 | | Vol. 7.40 – 21 November, 2022 |
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| Scientists showed that the depletion of CD206+ M2-like macrophages (MΦ) promoted skeletal muscle regeneration, as well as that depletion of CD206+ M2-like MΦ during the early phase of repair considerably accelerated the recovery of the injured skeletal muscle through activation of fibroadipogenic progenitors.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified ataxia-telangiectasia mutated (ATM) as a central regulator of the myofibroblastic cancer-associated fibroblast (myoCAFs) phenotype. Differentiating myofibroblasts in vitro and myoCAFs cultured ex vivo displayed activated ATM signaling.
[Cancer Research] |
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| To study m6A function in heart regeneration, investigators modulated Mettl3 expression in vitro and in vivo. Knockdown of Mettl3 significantly increased the proliferation of cardiomyocytes and accelerated heart regeneration following heart injury in neonatal and adult mice.
[eLife] |
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| Comparison of human genome-wide association studies of cardiac disorders with results in flies identified a set of orthologous genes associated with cardiac traits both in Drosophila and in humans. siRNA-mediated gene knockdown was performed in human induced pluripotent stem cells derived cardiomyocytes to show conserved functions in cardiomyocytes from both flies and humans.
[eLife] |
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| Researchers assessed the therapeutic potential of pentraxin 3 inhibition on tyrosine kinase inhibitor-associated cardiotoxicity. They used a human embryonic stem cell line, RUES2, to generate cardiomyocyte cultures for functional testing.
[Biomedicine & Pharmacotherapy] |
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| Investigators studied the functions of dynamin 2 isoforms and their associated phenotypes and, specifically, the ubiquitous and muscle-specific dynamin 2 isoforms expressed in skeletal muscle.
[Nature Communications] |
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| Researchers demonstrated for the first time that Receptor for Activated C-Kinase 1 (RACK1) was an important evolutionary conserved factor in adult satellite cell (SC) differentiation both in vivo and in vitro. RACK1 participated in skeletal muscle homeostasis by activating SC and was required for myogenesis.
[Cell Death Discovery] |
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| The authors identified a potential mechanism for rapid modulation of the smooth muscle cell splicing program in response to external signals during the vascular injury response and atherogenesis.
[Nucleic Acids Research] |
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| Scientists found that galangin, an extract of the ginger plant galangal, restrained the PDGF-BB-induced proliferation, migration and phenotypic switching of vascular smooth muscle cells in a concentration-dependent manner.
[Food & Function] |
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| Investigators optimized gelatin methacrylate/alginate hydrogels for bioprinting three-dimensional smooth muscle cell (SMC) constructs to develop reliable in vitro cellular models to study the phenotypic modulation of SMCs in health and disease.
[Tissue Engineering and Regenerative Medicine] |
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| The authors address the use of 3D culture systems to integrate tissue mechanics to mimic cardiac remodeling.
[Nature Reviews Cardiology] |
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| Investigators discuss the influence of a non-traditional axis involving kidney, bone, and muscle on skeletal muscle plasticity.
[American Journal of Physiology-Cell Physiology] |
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| NTT Research, Inc., announced that its Medical & Health Informatics Lab had entered a three-year joint research agreement with the Harvard John A. Paulson School of Engineering and Applied Sciences.
[NTT Research, Inc.] |
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| December 7 – 9, 2022
Geneva, Switzerland |
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| | Erasmus University Medical Center – Rotterdam, Netherlands |
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| | Cornell University – Ithaca, New York, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| | Lund University – Lund, Sweden |
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| | Imperial College London – London, England, United Kingdom |
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