Muscle Cell News Volume 8.00 | Jan 09 2023

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    Jamie Kang
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    2023-01-09 | MUSCN 8.00


    Muscle Cell News by STEMCELL Technologies
    Vol. 8.00 – 9 January, 2023
    TOP STORY

    Genetic Regulation of SMC Gene Expression and Splicing Predict Causal CAD Genes

    Given that vascular smooth muscle cells (SMCs) play critical roles in the development and progression of coronary artery disease (CAD), researchers identified the subset of the CAD genome-wide association studies risk loci associated with the regulation of transcription in distinct SMC phenotypes.
    [Circulation Research]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    MiR-150 Blunts Cardiac Dysfunction in Mice with Cardiomyocyte Loss of β1-Adrenergic Receptor/β-Arrestin Signaling and Controls a Unique Transcriptome

    Scientists presented that miR-150 contributed significantly to β1AR/β-arrestin-mediated cardioprotection by regulating unique ncRNA and gene signatures in cardiomyocytes.
    [Cell Death Discovery]

    Abstract

    Actomyosin-Mediated Cellular Tension Promotes Yap Nuclear Translocation and Myocardial Proliferation through α5 Integrin Signaling

    The authors investigated the role of actomyosin contractility in cardiomyocyte cell cycle arrest, by conditionally-activating ROCK2 kinase domain in the murine postnatal heart. They showed that α5/β1 integrin and fibronectin matrix increased in response to actomyosin-mediated tension.
    [Development]

    Abstract

    A Maladaptive Feedback Mechanism between the Extracellular Matrix and Cytoskeleton Contributes to Hypertrophic Cardiomyopathy Pathophysiology

    Researchers identified a mechanosensing feedback mechanism between the extracellular matrix and cytoskeletal network that regulated mitochondrial function under healthy conditions.
    [Communications Biology]

    Full Article

    Mitochondria Transplant Therapy Improves Regeneration and Restoration of Injured Skeletal Muscle

    Investigators reported the novel finding that systemic mitochondria delivery could enhance muscle regeneration and restore muscle function following BaCl2-induced injury.
    [Journal Of Cachexia Sarcopenia And Muscle]

    Full Article

    Serum Concentration Impacts Myosin Heavy Chain Expression but not Cellular Respiration in Human LHCN-M2 Myoblasts Undergoing Differentiation

    Researchers tested the hypothesis that differentiation with increasing concentrations of serum would enhance myogenesis and mitochondrial function in LHCN-M2 skeletal muscle myoblast cells.
    [Experimental Physiology]

    Full Article

    Continuous Exposure to Isoprenaline Reduced Myotube Size by Delaying Myoblast Differentiation and Fusion through the NFAT-MEF2C Signaling Pathway

    Continuous single-dose isoprenaline (ISO) reduced the nuclear levels of NFATc1/c2 while promoting the accumulation levels of NFATc3/c4 in the nucleus, suggesting that changes in NFATs participated in ISO-mediated alterations in myoblast differentiation/fusion, myotube size, and myofiber specialization.
    [Scientific Reports]

    Full Article

    Osteocalcin Inhibits Myocyte Aging through Promotion of Starvation-Induced Autophagy via IL-6/STAT3 Signaling

    Investigators revealed that compared to control and serum-starved cells, osteocalcin treatment significantly increased the relative expression of LC3-II/LC3-I protein, the numbers of autophagosomes, and levels of intracellular reactive oxygen species.
    [Experimental Gerontology]

    Abstract

    Antagonizing Cholecystokinin a Receptor in the Lung Attenuates Obesity-Induced Airway Hyperresponsiveness

    Scientists reported that cholecystokinin, a metabolic hormone best known for its role in signaling satiation and fat metabolism, was increased in the lungs of obese mice and that pharmacological blockade of cholecystokinin A receptor signaling reduced obesity-associated airway hyperresponsiveness.
    [Nature Communications]

    Full Article
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    REVIEWS

    Transcription Factors: Key Regulatory Targets of Vascular Smooth Muscle Cell in Atherosclerosis

    The authors highlight that, except for environmental factors, vascular smooth muscle cell genes are transcriptionally regulated through complex interactions of multiple conserved cis-regulatory elements and transcription factors.
    [Molecular Medicine]

    Full Article
    INDUSTRY AND POLICY NEWS

    Imbria Enrolls First Patient in the Phase II IMPROVE-DiCE Clinical Trial Evaluating Ninerafaxstat in Patients with Heart Failure with Preserved Ejection Fraction

    Imbria Pharmaceuticals, Inc. announced the enrollment of the first patient in Part 2 of the IMPROVE-DiCE Phase II clinical trial of ninerafaxstat in patients with heart failure with preserved ejection fraction.
    [Imbria Pharmaceuticals, Inc.]

    Press Release
    FEATURED EVENT

    Infections in Pregnancy: Pathogenic Mechanisms, Experimental Advances and Clinical Strategies

    January 22 – 25, 2023
    Santa Fe, New Mexico, United States

    > See All Events

    JOB OPPORTUNITIES

    PhD Fellowship – Pluripotent Stem Cell Biology

    University of Copenhagen – Copenhagen, Denmark

    Postdoctoral Associate – Skeletal Muscle Spatial Transcriptomics

    Cornell University – New York City, New York City, United States

    Postdoctoral Position – Tissue Regeneration Engineering

    Dankook University – Seoul, South Korea

    Faculty Positions – Translational Biomedical Research

    Rutgers Biomedical and Health Sciences – Newark, New Jersey, United States

    Postdoctoral Scientist – Cardiovascular Sciences

    Duke University – Durham, North Carolina, United States

    > See All Jobs

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