 | | Vol. 7.35 – 17 October, 2022 |
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| Investigators identified a lncRNA named lncRNA muscle regeneration enhancement factor (lncMREF) as a conserved positive regulator of muscle regeneration among mice, pigs, and humans.
[Nucleic Acids Research] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| While monitoring cardiomyocyte proliferation capacity in mice models lacking 3-hydroxy-3-methylglutaryl-CoA synthase 2, the rate-limiting enzyme of ketogenesis, researchers discovered that neonatal ketone body elevation was a critical regulatory factor for postnatal heart development.
[Cell Discovery] |
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| Investigators tested whether sorafenib (Sor) disrupted autophagy and mitochondrial dynamics, thereby aggravating Sor-induced oxidative stress damage to cardiomyocytes.
[Toxicology] |
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| Scientists explored whether miR-363-3p played a role in the isoflurane-mediated protective effect of cardiomyocyte injury induced by hypoxia/reoxygenation.
[Neurotoxicity Research] |
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| Previously tested Malotilate treatment for liver degeneration, inflammation, and fibrosis was repurposed to investigate its effects in skeletal muscle atrophy by utilizing myotube-based models of skeletal muscle atrophy and aging.
[Journal of Cachexia Sarcopenia and Muscle] |
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| Researchers demonstrated that atrophic muscle fibre-derived small extracellular vesicle miR-690 inhibited satellite cell differentiation during aging-induced muscle atrophy, providing a fresh insight into sarcopenia and potential treatment strategies.
[Journal of Cachexia Sarcopenia and Muscle] |
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| Investigators explored the effect and mechanism of sulforaphane on hypoxic pulmonary hypertension in mouse models and in vitro studies on pulmonary artery smooth muscle cell proliferation and apoptosis.
[Journal of Nutritional Biochemistry] |
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| Scientists presented the effects of miR-499-5p in the proliferation and migration of vascular smooth muscle cells (VSMCs) utilizing aortic VSMCs to establish atherosclerosis model in vitro.
[Physiological Genomics] |
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| Investigators studied whether NR4A1 regulated intestinal smooth muscle cell proliferation and muscle thickening in the context of inflammation.
[FASEB Journal] |
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| The authors discuss the implications of hypoxia-inducible factors (HIF) and development of HIF-targeted drugs for cardioprotective therapy in protecting against myocardial ischemic injury and promoting recovery of cardiac function.
[Trends in Molecular Medicine] |
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| Investigators summarize the complex relationship between sleep, circadian biology, and skeletal muscle, and discusses the effectiveness of several strategies to mitigate the negative effects of disturbed sleep or circadian rhythms on skeletal muscle health.
[Sleep Medicine Reviews] |
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| The authors summarize the features and functions of arginase, the roles of arginase in cells of the vascular and cardiac system, as well as in the development of cardiovascular diseases.
[Cell Death Discovery] |
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| Greenstone Biosciences, Inc. announced that the company has received a DISC0 grant funding from the California Institute of Regenerative Medicine (CIRM).
[Greenstone Biosciences, Inc.] |
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| November 7 – 9, 2022
Singapore, Singapore |
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| | Karolinska Institute – Stockholm, Sweden |
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| | Katholieke Universiteit Leuven – Leuven, Belgium |
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| | Sanford Burnham Prebys Medical Discovery Institute – La Jolla, California, United States |
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| | University of Colorado Denver – Aurora, Colorado, United States |
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| | Institute of Tissue Regeneration Engineering – Cheonan, South Korea |
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