 | | Vol. 8.04 – 6 February, 2023 |
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| Researchers demonstrated that the Pax3-expressing melanocytes are a skin cell type for skeletal muscle cell fate conversion in chemical reprogramming.
[Journal Of Cachexia Sarcopenia And Muscle] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Cardiac tissue from the tissue-specific or systemic model showed increased apoptosis and cardiac myocytes from muscle-specific creatinine kinase (Ckmm)-Cre+/-;Ercc1−/fl mice were hypersensitive to genotoxins, resulting in apoptosis.
[Aging Cell] |
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| Scientists disrupted mouse suprachiasmatic nucleus (SCN) functions to investigate the role of SCN in cardiac dysfunction post-myocardial infarction (MI). They showed that SCN ablation significantly alleviated MI-induced cardiac dysfunction and fibrosis, and promoted angiogenesis.
[Acta Pharmacologica Sinica] |
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| In vitro, H9C2 cells were transfected with NSUN2 siRNA or overexpressed lentivirus and then treated with 500 ng/ml doxorubicin. After 24 h, the changes in reactive oxygen species, apoptosis, and NSUN2 expression were detected.
[Cell Death Discovery] |
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| Investigators assessed the role that different host animal models and anatomic implant locations played in vascularization and cardiomyocyte survival within engineered tissues.
[Scientific Reports] |
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| To quantitatively understand how hierarchical chromatin architecture changes during muscle stem cell aging, researchers generated 3D chromatin conformation maps and integrated these datasets with multi-omic profiles from bulk populations and single cells.
[Aging Cell] |
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| Scientists identified Hedgehog/platelet-derived growth factor targets in several postnatal lung mesenchymal cell populations, including myofibroblasts, by single-cell transcriptomic analysis.
[American Journal Of Respiratory Cell And Molecular Biology] |
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| The thoracic aortas were perivascularly administrated with calcium chloride, and human aortic smooth muscle cells were incubated with angiotensin II to simulate the thoracic aortic aneurysm model in vivo and in vitro, respectively.
[International Immunopharmacology] |
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| Researchers found that Krüppel-Associated Box-Associated Protein 1 (KAP1) participated in the osteoblast differentiation of vascular smooth muscle cells via the extracellular regulated protein kinase RUNX family transcription factor 2 cascade.
[Molecular Biology Reports] |
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| The authors review the underlying mechanisms of the skeletal muscle clock that drive muscle physiology, with a particular focus on metabolic health.
[Nature Reviews Endocrinology] |
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| The University of Texas Southwestern physician-scientist Hesham Sadek, M.D., Ph.D., received the prestigious NIH Outstanding Investigator Award to support his ongoing research into mechanisms behind heart regeneration that could lead to treatments for heart failure.
[University of Texas Southwestern] |
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| February 22 – 23, 2023
Boston, Massachusetts, United States |
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| | The Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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| | University of Bayreuth – Bayreuth, Germany |
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| | BioMed X Institute – New Haven, Connecticut, United States |
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| | Cornell University – Ithaca, New York, United States |
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| | Pompeu Fabra University – Barcelona, Spain |
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