 | | Vol. 8.05 – 13 February, 2023 |
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| Using muscle stem cells as a model, investigators showed that aging led to a significant transcriptomic shift in their subpopulations, accompanied by locus-specific gain and loss of chromatin accessibility and DNA methylation.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported that the pore-forming α1C subunit of Ca(v)1.2 was palmitoylated in cardiac tissue and that this modification controlled the voltage sensitivity of Ca(v)1.2 in voltage-clamped engineered cell lines.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors showed that lysine demethylase 8 (Kdm8) maintained an active mitochondrial gene network by repressing Tbx15, thus preventing dilated cardiomyopathy leading to lethal heart failure.
[Nature Cardiovascular Research] |
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| Scientists developed a series of automated data processing algorithms to assess changes in action potential properties for cardiotoxicity testing in 3D-engineered cardiac microtissues generated from hiPSC-derived cardiomyocytes.
[PLOS One] |
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| Researchers demonstrated that the Pax3-expressing melanocytes to be a skin cell type for skeletal muscle cell fate conversion in chemical reprogramming.
[Journal Of Cachexia Sarcopenia And Muscle] |
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| Investigators constructed an in vitro cell-based platform to model skeletal muscles with specific biomolecules released from the skeletal muscle cells, using conditioned media from the normal versus injured culture conditions.
[Biophysical Journal] |
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| Scientists aimed to explore several bioengineering approaches to promote maturity of model which uses microgravity-accelerated musculoskeletal aging of muscle constructs, consisting of human skeletal muscle cells grown in 3D within a hydrogel.
[Biophysical Journal] |
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| The functional and molecular link between loss of bone morphogenetic protein receptor 2 (BMPR2) in pulmonary artery smooth muscle cells and pulmonary arterial hypertension pathogenesis was investigated, as most previous studies focused on BMPR2 in pulmonary artery endothelial cells.
[Circulation Research] |
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| Scientists found that G9a was increased in pulmonary arterial smooth muscle cells from pulmonary arterial hypertension patients, as well as in remodeled pulmonary arteries from animal models.
[American Journal Of Respiratory Cell And Molecular Biology] |
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| The authors delve into the different sources of stem cells used in the generation of myogenic tissues, the role of soluble growth factors, use of scaffolding techniques, biomolecular cues, relevance of mechanical stimulation, and key transcription factors involved, aimed at inducing myogenic differentiation.
[Tissue Engineering Part B-Reviews] |
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| Rocket Pharmaceuticals, Inc. announced that the FDA has granted RMAT designation to RP-A501, the Company’s investigational adeno-associated virus-based gene therapy for the treatment of Danon Disease, a devastating and fatal genetic cardiac disease for which there are no disease-altering therapies available.
[Rocket Pharmaceuticals, Inc.] |
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| March 6 – 8, 2023
Paris, France |
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| | The University of Melbourne – Melbourne, Australia |
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| | The Max Delbrück Center for Molecular Medicine – Berlin, Germany |
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| | Swiss Federal Institute of Technology in Lausanne – Lausanne, Switzerland |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Cornell University – Ithaca, New York, United States |
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