Muscle Cell News Volume 8.08 | Mar 13 2023

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    2023-03-13 | MUSCN 8.08


    Muscle Cell News by STEMCELL Technologies
    Vol. 8.08 – 13 March, 2023
    TOP STORY

    Return of the Tbx5; Lineage-Tracing Reveals Ventricular Cardiomyocyte-Like Precursors in the Injured Adult Mammalian Heart

    Researchers identified a Tbx5-expressing ventricular cardiomyocyte-like precursor population, in the injured adult mammalian heart.
    [NPJ Regenerative Medicine]

    Full Article
    PUBLICATIONSRanked by the impact factor of the journal

    Malat1 Deficiency Prevents Neonatal Heart Regeneration by Inducing Cardiomyocyte Binucleation

    Using in vivo and in vitro approaches, investigators identified the lncRNA Malat1 as a key player in postnatal cardiac regeneration.
    [JCI Insight]

    Full ArticleGraphical Abstract

    Novel Method of Differentiating Human Induced Pluripotent Stem Cells To Mature Cardiomyocytes via Sfrp2

    Scientists investigated if Secreted Frizzled Related Protein 2 (Sfrp2) would drive differentiation of human induced pluripotent stem cells into cardiomyocytes, and found that Sfrp2 induced robust cardiac differentiation.
    [Scientific Reports]

    Full Article

    Perfusable Biohybrid Designs for Bioprinted Skeletal Muscle Tissue

    Stable biohybrid designs of centimeter-scale skeletal muscle tissue were realized via extrusion-based bioprinting of an optimized polymeric blend based on gelatin methacryloyl and sodium alginate.
    [Advanced Healthcare Materials]

    Abstract

    Nuclear m6A Reader YTHDC1 Promotes Muscle Stem Cell Activation/Proliferation by Regulating mRNA Splicing and Nuclear Export

    The authors investigated the previously uncharacterized regulatory roles of YTHDC1, a N(6)-methyladenosine (m6A) reader in mouse satellite cells.
    [eLife]

    Abstract

    microRNA-501 Controls Myogenin+/CD74+ Myogenic Progenitor Cells during Muscle Regeneration

    Researchers investigated mechanisms of age-related changes in myogenic progenitor cells using the tissue-specific microRNA 501.
    [Molecular Metabolism]

    Full Article

    Activation of β-Catenin in Mesenchymal Progenitors Leads to Muscle Mass Loss

    Scientists found the canonical Wnt pathway to be activated in mesenchymal progenitors from cancer-induced cachectic mouse muscle and then induced β-catenin transcriptional activity in murine mesenchymal progenitors.
    [Developmental Cell]

    AbstractGraphical Abstract

    Contractility-Induced Self-Organization of Smooth Muscle Cells: From Multilayer Cell Sheets to Dynamic Three-Dimensional Clusters

    Investigators combined in vitro experiments and physical modeling to show that three-dimensional clusters initiated when cellular contractile forces induced a hole in a flat smooth muscle cell sheet.
    [Communications Biology]

    Full Article
    How to prioritize and manage your research projects
    REVIEWS

    Repurposing Biomedical Muscle Tissue Engineering for Cellular Agriculture: Challenges and Opportunities

    The authors critically compare muscle tissue engineering for biomedical versus food applications, and discuss the limitations of biomedical tissue engineering practices in achieving the important requirements of food production.
    [Trends In Biotechnology]

    Abstract

    Regulated Cell Death Pathways in Cardiomyopathy

    Scientists summarize the latest progress from studies on regulated cell death pathways in cardiomyocytes in the context of the pathogenesis of cardiomyopathies, with particular emphasis on apoptosis, necroptosis, ferroptosis, autophagy, and pyroptosis.
    [Acta Pharmacologica Sinica]

    Abstract
    INDUSTRY AND POLICY NEWS

    Muscular Dystrophy Association Announces Nearly $400K in Research Grants To Address Challenges in Duchenne Muscular Dystrophy Gene Therapy

    Muscular Dystrophy Association announced two research grants designed to address potential transgene-triggered safety concerns in Duchenne muscular dystrophy gene therapies.
    [Muscular Dystrophy Association]

    Press Release
    FEATURED EVENT

    Vascular Inflammation and the ECM

    April 20 – 21, 2023
    Sheffield, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Duchenne Muscular Dystrophy

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    PhD Position – Muscle Physiology

    Hannover Medical School – Hanover, Germany

    Postdoc Positions – Cardiovascular Biology, Stem Cell Biology, Immunology, or Tissue Engineering

    Yale School of Medicine – New Haven, Connecticut, United States

    Faculty Position – Inflammation in Health and Disease

    University of Minnesota – Minneapolis, Minnesota, United States

    Research Assistant – Nutrition in Growth and Function of Skeletal Muscle

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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