Muscle Cell News Volume 7.37 | Oct 31 2022

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    2022-10-31 | MUSCN 7.37


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.37 – 31 October, 2022
    TOP STORY

    RNA-Binding Protein LIN28a Regulates New Myocyte Formation in the Heart via lncRNA-H19

    Scientists identified a novel role for RNA-binding protein LIN28a, a master regulator of cellular metabolism, in cardiac repair following injury.
    [Circulation]

    Abstract
    Register for Heart Development and Disease: From Genes to Cures.
    PUBLICATIONSRanked by the impact factor of the journal

    Defective Desmosomal Adhesion Causes Arrhythmogenic Cardiomyopathy by Involving an Integrin-αVβ6/TGF-β Signaling Cascade

    Researchers studied the relevance of defective desmosomal adhesion for arrhythmogenic cardiomyopathy development and progression.
    [Circulation]

    Abstract

    Kynurenine Promotes Neonatal Heart Regeneration by Stimulating Cardiomyocyte Proliferation and Cardiac Angiogenesis

    Investigators found that apical neonatal mouse heart resection surgery led to rapid and consistent increases in cardiac Indoleamine 2,3 dioxygenase-1 expression and kynurenine accumulation.
    [Nature Communications]

    Full Article

    The Developing Epicardium Regulates Cardiac Chamber Morphogenesis by Promoting Cardiomyocyte Growth

    Scientists generated three models of epicardial impairment in zebrafish by mutating the transcription factor genes and ablating tcf21+ epicardial cells and revealed distinct roles of the epicardium during cardiac morphogenesis and signaling pathways underlying epicardial-myocardial crosstalk.
    [Disease Models & Mechanisms]

    Full Article

    Engineered Skeletal Muscle Recapitulates Human Muscle Development, Regeneration and Dystrophy

    The authors described methods for the derivation of skeletal muscle cells and their utility in skeletal muscle tissue engineering with the aim to model skeletal muscle regeneration and dystrophy in vitro.
    [Journal of Cachexia Sarcopenia and Muscle]

    Full Article

    Repurposing Pentamidine Using Hyaluronic Acid-Based Nanocarriers for Skeletal Muscle Treatment in Myotonic Dystrophy

    Researchers proposed hyaluronic acid-based nanoparticles as a novel encapsulation strategy to efficiently deliver pentamidine to skeletal muscle cells. In vitro studies on C2C12 myoblasts and myotubes showed an efficient nanoparticles’ internalization with minimal toxicity.
    [Nanomedicine-Nanotechnology Biology and Medicine]

    AbstractGraphical Abstract

    CXCL12 Is Expressed by Skeletal Muscle Cells in Tongue Oral Squamous Cell Carcinoma

    Scientists clarified the biological and clinical significance of CXCL12 in the tumor microenvironment of oral squamous cell carcinoma by co-culturing human skeletal muscle cells.
    [Cancer Medicine]

    Full Article

    Distinct Patterns of Responses in Endothelial Cells and Smooth Muscle Cells Following Vascular Injury

    Investigators used the droplet-based scRNA-Seq method to characterize the transcriptomes of thousands of individual cells collected from the normal arteries and the arteries with ligation injury, and investigated the early responses of vascular cells and inflammatory cells to the injury.
    [JCI Insight]

    Full ArticleGraphical Abstract

    Dexmedetomidine Alleviates Inflammatory Response and Oxidative Stress Injury of Vascular Smooth Muscle Cell via α2AR/Gsk-3β/Mkp-1/NRF2 Axis in Intracranial Aneurysm

    Researchers investigated the biological functions of dexmedetomidine and its mechanisms against intracranial aneurysm formation and progression using vascular smooth muscle cells.
    [BMC Pharmacology and Toxicology]

    Full Article
    Explore tools and resources for your return to the lab
    REVIEWS

    Insights into Skeletal Stem Cells

    Investigators retrospect to skeletal stem cell (SSC) identification and functional studies. They discuss the principles and approaches to identify bona fide SSCs, highlighting pioneering findings that plot the lineage atlas of SSCs.
    [Bone Research]

    Full Article

    Modeling Cardiac SARS-CoV-2 Infection with Human Pluripotent Stem Cells

    Scientists review studies published since the emergence of the COVID-19 pandemic which utilize human pluripotent stem cells and their cardiovascular derivative cell types to interrogate the tropism and effects of SARS-CoV-2 infection in the heart, as well as explore potential therapies.
    [Current Cardiology Reports]

    Abstract
    INDUSTRY AND POLICY NEWS

    Santhera and ReveraGen Complete NDA Submission to FDA for Vamorolone in Duchenne Muscular Dystrophy

    Santhera Pharmaceuticals and ReveraGen BioPharma, Inc. announced that they have completed the rolling submission of a new drug application to the FDA, seeking priority review for vamorolone for the treatment of Duchenne muscular dystrophy.
    [Santhera Pharmaceuticals Holding AG]

    Press Release

    Dyne Therapeutics Receives FDA Fast Track Designation for DYNE-251 for the Treatment of Duchenne Muscular Dystrophy

    Dyne Therapeutics, Inc. announced that the FDA has granted Fast Track designation for DYNE-251 for the treatment of Duchenne muscular dystrophy mutations amenable to exon 51 skipping.
    [Dyne Therapeutics, Inc.]

    Press Release
    FEATURED EVENT

    Novel Approaches Against Emerging Antimicrobial Resistance

    December 4 – 7, 2022
    Banff, Alberta, Canada

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Lymphatics & Skeletal Muscle Function

    Texas A&M University Health Science Center – Bryan, Texas, United States

    Postdoctoral Fellow – Neural, Cardiac, Endothelial, and Adipose hiPSC Modeling

    Northwestern University – Chicago, Illinois, United States

    Postdoctoral Fellow – Micro-Sampling and Biomarkers

    AstraZeneca – Gothenburg, Sweden

    PhD Scholarship – Vascular Smooth Muscle Cell Aging

    University of East Anglia – Norwich, United Kingdom

    Postdoctoral Researcher – Experimental Muscle

    University of London – Royal Veterinary College – London, United Kingdom

    > See All Jobs

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