 | | Vol. 7.36 – 24 October, 2022 |
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| Researchers investigated and delineated the role of pyruvate dehydrogenase kinase 4 in the context of muscle atrophy, which could be identified as a potential therapeutic avenue to protect against dexamethasone-induced muscle wasting.
[Journal of Cachexia Sarcopenia and Muscle] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that ring-finger protein 5 (RNF5) expression was upregulated in animal and cellular models of cardiac hypertrophy.
[Cell Death & Disease] |
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| A fibrin-based cardiac patch loaded with neuregulin-1 (NRG-1) was developed to attach locally to the infarct area of the heart and exhibited good biocompatibility and promoted cardiomyocyte proliferation in vitro via NRG-1/ErbB signaling.
[Colloids and Surfaces B-Biointerfaces] |
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| | Investigators highlighted the important role of decrotonylation of AKT serine/threonine kinase 1 (AKT1) in the process of muscle differentiation, where it aided the phosphorylation and activation of AKT1 and promoted myogenic differentiation.
[Journal of Advanced Research] |
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| Scientists studied whether perturbations in the molecular catabolic-autophagy signaling network were linked to the temporal remodeling of skeletal muscle in hind limb ischemia.
[American Journal of Physiology-Cell Physiology] |
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| Researchers demonstrated joint delivery of human-derived endothelial progenitor cells and smooth muscle cells as a scaffold-free, bi-level cell sheet platform to improve ventricular remodeling and function in an athymic rat model of myocardial infarction.
[Scientific Reports] |
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| Investigators utilized human aortic vascular smooth muscle cells stimulated by high phosphate to investigate how bone marrow mesenchymal stem cell-derived exosomes relieve vascular calcification.
[Biochemical and Biophysical Research Communications] |
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| Scientists investigated the relationship between the decreased expression of natriuretic peptide receptor-C and vascular remodeling in spontaneously hypertensive rats and the underlying molecular mechanisms.
[Peptides] |
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| Investigators use vascular smooth muscle cell phenotypic transition in atherosclerosis (AS) to introduce the effect of exosomes on AS from different perspectives and discuss the status quo, deficiencies, and potential future directions to provide new ideas for clinical research and treatment.
[Cell Communication and Signaling] |
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| The authors provide a review of the application of Pax3/Pax7 factors as well as the mechanism and value of this protein innovation on gene regeneration and compare it with previous treatments.
[The Journal of Genetic Engineering and Biotechnology] |
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| Biogen Inc. announced that the FDA has extended the review period of the new drug application for tofersen by three months. Tofersen is an investigational treatment for superoxide dismutase amyotrophic lateral sclerosis.
[Biogen, Inc.] |
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| Solid Biosciences presented additional data characterizing AAV-SLB101, a novel adeno-associated virus vector designed for improved transduction efficiency and biodistribution to muscle cells.
[Solid Biosciences] |
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| November 14 – 17, 2022
Portland, Oregon, United States |
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| | University of East Anglia – Norwich, United Kingdom |
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| | University of London – Royal Veterinary College – London, United Kingdom |
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| | Karolinska Institute – Stockholm, Sweden |
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| | Katholieke Universiteit Leuven – Leuven, Belgium |
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| | University of Colorado Denver – Aurora, Colorado, United States |
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