |
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| | City of Hope – Duarte, California, United States |
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| | Syracuse University – Syracuse, New York, United States |
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