Muscle Cell News Volume 7.39 | Nov 14 2022

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    2022-11-14 | MUSCN 7.39


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.39 – 14 November, 2022
    TOP STORY

    Active Tissue Adhesive Activates Mechanosensors and Prevents Muscle Atrophy

    Scientists presented a mechanically active gel-elastomer-nitinol tissue adhesive that generated and delivered muscle-contraction-mimicking stimulation to the targeted tissue with programmed strength and frequency to treat and prevent muscle atrophy.
    [Nature Materials]

    AbstractPress Release
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    PUBLICATIONSRanked by the impact factor of the journal

    Pathogenesis of Cardiomyopathy Caused by Variants in ALPK3, an Essential Pseudokinase in the Cardiomyocyte Nucleus and Sarcomere

    Investigators explored the putative kinase activity of ALPK3 and the consequences of damaging variants using isogenic human induced pluripotent stem cell-derived cardiomyocytes, mice, and human patient tissues.
    [Circulation]

    Abstract

    TRIM35-Mediated Degradation of Nuclear PKM2 Destabilizes GATA4/6 and Induces P53 in Cardiomyocytes to Promote Heart Failure

    Researchers studied the role of pyruvate kinase M2 (PKM2), a glycolytic enzyme, in regulating the transcription factors GATA4/6 and P53. Mice lacking PKM2 in cardiomyocytes had decreased GATA4/6 but increased P53 and developed dilated cardiomyopathy.
    [Science Translational Medicine]

    Abstract

    Dusp6 Deficiency Attenuates Neutrophil-Mediated Cardiac Damage in the Acute Inflammatory Phase of Myocardial Infarction

    Scientists found that dual-specificity phosphatase 6 (Dusp6) deficiency improved cardiac outcomes by predominantly attenuating neutrophil-mediated myocardial damage in acute inflammatory phase after myocardial infarction.
    [Nature Communications]

    Full Article

    MYBPC3 Deficiency in Cardiac Fibroblasts Drives Their Activation and Contributes to Fibrosis

    Investigators revealed an intrinsic role of MYBPC3 in maintaining cardiac fibroblast homeostasis and disruption of MYBPC3 in these cells contributed to the disease pathogenesis of hypertrophic cardiomyopathy.
    [Cell Death & Disease]

    Full Article

    Impaired Mitochondrial Oxidative Metabolism in Skeletal Progenitor Cells Leads to Musculoskeletal Disintegration

    To investigate in vivo roles for mitochondrial oxidative metabolism in musculoskeletal system, scientists developed a mouse model for mitochondrial complex I deficiency by conditionally deleting evolutionarily conserved signaling intermediate in toll pathways in multiple skeletal and muscle cells.
    [Nature Communications]

    Full Article

    A Link between Agrin Signaling and Cav3.2 at the Neuromuscular Junction in Spinal Muscular Atrophy

    Researchers presented that flunarizine promoted acetylcholine receptor clustering in a cell-autonomous, dose- and agrin-dependent manners in C2C12 myotubes.
    [Scientific Reports]

    Full Article

    Wogonin Attenuates Neutrophilic Inflammation and Airway Smooth Muscle Proliferation through Inducing Caspase-Dependent Apoptosis and Inhibiting MAPK/Akt Signaling in Allergic Airways

    Scientists evaluated whether wogonin alleviated airway neutrophilia by inducing neutrophil apoptosis and attenuated airway smooth muscle cell proliferation and migration.
    [Nature Communications]

    Full Article

    An Organ-on-Chip Model of Pulmonary Arterial Hypertension Identifies a BMPR2-SOX17-Prostacyclin Signaling Axis

    Investigators presented a biomimetic model of pulmonary arterial endothelial-smooth muscle cell interactions in pulmonary arterial hypertension, combining natural and induced bone morphogenetic protein receptor 2 dysfunctions with hypoxia to induce smooth muscle activation and proliferation.
    [Communications Biology]

    Full Article

    Alpha-Lipoic Acid Protects against Aortic Aneurysm and Dissection by Improving Vascular Smooth Muscle Cell Function

    Scientists found that Alpha-Lipoic Acid treatment significantly improved aortic aneurysm and dissection and abdominal aortic aneurysm development demonstrated by ameliorated aneurysmal dilation, decreased aortic dissection and aneurysm incidence, improved aortic morphology, and inhibited elastin degradation.
    [Life Sciences]

    Abstract
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    REVIEWS

    Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cardiomyocyte Modelling of Cardiovascular Diseases for Natural Compound Discovery

    The authors provide information on the latest developments in this area of research and help researchers perform screening of natural products using the hiPSC-cardiomyocyte platform.
    [Biomedicine & Pharmacotherapy]

    Full ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    PepGen Announces Positive Preclinical Data for PGN-EDO53, PGN-EDO45 and PGN-EDO44, Three Novel Duchenne Muscular Dystrophy Candidates

    PepGen, Inc. announced non-human primates’ exon skipping data for PGN-EDO53, PepGen’s product candidate in development for the treatment of Duchenne muscular dystrophy patients whose mutations are amenable to an exon 53 skipping approach.
    [PepGen, Inc.]

    Press Release
    FEATURED EVENT

    2022 San Antonio Breast Cancer Symposium

    December 6 – 10, 2022
    San Antonio, Texas, United States

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cardiac Inflammation

    Lund University – Lund, Sweden

    Lecturer – Cell and Developmental Biology

    Imperial College London – London, England, United Kingdom

    Postdoctoral Position – Vascular and Lung Biology

    Yale University – New Haven, Cincinnati, United States

    Postdoctoral Research Associate – Vascular Pathophysiology

    Washington University School of Medicine – Saint Louis, Missouri, United States

    Postdoctoral Researcher – iPSC Vascular Smooth Muscle Cells

    University of Galway – Galway, Ireland

    > See All Jobs

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