 | | Vol. 8.01 – 16 January, 2023 |
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| Investigators identified a non-conducting KCNH2-encoded polypeptide, hERG1NP, that was upregulated in immature cardiomyocytes, and its targeting of the nucleus indirectly modulated hERG1 gating.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists revealed that abraxas 2 (ABRO1) was an imperative contributor to the cell cycle withdrawal and attenuation of proliferative response in the postnatal cardiomyocytes, and could act as a potential target to accelerate cardiomyocyte proliferation and cardiac repair in the adult heart.
[Molecular Therapy] |
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| Researchers identified a surface protein specific for healthy cardiomyocytes, LSMEM2, and validated an anti-LSMEM2 monoclonal antibody for flow cytometry and imaging.
[Nature Cardiovascular Research] |
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| Scientists investigated the role of absent in melanoma 2 (AIM2) and its molecular mechanisms. An ex vivo study was performed on primary cardiomyocytes for different concentrations of glucose.
[Applied Biochemistry And Biotechnology] |
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| The authors overcame prior limitations and enabled monitoring of stem cell behavior and real-time cell fate transitions in culture using a new strategy that permitted spatial segregation and systematic manipulation of biomechanical and biochemical cues in conjunction with single-cell lineage tracing in real-time.
[Regenerative Medicine] |
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| Scientists investigated the role of apical compression by simulating the muscle stem cells’ in vivo mechanical environment by applying physical compression to muscle stem cells’ apical surface.
[Communications Biology] |
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| Researchers extracted apoptotic extracellular vesicles derived from mesenchymal stem cells (MSCs-ApoEVs) to treat cardiotoxin-induced tibialis anterior injury and found that MSCs-ApoEVs promoted muscles regeneration and increased the proportion of multinucleated cells.
[International Journal Of Oral Science] |
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| The authors investigated the cooperative role of glycolysis and fatty acid synthesis in vascular injury-induced vascular smooth muscle cell dedifferentiation and neointima formation.
[Journal Of Pathology] |
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| Investigators studied the effect of Swietenine on the hypoxia-induced phenotypic transformation of pulmonary arterial smooth muscle cells in experimental pulmonary hypertension.
[Canadian Journal Of Cardiology] |
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| The authors provide historical context for the myonuclear domain and evaluate its veracity with respect to mRNA and protein distribution resulting from myonuclear transcription.
[Journal Of Physiology] |
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| Solid Biosciences, Inc. announced its strategic collaboration with Phlox Therapeutics to focus on genetic cardiac diseases. This research collaboration targeted a severe form of genetic dilated cardiomyopathy for which there is currently a significant unmet need for effective treatments.
[Solid Biosciences, Inc.] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | Cornell University – Ithaca, New York, United States |
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| | Pompeu Fabra University – Barcelona, Spain |
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| | Shanghai Clinical Research and Trial Center – Shanghai, China |
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| | Columbia University – New York, New York, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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