Muscle Cell News Volume 7.38 | Nov 07 2022

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    2022-11-07 | MUSCN 7.38


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.38 – 7 November, 2022
    TOP STORY

    A Grip-1–EZH2 Switch Binding to Gata-4 Is Linked to the Genesis of Rhabdomyosarcoma through miR-29a

    Researchers presented that GATA-4 recruited polycomb group proteins such as EZH2 to negatively regulate miR-29a in undifferentiated C2C12 myoblast cells, whereas recruitment of GRIP-1 to GATA-4 proteins displaced EZH2, resulting in the activation of miR-29a during myogenic differentiation.
    [Oncogene]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Doxorubicin Causes Ferroptosis and Cardiotoxicity by Intercalating into Mitochondrial DNA and Disrupting Alas1-Dependent Heme Synthesis

    Investigators found that the accumulation of doxorubicin and iron in mitochondria cooperatively induced ferroptosis in cardiomyocytes and suggested that 5-ALA could be used as a potential therapeutic agent for doxorubicin-induced cardiomyopathy.
    [Science Signaling]

    Abstract

    Polysulfide Protects against Diabetic Cardiomyopathy through Sulfhydration of PPARγ and Sirt-3

    Na2S4, a polysulfide donor, was used to study the therapeutic effects of polysulfide in diabetic cardiomyopathy. result. Results showed that Na2S4 protected cardiomyocytes against high glucose-induced cardiomyocyte injury.
    [Antioxidants & Redox Signaling]

    Abstract

    Gasdermin D Mediates Endoplasmic Reticulum Stress via FAM134B to Regulate Cardiomyocyte Autophagy and Apoptosis in Doxorubicin-Induced Cardiotoxicity

    Investigators found that doxorubicin (DOX) treatment resulted in increased apoptosis and pyroptosis in cardiomyocytes and that caspase-11/GSDMD could mediate DOX-induced cardiotoxicity injury.
    [Cell Death & Disease]

    Full Article

    Astragaloside IV Ameliorates Sepsis-Induced Myocardial Dysfunction by Regulating NOX4/Jnk/Bax Pathway

    Scientists assessed the function of Astragaloside IV in cecal ligation and puncture-induced cardiac dysfunction and explored its underlying mechanisms.
    [Life Sciences]

    Abstract

    Mesenchymal Stromal Cell Spheroids in Sulfated Alginate Enhance Muscle Regeneration

    Investigators used sulfated alginate hydrogels loaded with mesenchymal spheroids to aid in the regeneration of a rat muscle crush injury.
    [Acta Biomaterialia]

    AbstractGraphical Abstract

    Irisin and ALCAT1 Mediated Aerobic Exercise-Alleviated Oxidative Stress and Apoptosis in Skeletal Muscle of Mice with Myocardial Infarction

    Fndc5−/− and Alcat1−/− mice were used to establish a myocardial infarction model. C2C12 cells were treated with H2O2 and recombinant human Irisin or transduced with a lentiviral vector to mediate the overexpression of ALCAT1.
    [Free Radical Biology and Medicine]

    AbstractGraphical Abstract

    Myotubularin-Related Protein14 Prevents Neointima Formation and Vascular Smooth Muscle Cell Proliferation by Inhibiting Polo-Like Kinase1

    Researchers addressed the role of myotubularin‐related protein 14 in neointima formation and vascular smooth muscle cell proliferation after vessel injury.
    [Journal of the American Heart Association]

    Full Article

    Function of Connexin 43 and RhoA/LIMK2/Cofilin Signaling Pathway in Transient Changes of Contraction and Dilation of Human Umbilical Arterial Smooth Muscle Cells

    Scientists explored the role of connexin 43-gap junctions during peri-induction blood pressure fluctuation and elucidated the underlying mechanisms by pretreating human umbilical arterial smooth muscle cells with short-term Angiotensin Ⅱ to simulate transient contraction and dilation of vascular smooth muscle cells.
    [International Journal of Biochemistry & Cell Biology]

    Abstract

    Vaspin Alleviates the lncRNA LEF1-AS1-Induced Osteogenic Differentiation of Vascular Smooth Muscle Cells via the Hippo/Yap Signaling Pathway

    Quantitative real-time polymerase chain reaction and western blotting analysis indicated that LEF1-AS1 overexpression significantly upregulated osteogenic marker Runt-related transcription factor-2 levels and downregulated vascular smooth muscle cell contractile marker α-smooth muscle actin levels.
    [Experimental Cell Research]

    Full Article
    Guide to everything you need to know about cell separation.
    REVIEWS

    Plasticity of Muscle Stem Cells in Homeostasis and Aging

    The authors review recent findings on the role of the niche, or tissue microenvironment, in the modulation of muscle stem cell plasticity and the mechanisms responsible for the drastic loss of stem cell function with aging.
    [Current Opinion in Genetics & Development]

    Full Article

    Advances and Limitations for the Treatment of Spinal Muscular Atrophy

    Investigators provide a comprehensive review of the evolving landscape of spinal muscular atrophy treatment.
    [BMC Pediatrics]

    Full Article
    INDUSTRY AND POLICY NEWS

    Edgewise Therapeutics Announces Initiation of Lynx Phase II Clinical Trial of Edg-5506 for the Treatment of Duchenne Muscular Dystrophy (DMD)

    Edgewise Therapeutics, Inc. announced that it has initiated the LYNX Phase II clinical trial at Rare Disease Research, LLC in Atlanta, Georgia to examine the safety, pharmacokinetics, and effect on biomarkers of muscle damage of EDG-5506 in children with DMD.
    [Edgewise Therapeutics, Inc.]

    Press Release

    Windtree Announces Notice of Allowance from the US Patent and Trademark Office for a New Istaroxime Patent

    Windtree Therapeutics, Inc. reported that the US Patent and Trademark Office has issued a Notice of Allowance of new patent claims for istaroxime administration.
    [Windtree Therapeutics, Inc.]

    Press Release
    FEATURED EVENT

    Inborn Errors of Immunity: From Genetics to Basic Immunological Principles to Therapy

    December 5 – 7, 2022
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    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Vascular Pathophysiology

    Washington University School of Medicine – Saint Louis, Missouri, United States

    Postdoctoral Researcher – iPSC Vascular Smooth Muscle Cells

    University of Galway – Galway, Ireland

    Research Associate – Cell Signaling Research

    University of Nottingham – Nottingham, England, United Kingdom

    Postdoctoral Fellow – Neural, Cardiac, Endothelial, and Adipose hiPSC Modeling

    Northwestern University – Chicago, Illinois, United States

    Postdoctoral Research Associate – Lymphatics & Skeletal Muscle Function

    Texas A&M University Health Science Center – Bryan, Texas, United States

    > See All Jobs

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