 | | Vol. 8.09 – 20 March, 2023 |
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| Human variants in filamin C are linked to a variety of cardiomyopathies, and in this study, scientists investigated an in-frame deletion in a patient with restrictive cardiomyopathy.
[Cell Reports Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| MiR-192-5p– and miR-432-5p–depleted cardiac c-kit+ cell-V small extracellular vesicles enhanced cardiac function by reducing fibrosis and necrotic inflammatory responses.
[Science Advances] |
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| To elucidate whether the coxsackievirus and adenovirus receptor (CAR) contributed to hypoxia signaling and myocardial infarction pathology, researchers used a gain- and loss-of-function approach in transfected HEK293 cells, H9c2 cardiomyocytes and CAR knockout mice.
[Experimental And Molecular Medicine] |
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| The authors investigated whether fibrotic extracellular matrix scarring affected human skeletal muscle progenitor cell functions that are essential for myoregeneration.
[NPJ Regenerative Medicine] |
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| Investigators profiled 24,161 nuclei in semitendinosus muscle-tendon samples from three healthy males by single nucleus RNA-sequencing, alongside spatial transcriptomics, to gain insight into the genes characterizing this specialization in humans.
[Journal Of Cell Science] |
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| Scientists assessed transcriptome-wide responses in skeletal muscle and circulating extracellular vehicles to a single exercise bout in young adults randomized to conventional resistance training or high-intensity training.
[Physiological Genomics] |
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| Investigators identified the mouse intestinal stem cell niche as a complex, multi-layered structure that encompassed distinct mesenchymal and smooth muscle populations.
[Developmental Cell] |
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| In vitro, hypoxia-induced hyperproliferation and activated glycolytic processes in mouse pulmonary arterial smooth muscle cells were impaired by JMJD1C knockdown.
[Cell Death Discovery] |
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| Pulmonary arterial smooth muscle cells (PASMC) were isolated from rats and treated with PDGF-BB to simulate PASMC proliferation, and shRNA for EIF3 was conducted to investigate the mechanism behind the role of EIF3A in PASMC function in vitro.
[Experimental Cell Research] |
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| The authors present obesity as an evolutionarily novel condition, summarize the epidemiological evidence on its detrimental cardiometabolic consequences, and discuss the major mechanisms involved in the association between obesity and the risk of cardiometabolic diseases.
[Nature Reviews Cardiology] |
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| Scientists summarize emerging concepts about metabolic landscapes of cardiac aging, with specific focuses on why metabolic profile alters during cardiac degeneration and how we could utilize the current knowledge to improve the management of cardiac aging.
[Signal Transduction And Targeted Therapy] |
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| Two weeks after saying the FDA would assess its gene therapy without an advisory committee meeting, Sarepta has revealed the agency will now convene experts to dig into the data on its Duchenne muscular dystrophy submission.
[Fierce Biotech] |
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| March 31, 2023
Amsterdam, The Netherlands |
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| | Columbia University – New York, New York, United States |
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| | University of Southern California – Los Angeles, California, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | Yale School of Medicine – New Haven, Connecticut, United States |
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| | Hannover Medical School – Hanover, Germany |
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