 | | Vol. 8.02 – 23 January, 2023 |
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| Scientists investigated whether reactive oxygen species (ROS) produced by the mitochondrial flavoenzyme monoamine oxidase A played a role in cardiomyocyte differentiation from human-induced pluripotent stem cells.
[Basic Research In Cardiology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Functional enrichment analysis pointed to an involvement of extracellular vesicle-related processes in the hearts of β-catΔex3 mice. Human induced pluripotent stem cells-derived cardiomyocytes subjected to pharmacological Wnt activation recapitulated the increased expression of exosomal markers.
[Communications Biology] |
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| In vitro and in vivo assessments were performed using Doxorubicin (DOX)-treated H9C2 cells and rats. It was found that the urotensin II receptor antagonist, Urantide, and exercise training improved DOX-induced cardiac insufficiency and cardiomyocyte apoptosis.
[Scientific Reports] |
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| Researchers used a calorie restriction (CR) model with muscle-specific 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) knockout and overexpression to confirm that CR delayed muscle aging by inhibiting 11β-HSD1. Self-proliferation and differentiation of muscle fibers of muscle stem cells were observed in vitro.
[Frontiers In Medicine] |
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| Investigators tested whether factors released by 3D-engineered human tendon constructs in response to uniaxial tensile loading could stimulate the proliferation and differentiation of human-derived myogenic cells.
[Tissue Engineering Part A] |
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| Researchers described a medium-throughput, unbiased small molecule screen to identify novel disease mechanisms and therapeutic targets using induced pluripotent stem cell (iPSC) technology.
[Stem Cell Reports] |
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| Scientists established that the activation of the bitter taste receptor, TAS2R14, in human airway smooth muscle cells promoted relaxation through F-actin severing.
[American Journal Of Respiratory Cell And Molecular Biology] |
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| Investigators presented a fast, affordable, and reproducible three-cell co-culture system that could represent the different cellular mechanisms of atherosclerosis, extending from atherogenesis to pathological intimal thickening.
[Plos One] |
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| Researchers investigated the potential role of GATA6 as a novel regulator of tracheal fibrosis. It was found that GATA6 and α-smooth muscle actin (α-SMA) were obviously increased in tracheal fibrotic granulations and in TGFβ1-treated primary tracheal fibroblasts.
[Cellular Signalling] |
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| The authors describe the metabolic programs in human pluripotent stem cells (hPSCs) and the metabolic regulation in hPSC-cardiomyocyte production for cardiac regenerative therapy.
[Journal Of Molecular And Cellular Cardiology] |
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| Benitec Biopharma Inc. announced the enrollment of the first oculopharyngeal muscular dystrophy (OPMD) patient into the OPMD natural history phase of the BB-301 clinical development program.
[Benitech Biopharma, Inc.] |
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| February 5 – 8, 2023
Keystone, Colorado, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | BioMed X Institute – New Haven, Connecticut, United States |
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| | Cornell University – Ithaca, New York, United States |
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| | Pompeu Fabra University – Barcelona, Spain |
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| | Shanghai Clinical Research and Trial Center – Shanghai, China |
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