 | | Vol. 7.42 – 12 December, 2022 |
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| In vitro and in vivo experiments demonstrated that Janus hydrogel could promote the maturation and functions of cardiomyocytes, and facilitate myocardial infarction repair by reducing oxidative damage and inflammatory response, reconstructing electrical conduction and blood supply in infarcted area.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers determined the impact of influenza A virus infection on SARS-CoV-2 pathogenesis and cardiomyocyte function.
[iScience] |
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| To identify novel regulators of skeletal muscle metabolism and function, investigators performed a proteomic analysis of gastrocnemius muscle from 73 genetically distinct inbred mouse strains and used this resource to prioritize targets for a functional genomic screen in human bioengineered skeletal muscles.
[eLife] |
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| Scientists investigated the effects of gliflozins on skeletal muscle cell viability and paracrine function, which were crucial for promoting revascularization in diabetic hindlimb ischemia.
[Acta Pharmacologica Sinica] |
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Findings suggested that Arf GTPase-activating protein (ArfGAP) 3 was expressed in the process of repair after skeletal muscle injury and myoblast differentiation and that ArfGAP3 was positively correlated with protein complex I-related genes.
[Cellular Signalling] |
| | | Investigators showed that extracellular DNA traps were inhibited, and atherosclerotic plaque formation was alleviated in male Myh11CrePad4flox/flox mice undergoing an adeno-associated-virus-8 mediating overexpression of proprotein convertase subtilisin/kexin type 9 mutation injection.
[Nature Communications] |
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| Scientists explored the potential role of ferroptosis, a novel nonapoptotic form of cell death, in smooth muscle cell (SMC) phenotypic switch and related neointimal formation. They found that ferroptotic stress was triggered in cultured dedifferentiated SMCs and arterial neointimal tissue of wire-injured mice.
[Cell Death & Differentiation] |
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| Researchers used genetically modified mouse models enabling the expression of Pannexin1 in vascular cells to be varied. Electrical field stimulation on isolated arteries and blood pressure were assessed.
[Hypertension] |
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| Scientists showed that KLF4 upregulation accompanied vascular smooth muscle cells’ phenotypic switching in atherosclerotic lesions. KLF4 enhanced the metabolic switch to glycolysis by increasing PFKFB3 expression.
[Communications Biology] |
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| The authors focus on the impacts of PM2.5 exposure on vascular smooth muscle cells and further discuss the correlation between exposure to PM2.5 and other vascular diseases, presenting potential protective and treatment strategies to decrease vascular mortality related to air pollution.
[Journal of Applied Toxicology] |
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| Solid Biosciences Inc. announced the closing of its acquisition of AavantiBio, a privately held gene therapy company focused on transforming the lives of patients with Friedreich’s ataxia and rare cardiomyopathies, including its pipeline assets and net cash.
[Solid Biosciences, Inc.] |
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| January 22 – 25, 2023
Santa Fe, New Mexico, United States |
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| | Duke University – Durham, North Carolina, United States |
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| | University of Stirling – Stirling, Scotland, United Kingdom |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | Cornell University – Ithaca, New York, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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