Muscle Cell News Volume 8.06 | Feb 27 2023

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    2023-02-27 | MUSCN 8.06


    Muscle Cell News by STEMCELL Technologies
    Vol. 8.06 – 27 February, 2023
    TOP STORY

    The Gut Microbiota Promotes Distal Tissue Regeneration via RORγ+ Regulatory T Cell Emissaries

    Scientists discovered highly analogous populations of microbiota-dependent Treg cells that promoted tissue regeneration at extra-gut sites, notably acutely injured skeletal muscle and fatty liver.
    [Immunity]

    AbstractGraphical Abstract
    Derive and expand human skeletal muscle progenitors in a serum-free setting using MyoCult™-SF Expansion Supplement Kit (Human).
    PUBLICATIONSRanked by the impact factor of the journal

    Alpha Kinase 3 Signaling at the M-Band Maintains Sarcomere Integrity and Proteostasis in Striated Muscle

    ALPK3 deficiency impaired contractility both in human cardiac organoids and in the hearts of mice harboring a pathogenic truncating Alpk3 variant.
    [Nature Cardiovascular Research]

    Full Article

    Platelet-Instructed SPP1+ Macrophages Drive Myofibroblast Activation in Fibrosis in a CXCL4-Dependent Manner

    Investigators discovered a population of profibrotic macrophages marked by expression of Spp1, Fn1, and Arg1 —termed Spp1 macrophages — which expanded after organ injury.
    [Cell Reports]

    Full ArticleGraphical Abstract

    E3 Ligase Deltex2 Accelerates Myoblast Proliferation and Inhibits Myoblast Differentiation by Targeting Pax7 and MyoD, Respectively

    Scientists reported that Deltex2, which was highly expressed in muscles, positively regulated myoblast proliferation via mediating the expression of Pax7.
    [Acta Biochimica et Biophysica Sinica]

    Full ArticleGraphical Abstract

    Multiscale 3D Genome Reorganization during Skeletal Muscle Stem Cell Lineage Progression and Aging

    Researchers comprehensively mapped the 3D genome topology reorganization during mouse skeletal muscle stem cells lineage progression.
    [Science Advances]

    Full Article

    DUX4 Double Whammy: The Transcription Factor That Causes a Rare Muscular Dystrophy Also Kills the Precursors of the Human Nose

    The authors showed that upon SMCHD1 ablation, double homeobox 4 (DUX4) became derepressed in H9 hESCs as they differentiated toward a placode cell fate, triggering cell death.
    [Science Advances]

    Full ArticlePress Release

    Dysfunctional Mitochondria Accumulate in a Skeletal Muscle Knockout Model of Smn1, the Causal Gene of Spinal Muscular Atrophy

    Investigators showed that survival motor neuron (SMN) loss in mouse skeletal muscle led to the accumulation of dysfunctional mitochondria.
    [Cell Death & Disease]

    Full Article

    Single-Cell Analysis Reveals Distinct Immune and Smooth Muscle Cell Populations That Contribute to Chronic Thromboembolic Pulmonary Hypertension

    Using in vitro assays, scientists analyzed phenotypic differences between chronic thromboembolic pulmonary hypertension thrombus and healthy pulmonary vascular cells studying potential therapeutic targets.
    [American Journal Of Respiratory And Critical Care Medicine]

    Abstract

    The Effect of Nano-Liposomal Sodium Nitrite on Smooth Muscle Cell Growth in a Tissue-Engineered Small-Diameter Vascular Graft

    The liposomal drug-loaded small-diameter vascular graft could prevent the overgrowth of smooth muscle cells and the formation of intimal hyperplasia in the graft.
    [Artificial Organs]

    Abstract
    Resources for Your T Cell Therapy Research
    REVIEWS

    Cellular Interplay in Skeletal Muscle Regeneration and Wasting: Insights From Animal Models

    Animal models, mostly rodents, can help to decipher the mechanisms behind this highly dynamic process, by allowing access to every muscle as well as time-course studies.
    [Journal Of Cachexia Sarcopenia And Muscle]

    Full Article
    INDUSTRY AND POLICY NEWS

    National Institutes of Health Grant Funds Interdisciplinary Stem Cell Research

    A team of Purdue University scientists led by Dr. Shihuan Kuang had received a $2.5 million grant from the National Institutes of Health to define the role of lipid droplets in muscle stem cell function, a study with implications in both humans and livestock.
    [Purdue University]

    Press Release
    FEATURED EVENT

    Oxford Vascular Biology Symposium 2023

    March 27, 2023
    Oxford, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Mitochondrial Dynamics

    Washington University School of Medicine – St. Louis, Missouri, United States

    Faculty Position – Inflammation in Health and Disease

    University of Minnesota – Minneapolis, Minnesota, United States

    Postdoctoral Research Fellow – Cardiac Physiology

    University of Michigan – Ann Arbor, Michigan, United States

    Postdoctoral Fellow – Cardiovascular Metabolism

    The University of British Columbia – Vancouver, British Columbia, Canada

    PhD Position – Spatial Transcriptomics in Metabolic & Cardiovascular Disease

    University of Gothenburg – Gothenburg, Sweden

    > See All Jobs

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