Muscle Cell News Volume 8.07 | March 6 2023

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    Laurisa Dohm
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    2023-03-16 | MUSCN 8.07


    Muscle Cell News by STEMCELL Technologies
    Vol. 8.07 – 6 March, 2023
    TOP STORY

    MYTHO Is a Novel Regulator of Skeletal Muscle Autophagy and Integrity

    The authors identified and characterized a novel FoxO-dependent gene, d230025d16rik which they named Mytho (Macroautophagy and YouTH Optimizer), as a regulator of autophagy and skeletal muscle integrity in vivo.
    [Nature Communications]

    Full Article
    Guide to everything you need to know about cell separation.
    PUBLICATIONSRanked by the impact factor of the journal

    Fibroblast Growth Factor 18 Alleviates Stress-Induced Pathological Cardiac Hypertrophy in Male Mice

    FGF18 heterozygous and inducible cardiomyocyte-specific FGF18 knockout male mice exposed to transverse aortic constriction demonstrated exacerbated pathological cardiac hypertrophy with increased oxidative stress, cardiomyocyte death, fibrosis, and dysfunction.
    [Nature Communications]

    Full Article

    PITX2 Induction Leads to Impaired Cardiomyocyte Function in Arrhythmogenic Cardiomyopathy

    The authors identified a novel missense mutation within desmoplakin in a patient clinically diagnosed with arrhythmogenic cardiomyopathy. Using CRISPR-Cas9, they corrected this mutation in patient-derived human induced pluripotent stem cells.
    [Stem Cell Reports]

    Full ArticlePress ReleaseGraphical Abstract

    Single-Cell RNA Sequencing Reveals Maturation Trajectory in Human Pluripotent Stem Cell-Derived Cardiomyocytes in Engineered Tissues

    Researchers studied the cellular phenotype of human pluripotent stem cell-derived cardiomyocytes by comparing their single-cell gene expression and functional profiles in three engineered cardiac tissue configurations.
    [iScience]

    AbstractGraphical Abstract

    Single-Cell Transcriptome Dynamics of the Autotaxin-Lysophosphatidic Acid Axis during Muscle Regeneration Reveal Proliferative Effects in Mesenchymal Fibro-Adipogenic Progenitors

    Scientists used public bulk and single-cell RNA sequencing datasets to explore the expression of Lpar1–6, Enpp2, and Plpp genes under skeletal muscle homeostasis and regeneration conditions.
    [Frontiers In Cell And Developmental Biology]

    Full Article

    Cannabidiol Improves Muscular Lipid Profile by Affecting the Expression of Fatty Acid Transporters and Inhibiting De Novo Lipogenesis

    Gas–liquid chromatography and Western blotting were applied in order to determine the intramuscular lipid content and total expression of selected proteins in the white and red gastrocnemius muscle, respectively.
    [Scientific Reports]

    Full Article

    Skeletal Muscle Mitochondrial Interactome Remodeling Is Linked to Functional Decline in Aged Female Mice

    By making use of quantitative chemical cross-linking technologies, scientists showed that changes in the muscle mitochondrial interactome contributed to mitochondrial functional decline in aging in female mice.
    [Nature Aging]

    Abstract

    BACH1 Deficiency Prevents Neointima Formation and Maintains the Differentiated Phenotype of Vascular Smooth Muscle Cells by Regulating Chromatin Accessibility

    Exploring the role of the transcription factor BTB and CNC homology 1 (BACH1) in vascular remodeling, investigators found that BACH1 was highly expressed in human atherosclerotic plaques and had high transcriptional factor activity in vascular smooth muscle cells of human atherosclerotic arteries.
    [Nucleic Acids Research]

    Full Article

    Plasticity in Airway Smooth Muscle Differentiation during Mouse Lung Development

    Single cell RNA-seq identified an serum response factor-null smooth muscle cluster, wrapping the airways of mutant lungs, which lacked contractile smooth muscle markers but retained many features of control smooth muscle.
    [Developmental Cell]

    AbstractGraphical Abstract
    REVIEWS

    Bioreactors for Engineering Patient-Specific Tissue Grafts

    Investigators discuss patient-specific bioreactors that can be used to engineer skin, small-diameter arteries, and musculoskeletal tissues.
    [Nature Reviews Bioengineering]

    Abstract
    INDUSTRY AND POLICY NEWS

    AskBio Receives European Commission Orphan Drug Designation through its EU-Based subsidiary BrainVectis for AB-1003, a Novel Investigational AAV Gene Therapy for the Treatment of Limb-Girdle Muscular Dystrophy (LGMD)

    AB-1003 is a novel investigational recombinant adeno-associated virus based gene therapy currently being developed as a one-time intravenous infusion for the treatment of patients with LGMD type 2I/R9.
    [Asklepios BioPharmaceutical, Inc.]

    Press Release
    FEATURED EVENT

    Lund Stem Cell Center 20th Anniversary

    April 17 – 19, 2023
    Lund, Sweden

    > See All Events

    JOB OPPORTUNITIES

    PhD Position – Muscle Physiology

    Hannover Medical School – Hanover, Germany

    PhD Position – Metabolic and Cardiovascular Disease

    University of Gothenburg – Gothenburg, Sweden

    Faculty Position – Inflammation in Health and Disease

    University of Minnesota – Minneapolis, Minnesota, United States

    Postdoctoral Research Associate – Mitochondrial Dynamics

    Washington University School of Medicine – St. Louis, Missouri, United States

    Postdoctoral Fellow – Cardiovascular Metabolism

    The University of British Columbia – Vancouver, British Columbia, Canada

    > See All Jobs

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