Muscle Cell News Volume 8.03 | Jan 30 2023

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    Jamie Kang
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    2023-01-30 | MUSCN 8.03


    Muscle Cell News by STEMCELL Technologies
    Vol. 8.03 – 30 January, 2023
    TOP STORY

    Lineage-Specific Regulatory Changes in Hypertrophic Cardiomyopathy Unraveled by Single-Nucleus RNA-Seq and Spatial Transcriptomics

    Researchers performed single-nucleus RNA-seq of the cardiac tissues from hypertrophic cardiomyopathy patients or healthy donors and conducted spatial transcriptomic assays on tissue sections from patients.
    [Cell Discovery]

    Full Article
    Derive and expand human skeletal muscle progenitors in a serum-free setting using MyoCult™-SF Expansion Supplement Kit (Human).
    PUBLICATIONSRanked by the impact factor of the journal

    Binary Colloidal Crystals Promote Cardiac Differentiation of Human Pluripotent Stem Cells via Nuclear Accumulation of SETDB1

    Cell nucleus, cytoskeleton, and epigenetic states of human-induced pluripotent stem cells on the 5PM binary colloidal crystals were analyzed using atomic force microscopy, molecular biology assays, and the assay for transposase-accessible chromatin sequencing.
    [ACS Nano]

    Full ArticleGraphical Abstract

    The H2A.Z and NuRD Associated Protein HMG20A Controls Early Head and Heart Developmental Transcription Programs

    Scientists implicated HMG20A as part of the H2A.Z/PWWP2A/NuRD-axis and revealed it as a key modulator of intricate developmental transcription programs that guide the differentiation of neural crest cells and cardiomyocytes.
    [Nature Communications]

    Full Article

    RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis

    Investigators evaluated the inhibitory effect of RING finger protein 10 on pirarubicin-mediated chemotherapy-related cardiotoxicity and its molecular mechanism.
    [Nature Communications]

    Full Article

    MSCs-Derived Apoptotic Extracellular Vesicles Promote Muscle Regeneration by Inducing Pannexin 1 Channel-Dependent Creatine Release by Myoblasts

    Scientists extracted apoptotic extracellular vesicles derived from mesenchymal stem cells (MSCs-ApoEVs) to treat cardiotoxin-induced tibialis anterior injury and found that MSCs-ApoEVs promoted muscles regeneration and increased the proportion of multinucleated cells.
    [International Journal of Oral Science]

    Full Article

    MME+ Fibro-Adipogenic Progenitors Are the Dominant Adipogenic Population during Fatty Infiltration in Human Skeletal Muscle

    Researchers identified an MME+ fibro-adipogenic progenitor subpopulation in skeletal muscles which, based on ex vivo characterization as well as transplantation experiments, exhibited high adipogenic potential.
    [Communications Biology]

    Full Article

    Lipin1 Plays Complementary Roles in Myofiber Stability and Regeneration in Dystrophic Muscles

    Using a cell culture system, the authors found that lipin1 deficiency led to elevated expression levels of necroptotic markers and medium creatine kinase which could be due to sarcolemmal damage. Most importantly, restoration of lipin1 inhibited the elevation of necroptotic markers in differentiated primary lipin1-deficient myoblasts.
    [Journal Of Physiology]

    Abstract

    VGLL4-TEAD1 Promotes Vascular Smooth Muscle Cell Differentiation from Human Pluripotent Stem Cells via TET2

    Using microarray profiling, investigators found that the Hippo pathway components vestigial-like family member 4 (VGLL4) and TEA domain transcription factor 1 (TEAD1) were upregulated during vascular smooth muscle cell differentiation from H1 ESCs.
    [Journal of Molecular and Cellular Cardiology]

    Full ArticleGraphical Abstract

    Deficiency of Filamin A in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension in Mice

    Researchers explored the role of Filamin A (FLNA) in vascular smooth muscle cells during the development of pulmonary arterial hypertension (PAH). Smooth muscle cell‑specific FLNA‑deficient mice were generated and the mice were then exposed to hypoxia for 28 days to build the mouse model of PAH.
    [International Journal of Molecular Medicine]

    Abstract
    Explore the Science Events Calendar to discover conferences, podcasts, webinars, and more!
    REVIEWS

    Psychological and Biological Mechanisms Linking Trauma with Cardiovascular Disease Risk

    Investigators summarize the evidence for key psychological and biological mechanisms linking experiences of trauma with cardiovascular disease risk. Additionally, they describe various methodologies for measuring these mechanisms in an effort to inform future research related to potential pathways.
    [Translational Psychiatry]

    Full Article

    Emerging Role of Mitophagy in Heart Failure: From Molecular Mechanism to Targeted Therapy

    The authors discuss the molecular underpinnings of mitophagy and the roles of different mitophagy adaptors. Then, the multiple and complex influences of mitophagy on heart failure are summarized.
    [Cell Cycle]

    Abstract
    INDUSTRY AND POLICY NEWS

    Muscular Dystrophy Association’s Venture Philanthropy Program Announces Investment in Non-Viral Gene Therapy

    The Muscular Dystrophy Association announced a $650,000 investment in Myosana Therapeutics via its MDA Venture Philanthropy program.
    [Muscular Dystrophy Association]

    Press Release
    FEATURED EVENT

    Skin-Immune Crosstalk

    February 13 – 16, 2023
    Breckenridge, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Engineering and Bioprinting of Diaphragm Muscle Tissue

    University of Bayreuth – Bayreuth, Germany

    Postdoctoral Researcher – Complex Human Ex Vivo Models of Tissue Inflammation

    BioMed X Institute – New Haven, Connecticut, United States

    Postdoctoral Position – Skeletal Muscle Spatial Transcriptomics

    Cornell University – Ithaca, New York, United States

    Group Leader – Cell Biology

    Pompeu Fabra University – Barcelona, Spain

    Physician-Scientist Positions – Clinical and Basic Research

    Shanghai Clinical Research and Trial Center – Shanghai, China

    > See All Jobs

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